Robert Naeije – författare

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12 produkter

Pulmonary Circulation
Diseases and Their Treatment, Fourth Edition
AvAndrew J. Peacock,Robert Naeijem. fl.
Häftad, Engelska, 2020
1 814 kr
Skickas inom 10-15 vardagar
Pulmonary Circulation provides physicians with a better understanding of the structure, function and pathophysiology of the pulmonary circulation. It provides comprehensive coverage from diagnosis and clinical evaluation of patients with pulmonary hypertension to imaging techniques, disorders and treatment.This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders. In particular, it provides greater emphasis on the role of the right ventricle in pulmonary vascular disease, updated knowledge on pathobiology and genetics, and includes new material related to imaging and other diagnostic modalities. This edition also reflects new classifications and all the recommendations from the 2013 World Conference on Pulmonary Circulation as well as current guidelines from the European Society of Cardiology and the European Respiratory Society.Thoroughly updated to keep up with the brisk pace of discovery and emerging therapies, the book remains an essential resource by providing a balance between scientific review and clinically relevant guidelines for the busy practicing physician.
Problems of High Altitude Medicine and Biology
AvAlmaz Aldashev,Robert Naeije
Inbunden, Engelska, 2007
2 230 kr
Skickas inom 10-15 vardagar
The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20].
Problems of High Altitude Medicine and Biology
AvAlmaz Aldashev,Robert Naeije
Häftad, Engelska, 2007
2 230 kr
Skickas inom 10-15 vardagar
The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20].
Problems of High Altitude Medicine and Biology
AvRobert Naeije,Almaz Aldashev
E-bok
PDF, Engelska, 2007
2 925 kr
Läs direkt efter köp
The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20].
Right Heart
AvAndrew John Peacock,Robert Naeijem. fl.
E-bok
PDF, Engelska, 2014
2 048 kr
Läs direkt efter köp
The heart and lung are intricately linked. When the heart is affected by disease, the lungs will often show some related pathological or clinical conditions and vice versa. Pulmonary heart disease is by definition a condition when the lungs cause the heart to fail. The left ventricle in combination with the other structures in the “left heart” pumps blood throughout the body. The right ventricle (and structures of the “right heart”) pumps blood to the lungs where it is oxygenated and returned to the left heart for distribution. In normal circumstances, the right heart pumps blood into the lungs without any resistance. The lungs usually have minimal pressure and the right heart easily pumps blood through. However when there is lung disease present, like emphysema, chronic obstructive lung disease (COPD) or pulmonary hypertension- the small blood vessels become very stiff and rigid. The right ventricle is no longer able to push blood into the lungs and eventually fails. This is known as pulmonary heart disease. Pulmonary heart disease is also known as right heart failure or cor pulmonale. The chief cause of right heart failure is the increase in blood pressure in the lungs (pulmonary artery).
Right Heart
AvSean P. Gaine,Robert Naeijem. fl.
Häftad, Engelska, 2016
1 671 kr
Skickas inom 11-20 vardagar
The heart and lung are intricately linked. When the heart is affected by disease, the lungs will often show some related pathological or clinical conditions and vice versa. Pulmonary heart disease is by definition a condition when the lungs cause the heart to fail. The left ventricle in combination with the other structures in the “left heart” pumps blood throughout the body. The right ventricle (and structures of the “right heart”) pumps blood to the lungs where it is oxygenated and returned to the left heart for distribution. In normal circumstances, the right heart pumps blood into the lungs without any resistance. The lungs usually have minimal pressure and the right heart easily pumps blood through. However when there is lung disease present, like emphysema, chronic obstructive lung disease (COPD) or pulmonary hypertension- the small blood vessels become very stiff and rigid. The right ventricle is no longer able to push blood into the lungs and eventually fails. This is known as pulmonary heart disease. Pulmonary heart disease is also known as right heart failure or cor pulmonale. The chief cause of right heart failure is the increase in blood pressure in the lungs (pulmonary artery).
Pulmonary Circulation
Diseases and Their Treatment, Fourth Edition
AvAndrew J. Peacock,Robert Naeijem. fl.
Inbunden, Engelska, 2016
4 198 kr
Skickas inom 5-8 vardagar
Pulmonary Circulation provides physicians with a better understanding of the structure, function and pathophysiology of the pulmonary circulation. It provides comprehensive coverage from diagnosis and clinical evaluation of patients with pulmonary hypertension to imaging techniques, disorders and treatment.This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders. In particular, it provides greater emphasis on the role of the right ventricle in pulmonary vascular disease, updated knowledge on pathobiology and genetics, and includes new material related to imaging and other diagnostic modalities. This edition also reflects new classifications and all the recommendations from the 2013 World Conference on Pulmonary Circulation as well as current guidelines from the European Society of Cardiology and the European Respiratory Society.Thoroughly updated to keep up with the brisk pace of discovery and emerging therapies, the book remains an essential resource by providing a balance between scientific review and clinically relevant guidelines for the busy practicing physician.
Pulmonary Circulation
Diseases and Their Treatment, Fourth Edition
AvLewis J. Rubin,Robert Naeijem. fl.
E-bok
PDF, Engelska, 2016
2 158 kr
Läs direkt efter köp
Pulmonary Circulation provides physicians with a better understanding of the structure, function and pathophysiology of the pulmonary circulation. It provides comprehensive coverage from diagnosis and clinical evaluation of patients with pulmonary hypertension to imaging techniques, disorders and treatment.
This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders. In particular, it provides greater emphasis on the role of the right ventricle in pulmonary vascular disease, updated knowledge on pathobiology and genetics, and includes new material related to imaging and other diagnostic modalities.
This edition also reflects new classifications and all the recommendations from the 2013 World Conference on Pulmonary Circulation as well as current guidelines from the European Society of Cardiology and the European Respiratory Society.
Thoroughly updated to keep up with the brisk pace of discovery and emerging therapies, the book remains an essential resource by providing a balance between scientific review and clinically relevant guidelines for the busy practicing physician.
Pulmonary Circulation
Diseases and Their Treatment, Fourth Edition
AvLewis J. Rubin,Robert Naeijem. fl.
E-bok
Engelska, 2016
2 158 kr
Läs direkt efter köp
Pulmonary Circulation provides physicians with a better understanding of the structure, function and pathophysiology of the pulmonary circulation. It provides comprehensive coverage from diagnosis and clinical evaluation of patients with pulmonary hypertension to imaging techniques, disorders and treatment.
This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders. In particular, it provides greater emphasis on the role of the right ventricle in pulmonary vascular disease, updated knowledge on pathobiology and genetics, and includes new material related to imaging and other diagnostic modalities.
This edition also reflects new classifications and all the recommendations from the 2013 World Conference on Pulmonary Circulation as well as current guidelines from the European Society of Cardiology and the European Respiratory Society.
Thoroughly updated to keep up with the brisk pace of discovery and emerging therapies, the book remains an essential resource by providing a balance between scientific review and clinically relevant guidelines for the busy practicing physician.
Right Heart
AvSean P. Gaine,Robert Naeijem. fl.
Inbunden, Engelska, 2021
1 563 kr
Skickas inom 10-15 vardagar
This heavily revised second edition of this critical book details the structure, function and imaging of the normal right heart both at rest and under the stresses of high altitude and exercise. Extensively revised chapters cover the pathophysiology and pathobiology of right heart dysfunction, both in experimental models and human disease, including congenital heart disease and pulmonary hypertension.The Right Heart provides a concise up-to-date guide on the latest advances in our understanding of role of the right heart in the cardiopulmonary circuit and is an indispensable up-to-date resource for clinicians interested in this topic.
Right Heart
AvAndrew J. Peacock,Robert Naeijem. fl.
E-bok
Engelska, 2021
1 455 kr
Läs direkt efter köp
This heavily revised second edition of this critical book details the structure, function and imaging of the normal right heart both at rest and under the stresses of high altitude and exercise. Extensively revised chapters cover the pathophysiology and pathobiology of right heart dysfunction, both in experimental models and human disease, including congenital heart disease and pulmonary hypertension.
The Right Heart provides a concise up-to-date guide on the latest advances in our understanding of role of the right heart in the cardiopulmonary circuit and is an indispensable up-to-date resource for clinicians interested in this topic.
Right Heart
AvSean P. Gaine,Robert Naeijem. fl.
Häftad, Engelska, 2022
1 119 kr
Skickas inom 10-15 vardagar
This heavily revised second edition of this critical book details the structure, function and imaging of the normal right heart both at rest and under the stresses of high altitude and exercise. Extensively revised chapters cover the pathophysiology and pathobiology of right heart dysfunction, both in experimental models and human disease, including congenital heart disease and pulmonary hypertension.The Right Heart provides a concise up-to-date guide on the latest advances in our understanding of role of the right heart in the cardiopulmonary circuit and is an indispensable up-to-date resource for clinicians interested in this topic.

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Robert Naeije – författare

Pulmonary Circulation

Problems of High Altitude Medicine and Biology

Problems of High Altitude Medicine and Biology

Problems of High Altitude Medicine and Biology

Right Heart

Right Heart

Pulmonary Circulation

Pulmonary Circulation

Pulmonary Circulation

Right Heart

Right Heart

Right Heart

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