RC Sobti – författare

Microbes are the predominant form of life on the planet due to their broad range of adaptation and versatile nutritional behavior. The ability of some microbes to inhabit hostile environment incompatible with most forms of life means that their habitat defines the extent of the biosphere and delineates the barrier between the biosphere and geosphere. The direct and indirect role of microbes that include bacteria, fungi, actinomycetes, viruses, mycoplasma, and protozoans are very much important in development of modern human society for food, drugs, textiles, agriculture, and environment. Furthermore, microorganisms and their enzyme system are responsible for the degradation of various organic matters. Microbes for Sustainable Development and Bioremediation emphasizes the role of microbes for sustainable development of ecosystem. Environmental microbiology role in biogeochemical cycle and bioremediation of environmental waste is major theme, which comprises the following aspects: Bacterial phytoextraction mechanism of heavy metals by native hyperaccumulator plants from complex waste-contaminated site for eco-restoration Role of microbial enzyme for eco-friendly recycling of industrial waste Field-scale remediation of crude oil–contaminated desert soil and treatment technology Microbial technology for metal recovery from e-waste printed circuit board Impact of genomic data on sustainability of ecosystem Methane monooxygenases: their regulations and applications Role of microbes in environmental sustainability and food preservation This book will be directly beneficial to researchers and classroom students, in areas of biotechnology, environmental microbiology, molecular biology, and environmental engineering with specialized collection of cutting-edge knowledge.

Drawing on contributions from more than thirty scholars and experts in the field, this book examines the role of business as an enabler, as an inhibitor, and ultimately as a co-actor in global sustainability transformations expected over the next few decades.The Role of Business in Global Sustainability Transformations employs several theoretical perspectives and provides abundant examples and cases to discuss a variety of emerging concepts, phenomena, and trends shaping business sustainability. Weaving through the chapters, the editors present core tensions and sources of inertia towards transformative change, and acknowledge that envisioning multiple solutions and pathways are possible and desirable. They advocate for the need to align visions, actions and time horizons between policy, society and business in addressing the interlinked socio-ecological challenges that our society currently faces.This book will be an important resource for scholars and professionals working in the field of sustainability and sustainable business, and a vital educational text for students interested in this discipline.

Drawing on contributions from more than thirty scholars and experts in the field, this book examines the role of business as an enabler, as an inhibitor, and ultimately as a co-actor in global sustainability transformations expected over the next few decades.The Role of Business in Global Sustainability Transformations employs several theoretical perspectives and provides abundant examples and cases to discuss a variety of emerging concepts, phenomena, and trends shaping business sustainability. Weaving through the chapters, the editors present core tensions and sources of inertia towards transformative change, and acknowledge that envisioning multiple solutions and pathways are possible and desirable. They advocate for the need to align visions, actions and time horizons between policy, society and business in addressing the interlinked socio-ecological challenges that our society currently faces.This book will be an important resource for scholars and professionals working in the field of sustainability and sustainable business, and a vital educational text for students interested in this discipline.

This volume is a compilation of 20 articles written by scientists from different parts of the world dealing with various aspects of: repetitive sequences in chromosomes; telomeric sequences and their maintenance by telomerase; chromatin structure and gene activation; centrometric complexity in holocentric chromosomes; translocation frequencies in X and Y chromosomes and evolution of DNA repair mechanisms; cytogenetics of certain groups of animals, such as lepidoptera, fishes and birds; and radiosensitivity as an indicator of predisposition to breast cancer. The molecular genetics of various cancers, such as gastrointestinal, lung, prostate, and bladder are also discussed.

Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics.This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general.The volume comprehensively covers:Emerging technologies for health careVarious aspects of biomedical research toward understanding of pathophysiology of the diseasesAdvances in improvement in diagnostic procedures and therapeutic toolsThe fundamental role of biomedical research in the development of new medicinal products

Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics.This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general.The volume comprehensively covers:Emerging technologies for health careVarious aspects of biomedical research toward understanding of pathophysiology of the diseasesAdvances in improvement in diagnostic procedures and therapeutic toolsThe fundamental role of biomedical research in the development of new medicinal products

High-throughput molecular technologies ("omics") can help to decipher the contributions of different physiological systems and identify candidate molecules that are representative of different physiological pathways thereby allowing the discovery of biomarkers. Notably, the omics technologies along with and computational methods, bioprospecting, and artificial intelligence will continue to lead to better understanding of biological mechanisms that are responsible for physical attributes, or phenotypes. Research breakthroughs obtained through these technologies can be used to enhance productivity of food animals, meet the increasing demand for animal-sourced foods, enhance high-quality nutrient availability, ensure nutrient safety, mitigate the effects of climate variability, and result in new technologies that provide continued improvement in food security worldwide. Such breakthroughs are an urgent necessity because over the past 50 years, there has been an unprecedented increase in the world’s population, which will reach ten billion by the year 2050. Innovative and technological advancements that enhance all aspects of food production will arise from basic, fundamental research. Besides food, animal by-products have found many applications in the fields of pharmaceuticals, cosmetics, and household and industrial products. Hence, the need to ameliorate the productivity, reproductivity, growth performance, and disease resistance in animals has created a worldwide interest in gaining a deeper understanding of animal biology, biotechnology and genomics, and proteomics. The present volume thoroughly discusses the omics studies in domestic and non-domestic animals and their role in mitigation of various challenges ahead. The volume thus focuses on i. Omics (genomics, proteomics, transcriptomics, metabolonomics) technologies in identifying, characterizing biodiversity ii. Role of molecular techniques for improvement of domestic and non-domestic organisms iii. Animal and alternative model systems (using stem cells, tissue engineering, cell free systems, 3D platforms etc.) for studying life phenomenaiv. Genetically modified organisms as factories for the products

COVID-19 was first identified in Wuhan City in December 2019 and spread throughout Hubei Province and other parts of China. After causing significant morbidity and mortality in China, by February 2020, it had spread to numerous other countries, infecting millions of people and causing a large number of deaths across the world. The COVID-19 pandemic put a burden on almost all areas of the world including healthcare systems, education, industry, travel, etc. The pandemic revealed the vulnerability of the world’s healthcare systems and affected healthcare personnel significantly. The virus is able to attack not only the respiratory tract, but almost all the organs including the brain. Impacts on gut biota have also been noticed. The virus has caused both morbidity and mortality in humans without any geographical, cultural, or religious barriers. The emergence of new variants due to mutations in the virus has aggravated the problem. While the delta variant brought a second wave and killed a large number of people due to various factors such as lowering of saturated oxygen in blood and other physiological emergencies, the omicron variant proved to be less lethal. Though the pandemic has subsided, the emergence of the subvariants BA1 and BA2 and now their hybrids has started to increase the number of cases at exponential levels and has forced new lockdown measures in places such as China. As the conditions laid down to combat the pandemic have been relaxed, the virus may reach other countries and cause additional countries to resort to lockdown again. COVID-19 became the focus of the scientific community with the aim of developing new drugs, repurposing available drugs to be used against the virus, and developing a series of vaccines in a short time. The mild effect of omicron might have been due to the extensive vaccination programmes carried out in various countries. However, there is genuine fear that newly emerging variants may evade the immune system and cause damage to the body.This book highlights the impact of COVID-19 on science, industry, and healthcare systems. The chapters included in the volume come from dedicated experts belonging to basic sciences, biotechnology, pharmaceutical sciences, and other fields of sciences. These include discussions on how the virus evolves and attacks various organs in the body. A separate chapter explains the emergence of various strains of virus. The preparedness of hospitals and healthcare workers as well as different agencies such as DRDO to face the challenges posed by virus is also discussed. The way scientists and technologists developed new techniques to detect and control the virus have also been highlighted including a chapter on the development of vaccines to control the pandemic.This book is a key resource for students, teachers, medical personnel, administrators, and the public as a whole.

COVID-19 was first identified in Wuhan City in December 2019 and spread throughout Hubei Province and other parts of China. After causing significant morbidity and mortality in China, by February 2020, it had spread to numerous other countries, infecting millions of people and causing a large number of deaths across the world. The COVID-19 pandemic put a burden on almost all areas of the world including healthcare systems, education, industry, travel, etc. The pandemic revealed the vulnerability of the world’s healthcare systems and affected healthcare personnel significantly. The virus is able to attack not only the respiratory tract, but almost all the organs including the brain. Impacts on gut biota have also been noticed. The virus has caused both morbidity and mortality in humans without any geographical, cultural, or religious barriers. The emergence of new variants due to mutations in the virus has aggravated the problem. While the delta variant brought a second wave and killed a large number of people due to various factors such as lowering of saturated oxygen in blood and other physiological emergencies, the omicron variant proved to be less lethal. Though the pandemic has subsided, the emergence of the subvariants BA1 and BA2 and now their hybrids has started to increase the number of cases at exponential levels and has forced new lockdown measures in places such as China. As the conditions laid down to combat the pandemic have been relaxed, the virus may reach other countries and cause additional countries to resort to lockdown again. COVID-19 became the focus of the scientific community with the aim of developing new drugs, repurposing available drugs to be used against the virus, and developing a series of vaccines in a short time. The mild effect of omicron might have been due to the extensive vaccination programmes carried out in various countries. However, there is genuine fear that newly emerging variants may evade the immune system and cause damage to the body.This book highlights the impact of COVID-19 on science, industry, and healthcare systems. The chapters included in the volume come from dedicated experts belonging to basic sciences, biotechnology, pharmaceutical sciences, and other fields of sciences. These include discussions on how the virus evolves and attacks various organs in the body. A separate chapter explains the emergence of various strains of virus. The preparedness of hospitals and healthcare workers as well as different agencies such as DRDO to face the challenges posed by virus is also discussed. The way scientists and technologists developed new techniques to detect and control the virus have also been highlighted including a chapter on the development of vaccines to control the pandemic.This book is a key resource for students, teachers, medical personnel, administrators, and the public as a whole.

COVID-19 is a highly contagious viral illness caused by severe acute respiratory syndrome SARSCoV-2. It has had a devastating effect on the world’s demographics with high morbidity and mortality worldwide. After the influenza pandemic of 1918, it has emerged as the most consequential global health crisis. After the first cases of this predominantly respiratory viral illness were first reported in Wuhan, Hubei Province, China, in late December 2019, SARS-CoV- 2 rapidly disseminated across the world in a short span of time, compelling the World Health Organization (WHO) to declare it a global pandemic on March 11, 2020. The outbreak of COVID-19 has proven to be a worldwide unprecedented disaster. It has physically, psychologically, socially, and economically afflicted billions of people across the globe. Its transmission is significantly high. Serious postrecovery has been noticed in a large number of people. The virus is highly mutable and new and new strains are appearing, and many of them such as delta, BA1 and BA2 subvariants as well as their hybrids have been considered by the WHO as concerning. The virus has exhibited deleterious impacts on bodily systems other than the respiratory system (primary target) such as the brain, hematological system, liver, kidneys, endocrine system, etc. Right after its declaration as a pandemic by the WHO in March 2020, governments in various countries declared lockdowns to combat the spread of disease, causing major disruption to the lives of billions of people.Besides the impact on health and healthcare systems, education was changed with the introduction of online and or hybrid systems to help students continue to learn. Though the pandemic has subsided now, the emergence of new variants continues and lifestyle changes such as online learning and work from home have continued.Researchers who successfully mitigated the negative impact of social media and effectively used it for acceptance of medicinal or non-medicinal measures during pandemics by developing a realtime information sharing system and assembling a multidisciplinary team of experts to collect and analyze data from a variety of social media platforms across the global diaspora to better understand people’s perceptions and attitudes, as well as to spot early warning signs of error and correct them before they proliferate. They also emphasized the necessity of addressing people’s perceptions in order to increase awareness and education, so that social media may be used to promote public trust collaboration, and improved adherence to epidemic control measures. In totality the pandemic affected the environment and ecosystem as a whole positively due to a decrease in vehicles on roads and less movement of persons from one place to another. However, medical waste was increased and new measures were needed to handle it. People have had to change their habits in everyday life in order to live with the pandemic and protect themselves and others.This volume focuses on the implications of COVID-19 on education, environment, and lifestyle. It includes chapters on the transformation of education systems and introduction of hybrid modes of education, impact on environment, management of solid wastes, and development of innovative gadgets and architectural designs to help deal with the pandemic. Other chapters cover diet, family systems, and adoption of new norms in pandemic times.This book will be a valued resource for students, teachers, and researchers of social science and science as well as public health workers.

COVID-19 is a highly contagious viral illness caused by severe acute respiratory syndrome SARSCoV-2. It has had a devastating effect on the world’s demographics with high morbidity and mortality worldwide. After the influenza pandemic of 1918, it has emerged as the most consequential global health crisis. After the first cases of this predominantly respiratory viral illness were first reported in Wuhan, Hubei Province, China, in late December 2019, SARS-CoV- 2 rapidly disseminated across the world in a short span of time, compelling the World Health Organization (WHO) to declare it a global pandemic on March 11, 2020. The outbreak of COVID-19 has proven to be a worldwide unprecedented disaster. It has physically, psychologically, socially, and economically afflicted billions of people across the globe. Its transmission is significantly high. Serious postrecovery has been noticed in a large number of people. The virus is highly mutable and new and new strains are appearing, and many of them such as delta, BA1 and BA2 subvariants as well as their hybrids have been considered by the WHO as concerning. The virus has exhibited deleterious impacts on bodily systems other than the respiratory system (primary target) such as the brain, hematological system, liver, kidneys, endocrine system, etc. Right after its declaration as a pandemic by the WHO in March 2020, governments in various countries declared lockdowns to combat the spread of disease, causing major disruption to the lives of billions of people.Besides the impact on health and healthcare systems, education was changed with the introduction of online and or hybrid systems to help students continue to learn. Though the pandemic has subsided now, the emergence of new variants continues and lifestyle changes such as online learning and work from home have continued.Researchers who successfully mitigated the negative impact of social media and effectively used it for acceptance of medicinal or non-medicinal measures during pandemics by developing a realtime information sharing system and assembling a multidisciplinary team of experts to collect and analyze data from a variety of social media platforms across the global diaspora to better understand people’s perceptions and attitudes, as well as to spot early warning signs of error and correct them before they proliferate. They also emphasized the necessity of addressing people’s perceptions in order to increase awareness and education, so that social media may be used to promote public trust collaboration, and improved adherence to epidemic control measures. In totality the pandemic affected the environment and ecosystem as a whole positively due to a decrease in vehicles on roads and less movement of persons from one place to another. However, medical waste was increased and new measures were needed to handle it. People have had to change their habits in everyday life in order to live with the pandemic and protect themselves and others.This volume focuses on the implications of COVID-19 on education, environment, and lifestyle. It includes chapters on the transformation of education systems and introduction of hybrid modes of education, impact on environment, management of solid wastes, and development of innovative gadgets and architectural designs to help deal with the pandemic. Other chapters cover diet, family systems, and adoption of new norms in pandemic times.This book will be a valued resource for students, teachers, and researchers of social science and science as well as public health workers.

This reference book examines the role of biotechnological innovations in achieving global health targets, addressing disease burdens, and fostering a sustainable healthcare ecosystem for promoting good health and wellbeing. It covers a wide range of topics including the evolution of healthcare technologies, epidemiological approaches in predictive medicine, management of diseases across different organs, emerging technologies in drug development, design, and delivery systems, vaccination strategies; technologies for tackling pandemics; and biotechnological applications in regenerative medicine and tissue engineering. Further, the book discusses different biotechnological advances in geriatric medicine and innovative therapies for age-related diseases. It also explores the intersection of biotechnology with maternal and child health and emphasizes the One Health approach in preventing and controlling zoonotic diseases. This book is intended for researchers, academics, and professionals in biotechnology, healthcare, and public health.Key FeaturesDiscusses the potential of biotechnological innovations in achieving sustainable development goals towards good health and wellbeingProvides an in-depth analysis of the latest biotechnological innovations in pharmaceuticals, diagnostics, medical devices, regenerative medicine, and personalized medicineExamines the role of biotechnology in addressing major global health challenges, such as infectious diseases, non-communicable diseases, and maternal and child healthReviews biotechnological advances in geriatric medicine, age-related diseases, longevity, anti-aging biotechnologies, and innovative drug delivery systemsPresents the vast potential of biotechnological applications in regenerative medicine and tissue engineeringAssesses ethical, legal, and social implications of biotechnological advancements in healthcare and their impact on individuals, societies, and sustainable development

Flow cytometry has rapidly evolved into a technique for rapid analysis of DNA content, cellular marker expression and electronic sorting of cells of interest for further investigations. Flow cytometers are being extensively used for monitoring of cellular DNA content, phenotype expression, drug transport, calcium flux, proliferation and apoptosis. Phenotypic analysis of marker expression in leukemic cells has become an important tool for diagnostic and therapeutic monitoring of patients. Recent studies have explored the use of flow cytometry for monitoring hormone receptor expression in human solid tumors and for studies in human genomics. Contributions in the current volume are based on presentations made at the First Indo-US workshop on Flow Cytometry in which experts from USA, UK and India discussed applications of flow cytometry in biological and medical research. This book will be of interest to post graduates and researchers in the fields of pathology, cytology, cell biology and molecular biology.

Flow cytometry has rapidly evolved into a technique for rapid analysis of DNA content, cellular marker expression and electronic sorting of cells of interest for further investigations. Flow cytometers are being extensively used for monitoring of cellular DNA content, phenotype expression, drug transport, calcium flux, proliferation and apoptosis. Phenotypic analysis of marker expression in leukemic cells has become an important tool for diagnostic and therapeutic monitoring of patients. Recent studies have explored the use of flow cytometry for monitoring hormone receptor expression in human solid tumors and for studies in human genomics. Contributions in the current volume are based on presentations made at the First Indo-US workshop on Flow Cytometry in which experts from USA, UK and India discussed applications of flow cytometry in biological and medical research. This book will be of interest to post graduates and researchers in the fields of pathology, cytology, cell biology and molecular biology.

This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology.

This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology. The book highlights the applications of artificial intelligence in the diagnosis of infectious diseases and examines the role of system biology approaches for understanding human complexity, variability, and its influence on health and diseases. It presents the applications of flow cytometry in monitoring the progression and treatment of disease. It covers emerging technologies in cancer research, including CRISPR-Cas9, NGS, and nanotechnology. This book is a useful source of information for clinical researchers, basic scientists, biomedical engineers, and computational biologists.

The second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure.

The second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells.  It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.

This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning.

This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning.

This book examines the role of human microbiome in human health and diseases. The initial chapters present tools for genetic manipulation of gut microbiota and the therapeutic applications of engineered microbiota. They discuss the interaction between human microbiota and host in defining the prominent role of microbes in the development and progression of major human diseases. The book also summarizes the current applications and trends for the development, production and analytical characterization of recombinant therapeutic proteins in microbial systems. It also reviews the role of microbes in the production of vaccines and antibiotics. Further, the book presents bacterial products, including proteins, enzymes, immunotoxins and secondary metabolites, that target cancer cells and cause tumour regression. The chapters also discuss the critical role of gut microbiota dysbiosis in the pathogenesis of autoimmune disease and in bowel-related diseases. Towards the end, the book exploresthe role of intestinal microbiota in metabolic health and the pathogenesis of common metabolic disorders. It presents state-of-the-art insights into important aspects of United Nations—Sustainable Developmental Goal 3.