Richard Heller - Böcker

Evidence based medicine has had a major impact on clinical practice. There is an urgent need for the Public Health community to further develop its own evidence base as many interventions are introduced, unchallenged with no hope of evaluation as the tools for this do not exist.This well structured text aims to provide the tools to achieve this aim. Mindful of the varying needs of students, practitioners and policy makers, the author highlights key take home messages for each and provides practical methods, and their theoretical basis, for applying evidence to the field of Public Health. Some of the methods are well established, others are newly developed by the author and colleagues. The book is aimed at all health students and practitioners, at whatever level, with the hope that the reader will apply these methods to their thinking, research and practice.

Electroporation gene therapy, or gene electrotransfer, has evolved greatly over the last few decades as a result of the remarkable progress in genetic sequencing, gene array analysis, gene cloning, gene expression detection, DNA manufacture and discovery and synthesis of siRNA. Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition provides in-depth knowledge on the delivery of naked DNA and small-interfering RNA (siRNA) to the targeted cells, tissues, and animals for prevention and treatment of disease. It builds on the success of the first edition and on the progress made in siRNA delivery and DNA vaccines for large animals as well as discovery of electroporation applications for the fragile tissues and for internal organs. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition aims to provide not only comprehensive coverage of the basic theory and practical application of electroporation siRNA therapy, gene therapy, and vaccine, but also elaborates on the most current views from the experts in this field, serving as an invaluable resource for investigators both in and outside of this field.

Following Peter Oborne's award-winning global success with Wounded Tiger: A History of Cricket in Pakistan comes a new volume, written with Richard Heller, to celebrate the extraordinary story of Pakistan cricket.In White on Green, we discover a rich tapestry of stories about cricket in all its forms that will fascinate all who want to understand more about that country. We hear from the players of Dera Ismail Khan, who appeared when their side lost by a world-record margin of an innings and 851 runs; and from the Khan sisters, who helped develop the women's game in Pakistan, despite the threats from those who believed their actions to be immoral. But we also hear from the greats of Pakistan cricket, past and present, who provide a revealing picture of the special challenges they have faced, both at home and abroad.Written with great warmth, affection and insight, White on Green is an evocative portrait of a country that is too often condemned and too little understood by outsiders. It shows how the spirit of cricket can help overcome the most difficult environments and bring people together.

Electroporation gene therapy, or gene electrotransfer, has evolved greatly over the last few decades as a result of the remarkable progress in genetic sequencing, gene array analysis, gene cloning, gene expression detection, DNA manufacture and discovery and synthesis of siRNA. Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition provides in-depth knowledge on the delivery of naked DNA and small-interfering RNA (siRNA) to the targeted cells, tissues, and animals for prevention and treatment of disease. It builds on the success of the first edition and on the progress made in siRNA delivery and DNA vaccines for large animals as well as discovery of electroporation applications for the fragile tissues and for internal organs. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition aims to provide not only comprehensive coverage of the basic theory and practical application of electroporation siRNA therapy, gene therapy, and vaccine, but also elaborates on the most current views from the experts in this field, serving as an invaluable resource for investigators both in and outside of this field.

*CHARTING THE RISE AND FALL OF FIRST-CLASS CRICKET: WHAT COMES NEXT?‘A remarkable account of cricket’s fascinating journey from its origins ... to the present day.’ Ehsan Mani, former President of the ICCIn its early forms in the 18th century, cricket was a commercial entertainment, a vehicle for gambling alongside cock-fighting or wrestling. In the Victorian era, the sport was recreated as a means of keeping order in England’s public schools and increasingly allied with ideas of virtue and manliness. Exported by empire loyalists, cricket took root across the globe – thriving in some countries, indelibly linked with racism and colonialism in others.From Australia to the Caribbean to Afghanistan, Oborne and Heller explore cricket’s expansion and its later role in decolonisation, education and politics. They argue that in recent years the game – dominated by the wealth and scale of franchise cricket – has come full circle, less a sport than a commercial enterprise once more. In consequence, they believe it is in crisis. As big money has taken over the game, is cricket losing its integrity and meaning?Comprehensive in scope and drawing on contemporary scholarship, this masterful account is an essential read for cricket fans everywhere. Praise for Full Circle‘A proper, meaty history, independent in perspective, global in its sweep and trenchant in its judgements.’ Gideon Haigh‘A truly global history of cricket, that draws on a wide range of sources and is itself elegantly written.’ Ramachandra Guha, author of The Commonwealth of Cricket‘[An] encyclopaedic journey through the history of the game.’ Fazeer Mohammed, cricket commentator and journalist

THREE SOULS. TWO THOUSAND YEARS. ONE TRUTH.A worldwide conspiracy thriller for the millions of fans of The Da Vinci Code who’ve been left thirsting for more…Just one man can crack the code to the greatest mystery the world has ever known – if he survives…36AD:Micah – Jesus' friend, trusted confidant, and the 13th Apostle – inscribes a message, upon which mankind's fate would one day be determined.Present day:Internet forensic specialist, Gil Pearson, is recruited to decipher an ancient diary and reveal Micah's hidden message, which may lead to the most mysterious of the Dead Sea Scrolls. Working with the enigmatic Sabbie Karaim, Gil becomes embroiled in an international mystery spanning two thousand years, and for which others would gladly give their lives – or, more willingly, take his.

This book focuses on bioelectrics, a new multidisciplinary field encompassing engineering and biology with applications to the medical, environmental, food, energy, and biotechnological fields. At present, 15 universities and institutes in Japan, the USA and the EU comprise the International Consortium of Bioelectrics, intended to advance this novel and important research field. This book will serve as an introductory resource for young scientists and also as a textbook for use by both undergraduate and graduate students – the world’s first such work solely devoted to bioelectrics.