Pranjal Chandra – författare

Nanobioanalytical Approaches to Medical Diagnostics reviews a range of nanobiomaterials and bioanalytical nano-devices for medical diagnostics. Nanobiomaterials and nano-devices are used in various bioanalytical and biochemical systems to provide real-time, point-of-care diagnostics. The specialized properties of nanoparticles allow them to be engineered and adapted to produce the required effect within a bioanalytical or biochemical system - offering targeted and detailed diagnostic results in a range of biomedical applications.

This book covers both traditional biochemical and modern, combined nano-approaches to medical diagnostics. Chapters detail a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including DNA and peptide-based, erythrocyte, microfluidic and more. In addition, sections also look at various different medical diagnostic applications, such as in cancer detection, infectious disease diagnosis and blood glucose sensing.

Over the last few decades, the rapid and vast development of advanced microbial bioresources and metagenomics techniques has completely transformed the field of microbial biotechnology. Our understanding of microbial diversity, evolutionary biology, and microbial interaction with their animal and plant hosts at molecular level has been revolutionized with an abundance of new research.

This new volume, Advances in Microbial Biotechnology: Current Trends and Future Prospect, focuses on the application of microorganisms for several purposes: for plant protection and improvement, for environmental remediation purposes, and for the improvement of human health.

Various applications of microorganisms are covered broadly and have been appropriately reflected in depth in different chapters. The book is divided into four major sections:

The book provides insight into the diverse microorganisms that have been explored and exploited in the development of various applications for agricultural improvements. The book also looks at the application of microbes for the removal of pollutants and the recovery of metals and oils. Also discussed is the detection and exploitation of microorganisms in the diagnosis of human diseases, providing possible holistic approaches to health.

This new volume will provide a wealth of information on new research on the application of microbial biotechnology today.

Over the last few decades, the rapid and vast development of advanced microbial bioresources and metagenomics techniques has completely transformed the field of microbial biotechnology. Our understanding of microbial diversity, evolutionary biology, and microbial interaction with their animal and plant hosts at molecular level has been revolutionized with an abundance of new research.

This new volume, Advances in Microbial Biotechnology: Current Trends and Future Prospect, focuses on the application of microorganisms for several purposes: for plant protection and improvement, for environmental remediation purposes, and for the improvement of human health.

Various applications of microorganisms are covered broadly and have been appropriately reflected in depth in different chapters. The book is divided into four major sections:

The book provides insight into the diverse microorganisms that have been explored and exploited in the development of various applications for agricultural improvements. The book also looks at the application of microbes for the removal of pollutants and the recovery of metals and oils. Also discussed is the detection and exploitation of microorganisms in the diagnosis of human diseases, providing possible holistic approaches to health.

This new volume will provide a wealth of information on new research on the application of microbial biotechnology today.

This book discusses the importance of oxidative stress, related biomarkers, and its diagnostic methods including bio-analytical and advanced detection systems.

Oxidative stress is associated with diminished capacity of a biological system to overcome the overproduction of reactive oxygen species. Since oxidative stress has been suggested as a causative factor in many diseases, its prevention is vital, and there is an urgent need for oxidative stress monitoring using in vitro and in vivo models. Interdisciplinary approaches have lead to the development of various oxidative stress monitoring models for real-world clinical and biomedical applications. The development of such methods requires a broad understanding of biology, chemistry, molecular biology, immunology and microbiology. As such, the book is a valuable resource for students, researchers and clinicians interested in the fundamental as well as applied aspects of oxidative stress associated diseases.

This book presents recent research on cancer detection methods based on nanobiosensors, which offer ultrasensitive point-of-care diagnosis.

Several methods for diagnosing cancer have been discovered and many more are currently being developed. Conventional clinical approaches to detecting cancers are based on a biopsy followed by histopathology, or on the use of biomarkers (protein levels or nucleic acid content). Biopsy is the most widely used technique; however, it is an invasive technique and is not always applicable. Furthermore, biomarker-based detection cannot be relied on when the biomarkers are present in an extremely low concentration in the body fluids and in malignant tissues.

Thus, in recent years highly sensitive and robust new cancer diagnosis techniques have been developed for clinical application, and may offer an alternative strategy for cancer diagnosis. As such, this book gathers the latest point-of-care cancer diagnostic methods and protocols based on biomedical sensors, microfluidics, and integrated systems engineering. It also discusses recent developments and diagnostics tests that can be conducted outside the laboratory in remote areas. These technologies include electrochemical sensors, paper-based microfluidics, and other kit-based diagnostic methods that can be adapted to bring cancer detection and diagnostics to more remote settings around the globe.

Overall, the book provides students, researchers, and clinicians alike a comprehensive overview of interdisciplinary approaches to cancer diagnosis.

This book provides detailed information on the surface and surface chemistry of various biointerfaces for the understanding and development of biosensors, biocompatible devices, and drug delivery systems. It highlights the role of interfacial phenomena towards the behaviour of biomolecules on different surfaces and their significance in recent applications. The book also addresses various surface engineering techniques for the modification of biomaterials that are implemented for improving biocompatibility. It provides an updated scientific concept of various interactions of biological systems with surfaces/modified surfaces at the molecular and cellular level. The chapters include various in-vitro, in-vivo, ex-vivo models to illustrate various aspects of Biointerface Engineering. Finally, the book elucidates troubleshooting strategies and future prospects of Biointerface Engineering in Medical Diagnostics and Drug Delivery.

This book presents the timeline of immunodiagnostics evolution, including advancements in immunological/nucleic acid probes, assay design, labelling techniques, and devices for signal transduction and acquisition. In the past few years, enzyme and nanocatalyst-based immune assays have undergone numerous modifications to enhance their sensitivity and potential for automation. Further, to reduce production costs and the use of laboratory animals, engineering small antibodies and nucleic acid probes (aptamers) has become increasingly popular in the development of novel and powerful bioassays. In light of the notable advancements in immunodiagnostics, this book highlights the combined efforts of clinicians, biotechnologists, material scientists, nanotechnologists and basic scientists in a coherent and highly structured way. The book takes readers on the journey of immunodiagnostic technologies, from their introduction to the present.

This book provides fundamental information on various techniques for the detection of SARS-CoV-2 including reverse transcriptase (RT) PCR, loop-mediated isothermal amplification, immunodiagnostic tests, and CRISPR-Cas. It reviews various testing kits and detection methodologies that are currently being used for the detection of SARS-CoV-2 and examines strategies for the post-treatment detection and monitoring of SARS-CoV-2. Further, it assesses the diagnostic potential of several SARS-CoV-2 proteins; and analyzes their structural determinants and immunogenicity.

In turn, the book evaluates the potential of CRISPR-Cas 12-based assays for the detection of SARS-CoV-2 using RNA extracted from patients. Lastly, it discusses the use of miniaturized biosensors for the detection of other types of coronavirus.