Denis Noble - Böcker

Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomesin the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medicaldisciplines, as well as their role in cell-cell communication. It is intended to serve as a referencesource for clinicians, physicians, and research scientists who wish to gain insight into the mostrecent advances in this rapidly growing field.

The exosome revolution may well be the greatest advance in physiology and medicine sinceantibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is amajor breakthrough in our understanding of how cells function.

Provides readers with a broad and timely overview of exosomes in health and disease, closingwith a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. Summarizes the most recent laboratory and clinical findings on exosomes across numerousmedical disciplines, thereby offering readers a broad-ranging and solid foundation for prospectiveinvestigative efforts Twenty-one chapters authored by a global team of peer-acknowledged experts, each representinga key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing

What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out thesystems biology view of life.

What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes.But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism.The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life.

This book is based on papers presented at a Symposium held in Seoul, Korea in 1992. The idea for the symposium developed naturally from work by the editors and their colleagues on the possible role of certain amino acids, like taurine, that are strongly concentrated by the cells of the heart, and the relationship between such acids and membrane ionic currents. The first obvious question was whether it is possible to identify the transport mechanisms involved for taurine and whether they are electrogenic. The second question is what function could be served by such processes: does taurine play an essential role in cardiac tissue and is this important in protecting the heart from disease? A number of the world's leading cardiac electrophysiologists and taurine specialists attended the symposium to discuss these questions. The papers in this volume range all the way from fundamental research on ionic current mechanisms in the heart to the use of taurine in clinical practice.

Life is definitively purposive and creative. Organisms use genes in controlling their destiny. This book presents a paradigm shift in understanding living systems. The genome is not a code, blueprint or set of instructions. It is a tool orchestrated by the system. This book shows that gene-centrism misrepresents what genes are and how they are used by living systems. It demonstrates how organisms make choices, influencing their behaviour, their development and evolution, and act as agents of natural selection. It presents a novel approach to fundamental philosophical and cultural issues, such as free-will. Reading this book will make you see life in a new light, as a marvellous phenomenon, and in some sense a triumph of evolution. We are not in our genes, our genes are in us.

First published in 1989, Goals, No-Goals and Own Goals presents a stimulating debate between three scientists and three philosophers about the significance and nature of goal-directed and intentional behaviour. At one extreme David McFarland brings into radical question the need for either of these concepts, at least in the scientific study of animal behaviour. At the other extreme, Alan Montefiore argues that such concepts are indispensable to any explication of the meaningful use of language and that we must therefore acknowledge their importance in understanding the nature of human behaviour. Denis Noble uses arguments drawn from computer science and physiology to show that it is incorrect to regard intentions as causes of neural events, even though it is correct to regard intentionality as responsible for our actions. Shawn Lockery outlines how intentional behaviour might be subjected to physiological study. Kathy Wilkes widens the debate by asking some basic questions about the nature of explanation and finally, Daniel Dennett argues how the study of animal behaviour might inform research in Artificial Intelligence. This book will be a useful resource for scholars and researchers of cognitive science, philosophy, psychology, linguistics and physiology.

First published in 1989, Goals, No-Goals and Own Goals presents a stimulating debate between three scientists and three philosophers about the significance and nature of goal-directed and intentional behaviour. At one extreme David McFarland brings into radical question the need for either of these concepts, at least in the scientific study of animal behaviour. At the other extreme, Alan Montefiore argues that such concepts are indispensable to any explication of the meaningful use of language and that we must therefore acknowledge their importance in understanding the nature of human behaviour. Denis Noble uses arguments drawn from computer science and physiology to show that it is incorrect to regard intentions as causes of neural events, even though it is correct to regard intentionality as responsible for our actions. Shawn Lockery outlines how intentional behaviour might be subjected to physiological study. Kathy Wilkes widens the debate by asking some basic questions about the nature of explanation and finally, Daniel Dennett argues how the study of animal behaviour might inform research in Artificial Intelligence. This book will be a useful resource for scholars and researchers of cognitive science, philosophy, psychology, linguistics and physiology.

The Language of Symmetry is a re-assessment of the structure and reach of symmetry, by an interdisciplinary group of specialists from the arts, humanities, and sciences at Oxford University.It explores, amongst other topics:order and chaos in the formation of planetary systemsentropy and symmetry in physicsgroup theory, fractals, and self-similaritysymmetrical structures in western classical musichow biological systems harness disorder to create orderThis book aims to open up the scope of interdisciplinary work in the study of symmetry and is intended for scholars of any background - whether it be science, arts, or philosophy.

The Language of Symmetry is a re-assessment of the structure and reach of symmetry, by an interdisciplinary group of specialists from the arts, humanities, and sciences at Oxford University.It explores, amongst other topics:order and chaos in the formation of planetary systemsentropy and symmetry in physicsgroup theory, fractals, and self-similaritysymmetrical structures in western classical musichow biological systems harness disorder to create orderThis book aims to open up the scope of interdisciplinary work in the study of symmetry and is intended for scholars of any background - whether it be science, arts, or philosophy.

In this thought-provoking book, Denis Noble formulates the theory of biological relativity, emphasising that living organisms operate at multiple levels of complexity and must therefore be analysed from a multi-scale, relativistic perspective. Noble explains that all biological processes operate by means of molecular, cellular and organismal networks. The interactive nature of these fundamental processes is at the core of biological relativity and, as such, challenges simplified molecular reductionism. Noble shows that such an integrative view emerges as the necessary consequence of the rigorous application of mathematics to biology. Drawing on his pioneering work in the mathematical physics of biology, he shows that what emerges is a deeply humane picture of the role of the organism in constraining its chemistry, including its genes, to serve the organism as a whole, especially in the interaction with its social environment. This humanistic, holistic approach challenges the common gene-centred view held by many in modern biology and culture.

Proceedings of the International Symposium on Cardiac Ion Channels and Effects of Taurine on the Heart (Seoul, Korea, 1992)

In The Pacemaker Channels of the Heart, Denis Noble chronicles the fascinating journey of his research into one of biology's most essential functions — the rhythmic beating of the heart. Written by the founder of mathematical heart modelling, this book traces scientific developments spanning over sixty-five years, from the pioneering 1960 heart rhythm model to the sophisticated integrative models of today. This journey follows the evolution of cardiac electrophysiology through the discovery of potassium and slow channels, analytical modelling, and the development of the electrocardiogram.Beyond its technical scope, the book describes a profound shift in biological thinking — from a reductionist, gene-centric view of life to a systems-based understanding of living organisms. In doing so, it addresses major philosophical and scientific debates surrounding the foundations of biology, offering a fresh perspective on why genes alone cannot account for the complexity of life. The book will be of great interest to researchers and students specialising in cardiology, as well as philosophers of science and more general readers, presenting a synthesis of rigorous research, theoretical innovation, and wider reflections on a storied career in the biological sciences.

This is a scientific and philosophical autobiography written around a collection of Denis Noble's most significant papers. It traces a remarkable journey from naïve reductionism to a rigorous systems approach to living systems. It is rigorous because Denis Noble was one of the first biologists to construct computer models of cells and organs of the body. His theoretical work is entirely mathematically based, with no room for ambiguity. Far from the denigration of the systems approach as holistic ‘hand-waving’, his work is now regarded by pharmaceutical companies and regulators as the gold standard of modelling in the development of new medication.Systems Biology is an idea in search of a definition. This book explains why this is true: it is an approach rather than a subject. Denis Noble's work is one of the clearest examples of the systems approach in practice since it reveals the nature of some of the forms of downward causation in multilevel analysis. The story will delight readers who like to see how scientific controversy is resolved, since many of the developments described in each chapter were highly controversial when they occurred.