Rob Phillips – författare

A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena.Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons.Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.

An essential introduction to the physics of active matter and its application to questions in biologyIn recent decades, the theory of active matter has emerged as a powerful tool for exploring the differences between living and nonliving states of matter. The Restless Cell provides a self-contained, quantitative description of how the continuum theory of matter has been generalized to account for the complex and sometimes counterintuitive behaviors of living materials.Christina Hueschen and Rob Phillips begin by illustrating how classical field theory has been used by physicists to describe the transport of matter by diffusion, the elastic deformations of solids, and the flow of fluids. Drawing on physical insights from the study of diffusion, they introduce readers to the continuum theory protocol—a step-by-step framework for developing equations that describe matter as a continuum—and show how these methods and concepts can be generalized to the study of living, energy-consuming matter. Hueschen and Phillips then present a range of engaging biological case studies across scales, such as the symmetry breaking that occurs in developing embryos, the perpetual flows that take place in giant algal cells, and the herding of wildebeest on the plains of the Serengeti.An essential resource for students and researchers in biological physics and quantitative biology, The Restless Cell gives complete derivations of all calculations and features illustrations by Nigel Orme that seamlessly bridge conceptual models and continuum descriptions of living matter.

How can novice e-learning researchers and postgraduate learners develop rigorous plans to study the effectiveness of technology-enhanced learning environments? How can practitioners gather and portray evidence of the impact of e-learning? How can the average educator who teaches online, without experience in evaluating emerging technologies, build on what is successful and modify what is not?

By unpacking the e-learning lifecycle and focusing on learning, not technology, Evaluating e-Learning attempts to resolve some of the complexity inherent in evaluating the effectiveness of e-learning. The book presents practical advice in the form of an evaluation framework and a scaffolded approach to an e-learning research study, using divide-and-conquer techniques to reduce complexity in both design and delivery. It adapts and builds on familiar research methodology to offer a robust and accessible approach that can ensure effective evaluation of a wide range of innovative initiatives, including those covered in other books in the Connecting with e-Learning series.

Readers will find this jargon-free guide is a must-have resource that provides the proper tools for evaluating e-learning practices with ease.

How can novice e-learning researchers and postgraduate learners develop rigorous plans to study the effectiveness of technology-enhanced learning environments? How can practitioners gather and portray evidence of the impact of e-learning? How can the average educator who teaches online, without experience in evaluating emerging technologies, build on what is successful and modify what is not?

By unpacking the e-learning lifecycle and focusing on learning, not technology, Evaluating e-Learning attempts to resolve some of the complexity inherent in evaluating the effectiveness of e-learning. The book presents practical advice in the form of an evaluation framework and a scaffolded approach to an e-learning research study, using divide-and-conquer techniques to reduce complexity in both design and delivery. It adapts and builds on familiar research methodology to offer a robust and accessible approach that can ensure effective evaluation of a wide range of innovative initiatives, including those covered in other books in the Connecting with e-Learning series.

Readers will find this jargon-free guide is a must-have resource that provides the proper tools for evaluating e-learning practices with ease.

Matthew records no fewer than 13 parables of Jesus about the kingdom of heaven. No doubt, the Son of God placed great emphasis on the kingdom, declaring it to be at hand and yet coming. Jesus used parables to reveal previously hidden truths about the kingdom, but for many it remains a mystery. When we turn to the Scriptures, we find perplexing and seemingly contradictory teachings about the kingdom, yet it was the primary focus of Christs teaching.

What is the kingdom of heaven? Is the kingdom here already, or are we to wait for it? Why did Jesus use parables to describe it? Whos in the kingdom and whos not? Why are some cast out of the kingdom? And what can we learn from Jesus stories of mustard seeds, pearls and bridesmaids? The Kingdom According to Jesus explores these questions in a simple and compelling way that encourages readers to seek first the kingdom of God (Matt. 6:33).