Robert E. Kass – författare

The past few years have witnessed dramatic advances in computational methods for Bayesian inference. As a result, Bayesian approaches to solving a wide variety of problems in data analysis and decision-making have become feasible, and there is currently a growth spurt in the application of Bayesian methods. The purpose of this volume is to present several detailed examples of applications of Bayesian thinking, with an emphasis on the scientific or technological context of the problem being solved. The papers collected here were presented and discussed at a Workshop held at Carnegie-Mellon University, September 29 through October 1, 1991. There are five ma­ jor articles, each with two discussion pieces and a reply. These articles were invited by us following a public solicitation of abstracts. The problems they address are diverse, but all bear on policy decision-making. Though not part of our original design for the Workshop, that commonality of theme does emphasize the usefulness of Bayesian meth­ ods in this arena. Along with the invited papers were several additional commentaries of a general nature; the first comment was invited and the remainder grew out of the discussion at the Workshop. In addition there are nine contributed papers, selected from the thirty-four presented at the Workshop, on a variety of applications. This collection of case studies illustrates the ways in which Bayesian methods are being incorporated into statistical practice. The strengths (and limitations) of the approach become apparent through the examples.

Like the first two volumes, this third volume of case studies presents detailed applications of Bayesian statistical analysis, emphasizing the sci­ entific context. The papers were presented and discussed at a workshop at Carnegie Mellon University, October 5-7, 1995. In this volume, which is dedicated to the memory of Morris H. DeGroot, econometric applica­ tions are highlighted. There are six invited papers, each with accompany­ ing invited discussion, and eight contributed papers (which were selected following refereeing). In addition, we include prefatory recollections about Morrie DeGroot by James o. Berger and Richard M. Cyert. INVITED PAPERS In Probing Public Opinion: The State of Valencia Experience, Jose Bernardo, who was a scientific advisor to the President of the State of Valencia, Spain, summarizes procedures that were set up to probe public opinion, and were used as an input to the government's decision making process. At the outset, a sample survey had to be designed. The problem of finding an optimal Bayesian design, based on logarithmic divergence be­ tween probability distributions, involves minimization over 21483 points in the action space. To solve it, simulated annealing was used. The author describes the objective of obtaining the probability that an individual clas­ sified in a certain group will prefer one of several possible alternatives, and his approach using posterior distributions based on reference priors.

The 5th Workshop on Case Studies in Bayesian Statistics was held at the Carnegie Mellon University campus on September 24-25, 1999. As in the past, the workshop featured both invited and contributed case studies. The former were presented and discussed in detail while the latter were presented in poster format. This volume contains the three invited case studies with the accompanying discussion as well as ten contributed pa­ pers selected by a refereeing process. The majority of case studies in the volume come from biomedical research. However, the reader will also find studies in education and public policy, environmental pollution, agricul­ ture, and robotics. INVITED PAPERS The three invited cases studies at the workshop discuss problems in ed­ ucational policy, clinical trials design, and environmental epidemiology, respectively. 1. In School Choice in NY City: A Bayesian Analysis ofan Imperfect Randomized Experiment J. Barnard, C. Frangakis, J. Hill, and D. Rubin report on the analysis of the data from a randomized study conducted to evaluate the New YorkSchool Choice Scholarship Pro­ gram. The focus ofthe paper is on Bayesian methods for addressing the analytic challenges posed by extensive non-compliance among study participants and substantial levels of missing data. 2. In Adaptive Bayesian Designs for Dose-Ranging Drug Trials D. Berry, P. Mueller, A. Grieve, M. Smith, T. Parke, R. Blazek, N.

The 6th Workshop on Case Studies in Bayesian Statistics was held at the Carnegie Mellon University in October, 2001. This volume contains the invited case studies with the accompanying discussion as well as contributed papers selected by a refereeing process.

The 4th Workshop on Case Studies in Bayesian Statistics was held at the Car­ negie Mellon University campus on September 27-28, 1997. As in the past, the workshop featured both invited and contributed case studies. The former were presented and discussed in detail while the latter were presented in poster format. This volume contains the four invited case studies with the accompanying discus­ sion as well as nine contributed papers selected by a refereeing process. While most of the case studies in the volume come from biomedical research the reader will also find studies in environmental science and marketing research. INVITED PAPERS In Modeling Customer Survey Data, Linda A. Clark, William S. Cleveland, Lorraine Denby, and Chuanhai LiD use hierarchical modeling with time series components in for customer value analysis (CVA) data from Lucent Technologies. The data were derived from surveys of customers of the company and its competi­ tors, designed to assess relative performance on a spectrum of issues including product and service quality and pricing. The model provides a full description of the CVA data, with random location and scale effects for survey respondents and longitudinal company effects for each attribute. In addition to assessing the performance of specific companies, the model allows the empirical exploration of the conceptual basis of consumer value analysis. The authors place special em­ phasis on graphical displays for this complex, multivariate set of data and include a wealth of such plots in the paper.

Differential geometry provides an aesthetically appealing and oftenrevealing view of statistical inference. Beginning with anelementary treatment of one-parameter statistical models and endingwith an overview of recent developments, this is the first book toprovide an introduction to the subject that is largely accessibleto readers not already familiar with differential geometry. It alsogives a streamlined entry into the field to readers with richermathematical backgrounds. Much space is devoted to curvedexponential families, which are of interest not only because theymay be studied geometrically but also because they are analyticallyconvenient, so that results may be derived rigorously. In addition,several appendices provide useful mathematical material on basicconcepts in differential geometry. Topics covered include thefollowing:* Basic properties of curved exponential families* Elements of second-order, asymptotic theory* The Fisher-Efron-Amari theory of information loss and recovery* Jeffreys-Rao information-metric Riemannian geometry* Curvature measures of nonlinearity* Geometrically motivated diagnostics for exponential familyregression* Geometrical theory of divergence functions* A classification of and introduction to additional work in thefield

Differential geometry provides an aesthetically appealing and oftenrevealing view of statistical inference. Beginning with anelementary treatment of one-parameter statistical models and endingwith an overview of recent developments, this is the first book toprovide an introduction to the subject that is largely accessibleto readers not already familiar with differential geometry. It alsogives a streamlined entry into the field to readers with richermathematical backgrounds. Much space is devoted to curvedexponential families, which are of interest not only because theymay be studied geometrically but also because they are analyticallyconvenient, so that results may be derived rigorously. In addition,several appendices provide useful mathematical material on basicconcepts in differential geometry. Topics covered include thefollowing: * Basic properties of curved exponential families * Elements of second-order, asymptotic theory * The Fisher-Efron-Amari theory of information loss and recovery * Jeffreys-Rao information-metric Riemannian geometry * Curvature measures of nonlinearity * Geometrically motivated diagnostics for exponential familyregression * Geometrical theory of divergence functions * A classification of and introduction to additional work in thefield

The 4th Workshop on Case Studies in Bayesian Statistics was held at the Car­ negie Mellon University campus on September 27-28, 1997. As in the past, the workshop featured both invited and contributed case studies. The former were presented and discussed in detail while the latter were presented in poster format. This volume contains the four invited case studies with the accompanying discus­ sion as well as nine contributed papers selected by a refereeing process. While most of the case studies in the volume come from biomedical research the reader will also find studies in environmental science and marketing research. INVITED PAPERS In Modeling Customer Survey Data, Linda A. Clark, William S. Cleveland, Lorraine Denby, and Chuanhai LiD use hierarchical modeling with time series components in for customer value analysis (CVA) data from Lucent Technologies. The data were derived from surveys of customers of the company and its competi­ tors, designed to assess relative performance on a spectrum of issues including product and service quality and pricing. The model provides a full description of the CVA data, with random location and scale effects for survey respondents and longitudinal company effects for each attribute. In addition to assessing the performance of specific companies, the model allows the empirical exploration of the conceptual basis of consumer value analysis. The authors place special em­ phasis on graphical displays for this complex, multivariate set of data and include a wealth of such plots in the paper.

The 6th Workshop on Case Studies in Bayesian Statistics was held at the Carnegie Mellon University in October, 2001. This volume contains the invited case studies with the accompanying discussion as well as contributed papers selected by a refereeing process.

Like the first two volumes, this third volume of case studies presents detailed applications of Bayesian statistical analysis, emphasizing the sci­ entific context. The papers were presented and discussed at a workshop at Carnegie Mellon University, October 5-7, 1995. In this volume, which is dedicated to the memory of Morris H. DeGroot, econometric applica­ tions are highlighted. There are six invited papers, each with accompany­ ing invited discussion, and eight contributed papers (which were selected following refereeing). In addition, we include prefatory recollections about Morrie DeGroot by James o. Berger and Richard M. Cyert. INVITED PAPERS In Probing Public Opinion: The State of Valencia Experience, Jose Bernardo, who was a scientific advisor to the President of the State of Valencia, Spain, summarizes procedures that were set up to probe public opinion, and were used as an input to the government''s decision making process. At the outset, a sample survey had to be designed. The problem of finding an optimal Bayesian design, based on logarithmic divergence be­ tween probability distributions, involves minimization over 21483 points in the action space. To solve it, simulated annealing was used. The author describes the objective of obtaining the probability that an individual clas­ sified in a certain group will prefer one of several possible alternatives, and his approach using posterior distributions based on reference priors.

The past few years have witnessed dramatic advances in computational methods for Bayesian inference. As a result, Bayesian approaches to solving a wide variety of problems in data analysis and decision-making have become feasible, and there is currently a growth spurt in the application of Bayesian methods. The purpose of this volume is to present several detailed examples of applications of Bayesian thinking, with an emphasis on the scientific or technological context of the problem being solved. The papers collected here were presented and discussed at a Workshop held at Carnegie-Mellon University, September 29 through October 1, 1991. There are five ma­ jor articles, each with two discussion pieces and a reply. These articles were invited by us following a public solicitation of abstracts. The problems they address are diverse, but all bear on policy decision-making. Though not part of our original design for the Workshop, that commonality of theme does emphasize the usefulness of Bayesian meth­ ods in this arena. Along with the invited papers were several additional commentaries of a general nature; the first comment was invited and the remainder grew out of the discussion at the Workshop. In addition there are nine contributed papers, selected from the thirty-four presented at the Workshop, on a variety of applications. This collection of case studies illustrates the ways in which Bayesian methods are being incorporated into statistical practice. The strengths (and limitations) of the approach become apparent through the examples.

The 5th Workshop on Case Studies in Bayesian Statistics was held at the Carnegie Mellon University campus on September 24-25, 1999. As in the past, the workshop featured both invited and contributed case studies. The former were presented and discussed in detail while the latter were presented in poster format. This volume contains the three invited case studies with the accompanying discussion as well as ten contributed pa­ pers selected by a refereeing process. The majority of case studies in the volume come from biomedical research. However, the reader will also find studies in education and public policy, environmental pollution, agricul­ ture, and robotics. INVITED PAPERS The three invited cases studies at the workshop discuss problems in ed­ ucational policy, clinical trials design, and environmental epidemiology, respectively. 1. In School Choice in NY City: A Bayesian Analysis ofan Imperfect Randomized Experiment J. Barnard, C. Frangakis, J. Hill, and D. Rubin report on the analysis of the data from a randomized study conducted to evaluate the New YorkSchool Choice Scholarship Pro­ gram. The focus ofthe paper is on Bayesian methods for addressing the analytic challenges posed by extensive non-compliance among study participants and substantial levels of missing data. 2. In Adaptive Bayesian Designs for Dose-Ranging Drug Trials D. Berry, P. Mueller, A. Grieve, M. Smith, T. Parke, R. Blazek, N.

Continual improvements in data collection and processing have had a huge impact on brain research, producing data sets that are often large and complicated. By emphasizing a few fundamental principles, and a handful of ubiquitous techniques, Analysis of Neural Data provides a unified treatment of analytical methods that have become essential for contemporary researchers. Throughout the book ideas are illustrated with more than 100 examples drawn from the literature, ranging from electrophysiology, to neuroimaging, to behavior. By demonstrating the commonality among various statistical approaches the authors provide the crucial tools for gaining knowledge from diverse types of data. Aimed at experimentalists with only high-school level mathematics, as well as computationally-oriented neuroscientists who have limited familiarity with statistics, Analysis of Neural Data serves as both a self-contained introduction and a reference work.

Continual improvements in data collection and processing have had a huge impact on brain research, producing data sets that are often large and complicated. By emphasizing a few fundamental principles, and a handful of ubiquitous techniques, Analysis of Neural Data provides a unified treatment of analytical methods that have become essential for contemporary researchers. Throughout the book ideas are illustrated with more than 100 examples drawn from the literature, ranging from electrophysiology, to neuroimaging, to behavior. By demonstrating the commonality among various statistical approaches the authors provide the crucial tools for gaining knowledge from diverse types of data. Aimed at experimentalists with only high-school level mathematics, as well as computationally-oriented neuroscientists who have limited familiarity with statistics, Analysis of Neural Data serves as both a self-contained introduction and a reference work.

In the past decade, major progress has been made in understanding mec- nisms of arrhythmias. This progress stems from much-improved experim- tal, genetic, and computational techniques that have helped to clarify the roles of speci?c proteins in the cardiac cycle, including ion channels, pumps, - changer, adaptor proteins, cell-surface receptors, and contractile proteins. The interactions of these components, and their individual potential as therap- tic targets, have also been studied in detail, via an array of new imaging and sophisticated experimental modalities. The past 10 years have also led to the realization that genetics plays a predominant role in the development of lethal arrhythmias. Many of the topics discussed in this text re?ect very recently undertaken research directions including the genetics of arrhythmias, cell signaling mo- cules as potential therapeutic targets, and traf?cking to the membrane. These new approaches and implementations of anti-arrhythmic therapy derive from many decades of research as outlined in the ?rst chapter by the distinguished professors Michael Rosen (Columbia University) and Michiel Janse (University of Amsterdam).The text covers changes in approaches to arrhythmia therapy over time, in multiple cardiac regions, and over many scales, from gene to protein to cell to tissue to organ.