Peter J. Quesenberry - Böcker

Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomesin the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medicaldisciplines, as well as their role in cell-cell communication. It is intended to serve as a referencesource for clinicians, physicians, and research scientists who wish to gain insight into the mostrecent advances in this rapidly growing field.

The exosome revolution may well be the greatest advance in physiology and medicine sinceantibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is amajor breakthrough in our understanding of how cells function.

Provides readers with a broad and timely overview of exosomes in health and disease, closingwith a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. Summarizes the most recent laboratory and clinical findings on exosomes across numerousmedical disciplines, thereby offering readers a broad-ranging and solid foundation for prospectiveinvestigative efforts Twenty-one chapters authored by a global team of peer-acknowledged experts, each representinga key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing

STEM CELL BIOLOGY AND GENE THERAPY Edited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, and Sherman Weissman Advances in molecular genetics and recombinant DNA technology have ushered in a new era in medical therapeutic research. New insights into the molecular basis of human disease and the role played by biological regulatory mechanisms have precipitated tremendous drug development efforts backed by intensive research into human gene therapy worldwide. Stem Cell Biology and Gene Therapy is the first book to thoroughly cover major advances in the field and their applications to novel molecular therapies. This self-contained volume integrates biological and clinical components of stem cell biology, examines some of the most difficult aspects of gene therapy, and provides a systematic review of advanced gene modification techniques. Twenty essays by leading researchers address some of the most compelling topics in contemporary medical research, including:* Fundamental regulatory mechanisms that operate in stem cells* Stem cells from a therapeutic perspective, including preparations of stem cells and their therapeutic potential as vehicles for gene therapy* Delivery systems for therapeutic genes, including an overview of the most promising vectors* Clinical applications for gene therapy, covering a broad range of diseases such as hemophilia, cancers, neurological disease, and more Complete with illustrations and real-world examples of a variety of disorders, Stem Cell Biology and Gene Therapy is essential for researchers in gene therapy and members of the biotechnology industry who are developing human molecular therapies for commercial use. It is also an important reference for molecular biologists, cell biologists, immunologists, molecular geneticists, hematologists, cancer researchers, biochemists, and anyone working in internal medicine.

This book will be the first that focuses on solely on model organisms for lymphoma. It's editors are internationally recognized in the field.