Ralph Muller – författare

Global problems require global information, which satellites can now provide. With ever more sophisticated control methods being developed for infectious diseases, our ability to map spatial and temporal variation in risk is more important than ever. Only then may we plan control campaigns and deliver novel interventions and remedies where the need is greatest, and sustainable success is most likely. This book presents a comprehensive guide to using the very latest methods of surveillance from satellites, including analysing spatial data within geographical information systems, interpreting complex biological patterns, and predicting risk both today and as it may change in the future. Of all infectious disease systems, those that involve free-living invertebrate vectors or intermediate hosts are most susceptible to changing environmental conditions, and have hitherto received most attention from the marriage of analytical biology with this new space technology. Accordingly, this volume presents detailed case studies on malaria, African trypanosomiasis (sleeping sickness), tick-borne infections and helminths (worms). For those who are unfamiliar with this science, and unsure how to start, the book ends with a chapter of practical advice on where to seek hands-on instruction. The lessons to be learned from these studies are applicable to many other epidemiological and ecological problems that face us today, most significantly the preservation of the world's biodiversity. Only book to provide a synthesis of complex biology, quantitative analysis, space technology and practical applications, focused on solving real epidemiological problems on a global scale Broad scope, with methods relevant to subjects ranging from biodiversity to public health Practical advice on relevant courses 24 pages of colour plates

First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies on parasites of major influence, such as Plasmodium falciparum and Trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on various topics including Remote Sensing and Geographical Information Systems in Epidemiology and The Evolution of Parasitism - a phylogenetic persepective.

At the present time, the laboratory mouse has become a central tool for skeletal studies, mainly because of the extensive use of genetic manipulations in this species. Naturally, this widespread use of mice in developmental, bone, joint, tooth, and neurological research calls for detailed anatomical knowledge of the mouse skeleton as a reference for experimental design and phenotyping under a variety of experimental conditions, including genetic manipulations (e.g., transgenic and kno- out mice). Several general treatises on the normal anatomy of the mouse and rat have been published in the previous century. In the absence of adequate technologies, these books describe only the external anatomical features of the different parts of the skeleton. In general, images in these atlases are camera lucida-based line drawings rather than accurate three-dimensional images. Furthermore, so far a systematic two- and three-dimensional description of the internal anatomy of bones, as well as the three-dimensional relationship exhibited in joints, are not available.

This second edition of the popular advanced student textbook (previously published as Worms and Disease: A Manual of Medical Helminthology) has been thoroughly updated and revised since it was first published in 1975. It includes contributions and a chapter by Prof. Derek Wakelin, University of Nottingham, UK. An authoritative handbook covering all human helminth infections with particular emphasis on diagnosis, treatment, clinical manifestations, pathogenesis, epidemiology and control. Practical guidelines are given for estimating the clinical and public significance of helminthiases, vital in areas where the majority of inhabitants are infected with many helminths but only a few are sick.

Consumers, public officials, and even managers of health care and insurance are unhappy about care quality, access, and costs. This book shows that is because efforts to do something about these problems often rely on hope or conjecture, not rigorous evidence of effectiveness. In this book, experts in the field separate the speculative from the proven with regard to how care is rendered, how patients can be in control, how providers should be paid, and how disparities can be reduced - and they also identify the issues for which evidence is currently missing. It provides an antidote to frustration and a clear-eyed guide for forward progress, helping health care and insurance innovators make better decisions on deciding whether to go ahead now based on current evidence, to seek and wait for additional evidence, or to move on to different ideas. It will be useful to practitioners in hospital systems, medical groups, and insurance organizations and can also be used in executive and MBA teaching.

Consumers, public officials, and even managers of health care and insurance are unhappy about care quality, access, and costs. This book shows that is because efforts to do something about these problems often rely on hope or conjecture, not rigorous evidence of effectiveness. In this book, experts in the field separate the speculative from the proven with regard to how care is rendered, how patients can be in control, how providers should be paid, and how disparities can be reduced - and they also identify the issues for which evidence is currently missing. It provides an antidote to frustration and a clear-eyed guide for forward progress, helping health care and insurance innovators make better decisions on deciding whether to go ahead now based on current evidence, to seek and wait for additional evidence, or to move on to different ideas. It will be useful to practitioners in hospital systems, medical groups, and insurance organizations and can also be used in executive and MBA teaching.

Naturally, this widespread use of mice in developmental, bone, joint, tooth, and neurological research calls for detailed anatomical knowledge of the mouse skeleton as a reference for experimental design and phenotyping under a variety of experimental conditions, including genetic manipulations (e.g., transgenic and kno- out mice).

This reference work gives a comprehensive overview about how to fully exploit the potential of bioimaging to characterize tissue regeneration holistically and to gain complementary, multi-scale information about relevant structure, function, dynamics and molecular composition. To keep pace with the highly dynamic nature of the field and fast-developing imaging technology, it is essential to allow its Live Reference version to be updated and dynamic. It guides the reader through real-case biomedical applications organized by chapter and gives a tissue-specific overview on how to best assess parameters of interest. Additionally, all imaging techniques, including emerging modalities, are explained in great detail and enables the reader to understand the physical principles behind each imaging modality. The book provides a unique overview of available biological and (pre)clinical imaging techniques in the field and enables the reader to understand their benefits and limitations for real-case applications. The reader will be equipped with a comprehensive tool to properly chose the most promising technique for her/his biomedical research question - and respond to novel trends due to the dynamic nature of the Live Reference version available online. The book is of high interest to all researchers, physicians, physicists and life scientists working in the field to deepen their theoretical and practical knowledge about bioimaging and about the wide range of tissue-specific biomedical applications. The book is a valuable reference in the field for bioimaging.

Der Band hat zum Ziel, den Arbeitsbereich Lyrikforschung schärfer zu konturieren und ein klar umrissenes Forschungsfeld Lyrikologie zu etablieren. Er dokumentiert die drei Jahre währenden kontinuierlichen Diskussionen des wissenschaftlichen Netzwerks „Lyrikologie" zur Entwicklung einer systematischen Gattungstheorie der Lyrik. In insgesamt sechs Sektionen werden zentrale Arbeitsgebiete einer solchen Lyrikologie abgesteckt: „Typische Merkmale der Lyrik", ,„Methoden der Lyrikanalyse", „Funktionen der Lyrik", „Lyrische Zeitkonzepte", „Lyrik und Raum", „Mündliche/schriftliche Formatierung von Lyrik".