Aastha Sobti – författare

Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case. This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research. Provides up-to-date information on current molecular biomarkers research for cancer Presents new diagnostic techniques using biomarkers that can leverage quicker results that can be essential for patient's survivorship Discusses several novel therapeutics applied to specific cancer types, such as head and neck, oral, GI tract, breast, lung and hepatocellular carcinomas

Biomarkers in Cancer Detection and Monitoring of Therapeutics, Volume One, Discovery and Technologies discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancer types. This first volume in the series focuses on techniques and approaches recently developed to assist in the decision of which biomarker to use for specific conditions. Topics covered include circulating tumor cells and circulating tumor DNA, exomes, tumor microenvironment, gene editing, artificial intelligence and robotics. In addition, the book discusses the development and applications of organoids and precision medicine.This book will be a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of biomarkers in cancer research.Provides up-to-date information on current molecular biomarkers research for cancerPresents basic research aspects and novel technologies applied in the discovery of new biomarkersDiscusses several technologies, including artificial intelligence, robotics, data mining, gene editing, omics and their applicability for specific cancer types

Molecular Medicine and Biomedical Research in the Era of Precision Medicine: New Technologies and Personalized Drug Therapies for Patient Care provides researchers with an extensive overview of recent advances in molecular biology impacting the development of targeted therapies. The book delivers insights into the pathobiological and pathogenetic mechanisms of various diseases, providing a detailed study of the latest personalized interventions to be implemented across such conditions. It covers a range of technologies, including RNA-sequencing, AI, Machine Learning, gene therapy, omics and nanotechnology, delving into their clinical applications across various diseases.The book also tackles targeted treatments of different disease types, including acute, chronic, infectious and noncommunicable diseases. Future perspectives are also covered, providing an in-depth study across molecular medicine, drug discovery and delivery, disease diagnosis and prevention, and therapeutic interventions, and acting as an invaluable interdisciplinary reference for researchers across the biomedical sciences.

Public and Environmental Health: Shaping Tomorrow for a Sustainable Future offers an in-depth exploration of the latest developments, strategies, and research in these intertwined fields, providing readers with a comprehensive understanding of how to improve health outcomes through innovative approaches and informed public policy. Sections address how individuals and communities can make informed health decisions for better health outcomes, present the myriad of challenges the environment poses, including climate change, and how global cooperation, policy interventions, and sustainable practices can help improve outcomes for communities across the world. Additional content details how surveillance and epidemiological research are foundational to public health at both a national and international level, allowing authorities to respond promptly to threats, allocate resources effectively, and implement targeted interventions. Written by experts from across the globe, this book is ideal for public health administrators, researchers, students, and NGOs involved in public health programs and the environment.Presents existing knowledge on emerging technologies to predict and evaluate concerns arising from climate, demographic, and geological changesDiscusses contemporary issues on organ-based health such as brain, eyes, ears, nose, heart, kidney, and bones respective to treatment and preventionCovers additional topics on aging and the potential for future pandemics

Advanced Technologies for Disease Intervention: Innovations Across Precision Medicine, Nutrition and Holistic Therapies, Two Volume Set investigates current and emerging advances in disease detection, diagnosis, treatment and prevention, and how molecular medicine and biotechnology have contributed to this changing landscape. Volume One focuses on sustainable health practices through biotechnology, exploring traditional health systems, diagnostic innovations, and integrative therapies. Key topics include: the role of traditional medicine and practices in sustainable health; contemporary and emerging technologies such as aptamer diagnostics, telemedicine, nanomaterials and AI in healthcare, and much more.Volume Two then delves deeper into emerging technologies for disease intervention, focusing on drug development, delivery systems, nutrition, and natural products for health. Themes explored here include: developments and trends in drug discovery; drug repurposing; contemporary drug delivery systems; phototherapeutics; personalized drug delivery; innovations in vaccine development; the role of nutraceuticals in disease prevention; and the use of natural products and herbal interventions for sustainable health.Provides an in-depth compendium of emerging biotechnological therapies and diagnostic innovations, covering the latest advances in molecular medicine and biopharmaceutical researchDelivers interdisciplinary perspectives, fostering collaboration across various research fields to enhance patient care strategiesConsiders both traditional therapies and cutting-edge innovations in the pursuit of sustainable health, from yoga practices, nutraceuticals and natural supplements, to AI, regenerative medicine, recombinant antigens, and genome editing technologies

Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics.This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general.The volume comprehensively covers:Emerging technologies for health careVarious aspects of biomedical research toward understanding of pathophysiology of the diseasesAdvances in improvement in diagnostic procedures and therapeutic toolsThe fundamental role of biomedical research in the development of new medicinal products

Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics.This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general.The volume comprehensively covers:Emerging technologies for health careVarious aspects of biomedical research toward understanding of pathophysiology of the diseasesAdvances in improvement in diagnostic procedures and therapeutic toolsThe fundamental role of biomedical research in the development of new medicinal products

High-throughput molecular technologies ("omics") can help to decipher the contributions of different physiological systems and identify candidate molecules that are representative of different physiological pathways thereby allowing the discovery of biomarkers. Notably, the omics technologies along with and computational methods, bioprospecting, and artificial intelligence will continue to lead to better understanding of biological mechanisms that are responsible for physical attributes, or phenotypes. Research breakthroughs obtained through these technologies can be used to enhance productivity of food animals, meet the increasing demand for animal-sourced foods, enhance high-quality nutrient availability, ensure nutrient safety, mitigate the effects of climate variability, and result in new technologies that provide continued improvement in food security worldwide. Such breakthroughs are an urgent necessity because over the past 50 years, there has been an unprecedented increase in the world’s population, which will reach ten billion by the year 2050. Innovative and technological advancements that enhance all aspects of food production will arise from basic, fundamental research. Besides food, animal by-products have found many applications in the fields of pharmaceuticals, cosmetics, and household and industrial products. Hence, the need to ameliorate the productivity, reproductivity, growth performance, and disease resistance in animals has created a worldwide interest in gaining a deeper understanding of animal biology, biotechnology and genomics, and proteomics. The present volume thoroughly discusses the omics studies in domestic and non-domestic animals and their role in mitigation of various challenges ahead. The volume thus focuses on i. Omics (genomics, proteomics, transcriptomics, metabolonomics) technologies in identifying, characterizing biodiversity ii. Role of molecular techniques for improvement of domestic and non-domestic organisms iii. Animal and alternative model systems (using stem cells, tissue engineering, cell free systems, 3D platforms etc.) for studying life phenomenaiv. Genetically modified organisms as factories for the products

COVID-19 was first identified in Wuhan City in December 2019 and spread throughout Hubei Province and other parts of China. After causing significant morbidity and mortality in China, by February 2020, it had spread to numerous other countries, infecting millions of people and causing a large number of deaths across the world. The COVID-19 pandemic put a burden on almost all areas of the world including healthcare systems, education, industry, travel, etc. The pandemic revealed the vulnerability of the world’s healthcare systems and affected healthcare personnel significantly. The virus is able to attack not only the respiratory tract, but almost all the organs including the brain. Impacts on gut biota have also been noticed. The virus has caused both morbidity and mortality in humans without any geographical, cultural, or religious barriers. The emergence of new variants due to mutations in the virus has aggravated the problem. While the delta variant brought a second wave and killed a large number of people due to various factors such as lowering of saturated oxygen in blood and other physiological emergencies, the omicron variant proved to be less lethal. Though the pandemic has subsided, the emergence of the subvariants BA1 and BA2 and now their hybrids has started to increase the number of cases at exponential levels and has forced new lockdown measures in places such as China. As the conditions laid down to combat the pandemic have been relaxed, the virus may reach other countries and cause additional countries to resort to lockdown again. COVID-19 became the focus of the scientific community with the aim of developing new drugs, repurposing available drugs to be used against the virus, and developing a series of vaccines in a short time. The mild effect of omicron might have been due to the extensive vaccination programmes carried out in various countries. However, there is genuine fear that newly emerging variants may evade the immune system and cause damage to the body.This book highlights the impact of COVID-19 on science, industry, and healthcare systems. The chapters included in the volume come from dedicated experts belonging to basic sciences, biotechnology, pharmaceutical sciences, and other fields of sciences. These include discussions on how the virus evolves and attacks various organs in the body. A separate chapter explains the emergence of various strains of virus. The preparedness of hospitals and healthcare workers as well as different agencies such as DRDO to face the challenges posed by virus is also discussed. The way scientists and technologists developed new techniques to detect and control the virus have also been highlighted including a chapter on the development of vaccines to control the pandemic.This book is a key resource for students, teachers, medical personnel, administrators, and the public as a whole.

COVID-19 was first identified in Wuhan City in December 2019 and spread throughout Hubei Province and other parts of China. After causing significant morbidity and mortality in China, by February 2020, it had spread to numerous other countries, infecting millions of people and causing a large number of deaths across the world. The COVID-19 pandemic put a burden on almost all areas of the world including healthcare systems, education, industry, travel, etc. The pandemic revealed the vulnerability of the world’s healthcare systems and affected healthcare personnel significantly. The virus is able to attack not only the respiratory tract, but almost all the organs including the brain. Impacts on gut biota have also been noticed. The virus has caused both morbidity and mortality in humans without any geographical, cultural, or religious barriers. The emergence of new variants due to mutations in the virus has aggravated the problem. While the delta variant brought a second wave and killed a large number of people due to various factors such as lowering of saturated oxygen in blood and other physiological emergencies, the omicron variant proved to be less lethal. Though the pandemic has subsided, the emergence of the subvariants BA1 and BA2 and now their hybrids has started to increase the number of cases at exponential levels and has forced new lockdown measures in places such as China. As the conditions laid down to combat the pandemic have been relaxed, the virus may reach other countries and cause additional countries to resort to lockdown again. COVID-19 became the focus of the scientific community with the aim of developing new drugs, repurposing available drugs to be used against the virus, and developing a series of vaccines in a short time. The mild effect of omicron might have been due to the extensive vaccination programmes carried out in various countries. However, there is genuine fear that newly emerging variants may evade the immune system and cause damage to the body.This book highlights the impact of COVID-19 on science, industry, and healthcare systems. The chapters included in the volume come from dedicated experts belonging to basic sciences, biotechnology, pharmaceutical sciences, and other fields of sciences. These include discussions on how the virus evolves and attacks various organs in the body. A separate chapter explains the emergence of various strains of virus. The preparedness of hospitals and healthcare workers as well as different agencies such as DRDO to face the challenges posed by virus is also discussed. The way scientists and technologists developed new techniques to detect and control the virus have also been highlighted including a chapter on the development of vaccines to control the pandemic.This book is a key resource for students, teachers, medical personnel, administrators, and the public as a whole.

This book offers a comprehensive overview of fundamental principles and the latest applications in cell biology and regenerative medicine, beginning with the foundational concepts of cell theory. It discusses the various types of cells and their defining characteristics, and dynamic processes of cell division, differentiation, dedifferentiation, proliferation, and apoptosis. The text also introduces the basics of embryo development and delve into the applications of induced pluripotent stem cells, cancer stem cells, tissue-specific niches, and the innovative techniques for editing stem cells. Additionally, the book explores the stem cell niche and its surrounding microenvironment, along with the complex interactions between stem cells and the immune system. It underscores the therapeutic potential of stem cells in treating neurodegenerative diseases, facilitating cardiovascular regeneration, enhancing skin regeneration and wound healing, and improving orthopedic applications. Furthermore, the book examines the use of stem cells in ocular therapies, dental, and craniofacial regeneration. It provides an overview of the regulatory frameworks governing stem cell research, outlines the principles of tissue engineering, and discusses the development of organ-on-a-chip models. This book is an essential resource for students, researchers, and professionals in cell biology and regenerative medicine.Key Features:· Provides extensive overview of fundamental cell biology principles, the latest advancements in regenerative medicine.· Presents therapeutic potential of various types of stem cells, including embryonic stem cells, induced pluripotent stem cells, and cancer stem cells.· Addresses the regulatory landscapes and the ethical issues related to use of stem cell therapy.· Discusses cutting-edge techniques for editing stem cells, principles of tissue engineering, and the development of organ-on-a-chip models.· Delves into the dynamic cellular processes such as division, differentiation, dedifferentiation, proliferation, and apoptosis.

This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology.

This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology. The book highlights the applications of artificial intelligence in the diagnosis of infectious diseases and examines the role of system biology approaches for understanding human complexity, variability, and its influence on health and diseases. It presents the applications of flow cytometry in monitoring the progression and treatment of disease. It covers emerging technologies in cancer research, including CRISPR-Cas9, NGS, and nanotechnology. This book is a useful source of information for clinical researchers, basic scientists, biomedical engineers, and computational biologists.

The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. It also delineates the association of severe disease with high blood plasma levels of inflammatory cytokines and inflammatory markers in SARS-CoV-2 infection.

The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. It also delineates the association of severe disease with high blood plasma levels of inflammatory cytokines and inflammatory markers in SARS-CoV-2 infection.

This book highlights the clinical applications of biomarkers are extensive for cancer risk assessment, screening and early detection of cancer, accurate diagnosis, patient prognosis, prediction of response to therapy, and cancer surveillance and monitoring response.