S Narasimha Murthy - Böcker

Discussing existing techniques, ongoing research, new approaches, and basic concepts in the treatment of nail diseases, Topical Nail Products and Ungual Drug Delivery summarizes the current knowledge and represents a jumping-off point for creating novel techniques of drug delivery across the nail.A growing area of pharmaceutical research, the search for efficient delivery techniques that can cross the nail barrier has yielded several effective strategies, brought together in this book.Topics Include Nail anatomy, physiology, diseases, and treatmentPermeability of the nail plateTopical nail formulationsApproaches to enhance ungual and trans-ungual drug deliveryIn vitro and in vivo models to evaluate topical nail formulationsNail sampling techniquesBioengineering of the nailTrans-ungual iontophoresisPharmacokinetics of drugs in the nail apparatusOnychopharmacokinetics: proposed model insightPhotodynamic therapy of nail diseasesThe nail as a surrogate for investigating drug use

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders.Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents.Topics include: Theoretical Models for Dermatokinetics of Therapeutic AgentsDrug Delivery Approaches to Modulate Dermatokinetics of DrugsConventional Methods of Cutaneous Drug SamplingCutaneous MicrodialysisSampling Substrates by Skin PermeabilizationSpectroscopic Techniques in Dermatokinetics StudiesRegulatory Perspective of Dermatokinetic Studies

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders.Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents.Topics include: Theoretical Models for Dermatokinetics of Therapeutic AgentsDrug Delivery Approaches to Modulate Dermatokinetics of DrugsConventional Methods of Cutaneous Drug SamplingCutaneous MicrodialysisSampling Substrates by Skin PermeabilizationSpectroscopic Techniques in Dermatokinetics StudiesRegulatory Perspective of Dermatokinetic Studies

Discussing existing techniques, ongoing research, new approaches, and basic concepts in the treatment of nail diseases, Topical Nail Products and Ungual Drug Delivery summarizes the current knowledge and represents a jumping-off point for creating novel techniques of drug delivery across the nail.A growing area of pharmaceutical research, the search for efficient delivery techniques that can cross the nail barrier has yielded several effective strategies, brought together in this book.Topics Include Nail anatomy, physiology, diseases, and treatmentPermeability of the nail plateTopical nail formulationsApproaches to enhance ungual and trans-ungual drug deliveryIn vitro and in vivo models to evaluate topical nail formulationsNail sampling techniquesBioengineering of the nailTrans-ungual iontophoresisPharmacokinetics of drugs in the nail apparatusOnychopharmacokinetics: proposed model insightPhotodynamic therapy of nail diseasesThe nail as a surrogate for investigating drug use