Peter M. Howley – författare

In recent years there has been an explosion in research on the papillo- maviruses. The viral nature of human warts was first suggested 80 years ago by Ciuffo, who demonstrated transmission using cell-free filtrates. Shope described the first papillomavirus over 50 years ago as the etiologic agent in infectious papillomatosis in rabbits. Subsequent studies by Rous established that benign rabbit papillomas induced by this virus could progress to carcinomas when treated with specific nonviral cofactors. Despite these rich beginnings, the papillomavirus field lay virtually dor- mant until the late 1970s because no one was able to propagate these viruses in culture successfully. In the late 1970s the molecular cloning of the papillomavirus genomes permitted investigators to partially cir- cumvent this obstacle to their progress. The cloning of the viral genomes permitted the standardization of viral reagents and provided sufficient material to begin a systematic evaluation of the biology of this group of viruses.

Selected as a Doody’s Core Title for 2025!Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Fundamentals, Seventh Edition, edited by Drs. Peter Howley and David M. Knipe, along with volume associate editors Drs. Lynn Enquist, Jeffrey I. Cohen, Eric O. Freed, Blossom A. Damania, and Sean P. J. Whelan, focuses on the basic principles of virology and reflects recent advances in this dynamic field.   Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as undergraduate and graduate students interested in virology.    Includes chapters on virus structures, essential viral functions, immune responses to viral infections, viral epidemiology, viral diagnostics, and viral therapies  Up to date discussions of antiviral therapies and vaccine strategies  Features more than 300 full-color illustrations, including key figures for use as lecture slides  Provides quick, flexible access to current information both in print and in an improved eBook format  Discusses virus structure, virus entry, replication, and assembly, virus-host cell interactions, host immune responses and vaccines, antiviral therapeutics, viral persistence and latency for HIV, and mechanisms of viral oncogenesis for HPV, KSHV and the hepatotropic viruses    Newly revised Field’s Virology volumes, available in print and eBook format: • Emerging Viruses  • DNA Viruses  • RNA Viruses  • Fundamental Virology    Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech.

Selected as a Doody's Core Title for 2022 and 2023!Now in four convenient volumes, Fields Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Fields Virology: Emerging Viruses, Seventh Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.  Bundled with the eBook, which will be updated regularly as new information about each virus is available, including coronavirus and COVID-19, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases. Covers both basic science and medical features of each virus, emphasizing viruses of medical importance and interest, while also including other viruses in specific cases where more is known about their mechanisms of replication or pathogenesis. Covers virus evolution, as well as Coronoviridae, Picornaviridae, Enteroviruses, Caliciviridae, Hepatitis C Virus, Filoviridae, Henipaviruses, Orthomyxoviruses, Bunyavirales, Arenaviridae, and much more. Features over 500 full-color illustrations, including key figures for use as lecture slides. Provides quick, flexible access to current information both in print and in an improved eBook format, searchable across all volumes. Discusses virus structure, virus entry, replication, and assembly, virus-host cell interactions, host immune responses and vaccines, antiviral therapeutics, virus evolution and immunization. New and forthcoming Fields Virology volumes, available in print and eBook format, which are sold separately: Emerging Viruses DNA Viruses RNA Viruses Fundamental Viruses Enrich Your eBook Reading ExperienceRead directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: DNA Viruses, Seventh Edition covers the latest information on DNA viruses, how they cause disease, including cancer, how they persist in the body in a latent form, reactivate and spread, new therapeutics and vaccine approaches, as provided in new or extensively revised chapters that reflect these advances in this dynamic field. Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases. Covers both basic science and medical features of each virus, emphasizing viruses of medical importance and interest, while also including other viruses in specific cases where more is known about their mechanisms of replication or pathogenesis.  Covers viruses that cause human cancer such as human papillomaviruses (HPV), Epstein Barr Virus, the Merkel Cell Polyomavirus and hepatitis B virus, and viruses like the herpesviruses that persist in a latent form and can reactivate and cause acute and/or chronic disease. Features more than 400 full-color illustrations, including key figures for use as lecture slides. Provides quick, flexible access to current information both in print and in an improved eBook format. Discusses virus structure, virus entry, replication, and assembly, virus-host cell interactions, host immune responses and vaccines, antiviral therapeutics, viral persistence and latency and viruses as tools for gene therapy and vectors for vaccination.  New and forthcoming Field’s Virology volumes, available in print and eBook format: • Emerging Viruses • DNA Viruses • RNA Viruses • Fundamental Viruses  Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: RNA Viruses, Seventh Edition covers the latest information on RNA viruses, how they cause disease, how they can cause epidemics and pandemics, new therapeutics and vaccine approaches, as provided in new or extensively revised chapters that reflect these advances in this dynamic field.Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.Covers both basic science and medical features of each virus, emphasizing viruses of medical importance and interest, while also including other viruses in specific cases where more is known about their mechanisms of replication or pathogenesisIncludes two new chapters on SARS - Coronavirus 2 covering both basic science and clinical aspects of CoV2 and COVID-19Covers human immunodeficiency virus (HIV), rotaviruses, respiratory syncytial virus (RSV), measles virus, and moreFeatures more than 400 full-color illustrations, including key figures for use as lecture slidesProvides quick, flexible access to current information both in print and in an improved eBook formatDiscusses virus structure, virus entry, replication, and assembly, virus-host cell interactions, host immune responses and vaccines, antiviral therapeutics, viral persistence and latency for HIV, and mechanisms of viral oncogenesis for HTLV-1 and HCVNew and forthcoming Field’s Virology volumes, available in print and eBook format:• Emerging Viruses - 2020• DNA Viruses - 2021• RNA Viruses• Fundamental Virology Enrich Your eBook Reading ExperienceRead directly on your preferred device(s),such as computer, tablet, or smartphone.Easily convert to audiobook,powering your content with natural language text-to-speech.

Fields. Virología: Fundamentos es el cuarto volumen de la emblemática colección Fields. Virología. Esta 7.ª edición, desarrollada por el eminente equipo de autores liderado por los doctores Howley y Knipe, se ha abocado a cubrir los aspectos básicos de la virología, proporcionando, además del contexto histórico, los principios fundamentales, el ingreso y la descapsidación de los virus, la replicación y el ensamblaje víricos y las respuestas inmunitarias del hospedero al virus. Además, se incluyen los capítulos sobre virus de insectos, plantas y bacterias, así como sobre los priones como agentes infecciosos.La serie Fields. Virología es la referencia con mayor autoridad y actualización para virólogos, especialistas en enfermedades infecciosas, microbiólogos y médicos internistas, así como para estudiantes de medicina avanzados que deseen profundizar en la disciplina o seguir una carrera en enfermedades transmisibles. El contenido de este volumen incluye 22 capítulos que abarcan desde los principios hasta la virología diagnóstica, la patogénesis de la infección vírica y la respuesta inmunitaria adaptativa a los virus, fármacos y vacunación, entre otros.

Virus de ADN es el segundo volumen de la 7.a edición de Fields. Virología, la referencia de mayor autoridad en el tan cambiante mundo contemporáneo de la virología. Esta edición cubre la información más reciente sobre los virus de ADN, la fisiopatología de los padecimientos que causan, cómo persisten en el cuerpo en forma latente, se reactivan y se propagan, y los nuevos enfoques terapéuticos y de vacunas. Además, brinda una cobertura amplia que incluye la biología de los virus, su replicación y los aspectos clínicos de familias específicas de virus.Su contenido abarca todos los virus de ADN de importancia médica, incluidos los que infectan a los seres humanos y a los animales. Además, se plantean varias cuestiones temáticas al examinar los virus de ADN. La organización de los capítulos de esta edición es similar a las anteriores, es decir, la mayoría de los virus se presenta en un único capítulo que combina los aspectos básicos y clínicos de este. Para otros, la virología básica relacionada con la replicación y la patogénesis víricas se divide en dos capítulos.Esta 7.ª edición de Fields. Virología. Virus de ADN presentada a todo color, con múltiples ilustraciones clínicas, figuras y tablas, está dirigida a estudiantes y profesionales de la virología, enfermedades infecciosas, microbiología, medicina interna, familiar, epidemiología, investigadores, inmunólogos y otros profesionales en contacto con pacientes con enfermedades de origen viral.