Seth Kwabena Amponsah – författare

Understanding Renal Biochemistry: Insights from Nephrotic Syndrome to Systemic Renal Dynamics provides a comprehensive exploration of nephrotic syndrome and related renal disorders. Tailored for academicians, young researchers, and graduate/postgraduate students worldwide in fields such as renal research, chemical pathology, medical biochemistry, pharmacology, laboratory science, and pathology, this book offers cutting-edge insights into novel diagnostic approaches, underlying pathophysiology, and effective management strategies. Enriched with real-world case studies, it bridges theoretical knowledge with practical application, empowering readers to advance their understanding and make informed decisions in the diagnosis and treatment of renal diseases. The book provides a well-structured exploration of renal biochemistry and related disciplines, guiding readers through foundational concepts to advanced research and future directions in nephrology. Authored by experts, chapters cover topics such as renal biomarkers, diagnostic precision, therapeutic interventions, and management strategies, with case studies illustrating real-world applications. Each chapter begins with a clear outline, incorporates strategic case studies, and concludes with comprehensive summaries, ensuring readers can easily grasp core concepts and benefit from practical insights, enhancing their learning experience and retention of knowledge. With each chapter supplemented by figures, tables, and case studies, this book provides a comprehensive resource for anyone seeking to deepen their understanding of renal pathophysiology and its clinical management. For scientists and researchers, the book fills a crucial gap by providing a comprehensive resource on renal pathophysiology, covering both glomerular and tubular dysfunctions, thus offering valuable insights and the latest advancements in nephrology research. For clinicians, it serves as an essential reference, offering extensive information on relevant biochemical markers for disease diagnosis, providing practical guidance to enhance clinical practice and improve patient outcomes.Provides comprehensive coverage of nephrotic syndrome and related renal disorders, offering insights into molecular mechanisms, diagnostic advancements, and tailored therapeutic strategies, all in one resourceExplores cutting-edge insights into novel biochemical markers and emerging trends in renal pathology diagnosis, ensuring readers stay at the forefront of nephrology researchApplies practical application through real-world case studies, bridging theoretical understanding with clinical practice and empowering readers to make informed decisions in the diagnosis and treatment of renal diseases

This volume provides an overview of the biochemical basis of metabolic diseases and molecular basis of chemical pathologies. Metabolic disorders occur when metabolic processes in the body are disrupted. They contribute a significant burden to human health globally. They can be congenital or acquired, for example, diabetes mellitus, obesity, metabolic syndrome, osteoporosis, osteopenia, mild-moderate hypovitaminosis D, erectile dysfunction, dyslipidemia, and thyroiditis. Metabolic disorders have gained significant importance due to the exponential increase in obesity worldwide. Early diagnosis of metabolic disorders is important in order to employ lifestyle and risk factor modification.Features:An overview of the biochemical basis of metabolic diseases and molecular basis of chemical pathologiesDescribes recent trends in diagnosis of metabolic disordersDiscusses management and treatment of metabolic diseasesAllows quick identification and retrieval of material by researchers learning the efficacy, associated dosage and toxicity of each of the classes of compoundsSuitable globally for graduate and postgraduate students studying metabolic diseases

This volume provides an overview of the biochemical basis of metabolic diseases and molecular basis of chemical pathologies. Metabolic disorders occur when metabolic processes in the body are disrupted. They contribute a significant burden to human health globally. They can be congenital or acquired, for example, diabetes mellitus, obesity, metabolic syndrome, osteoporosis, osteopenia, mild-moderate hypovitaminosis D, erectile dysfunction, dyslipidemia, and thyroiditis. Metabolic disorders have gained significant importance due to the exponential increase in obesity worldwide. Early diagnosis of metabolic disorders is important in order to employ lifestyle and risk factor modification.Features:An overview of the biochemical basis of metabolic diseases and molecular basis of chemical pathologiesDescribes recent trends in diagnosis of metabolic disordersDiscusses management and treatment of metabolic diseasesAllows quick identification and retrieval of material by researchers learning the efficacy, associated dosage and toxicity of each of the classes of compoundsSuitable globally for graduate and postgraduate students studying metabolic diseases

To arrive at the most appropriate decision regarding patient management, an essential step for medical practitioners is to determine a correct and accurate diagnosis of the patient’s condition. In recent years there have been significant technological efforts in chemistry, biochemistry, laboratory science, and biotechnology toward improving disease diagnosis and management in patients. Further, drug developers have utilized some of these novel diagnostic methods during preclinical and clinical trials that have led to creating efficiencies in their development processes. This book provides an overview of diagnostic procedures that aid in precision medicine and the drug development process.Presents innovative methodologies for diagnostic testing that will be beneficial to biomedical science researchers and health professionalsDiscusses recent significant technological advancement toward improving disease diagnosisDescribes recent developments in spectroscopic and chromatographic methods that will be of interest to pharma companies and scientists in chemistry, biochemistry and pharmacologyGives an overview of the integration of artificial intelligence in digital health that will be beneficial to biotechnologists, bioengineers, health professionals and people in regulatory agenciesIs suitable globally for graduate and postgraduate students studying laboratory medicine

Substance abuse and addiction is the use of illegal drugs, prescription or over-the-counter drugs or household substances in a way that is detrimental to self, society or both. This volume discusses social, psychological, cultural, biological, and medical perspectives of substance abuse and addiction in special populations; with appropriate case study examples. It further captures the various abused substances, novel assay techniques, laws governing use of these substances and management strategies. It includes a compendium of information on recent trends in substance abuse and addiction in special populations like adolescents, pregnant women, athletes, health professionals, among others.

Substance abuse and addiction is the use of illegal drugs, prescription or over-the-counter drugs or household substances in a way that is detrimental to self, society or both. This volume discusses social, psychological, cultural, biological, and medical perspectives of substance abuse and addiction in special populations; with appropriate case study examples. It further captures the various abused substances, novel assay techniques, laws governing use of these substances and management strategies. It includes a compendium of information on recent trends in substance abuse and addiction in special populations like adolescents, pregnant women, athletes, health professionals, among others.

Comprehensive yet succinct insight into the prevention, diagnosis, and treatment of infectious diseases including COVID-19, mpox, Ebola, and Lyme diseaseRising Contagious Diseases provides basic information about preventing and treating threatening infectious diseases from viral, bacterial, and parasitic sources, including 28 emerging or recurring diseases like COVID-19, mpox, Ebola, bird and swine flu, malaria, Legionnaires', and others. The text highlights molecular surveillance and epidemiology (including zoonotic pathogens or their variants), innovative strategies for pathogen detection, drug and vaccine development, appropriate preventive measures, cost-effective diagnostic procedures (assays), and effective therapeutic strategies.The text is unique due to its broad coverage of today's infectious diseases, covering several which are not similarly addressed elsewhere, with detailed insight from experts around the world.Composed of 30 chapters of fundamental facts alongside practical and clinical data, Rising Contagious Diseases covers sample topics such as: Re-emergence of certain diseases in recent decades due to dynamic host-pathogen interactions, anthropogenic selection, and climate changeHow real-time epidemiological surveillance can improve detection of infectious disease outbreaks or new infections of public health importanceUp-to-date insight on transmission dynamics, epidemiology, clinical manifestation, advances in diagnostics, and management of covered diseasesEffects of disease outbreaks on the world at large, such as through high morbidity and mortality rates and rising healthcare costsWith detailed insight on the prevention, diagnosis, and treatment of infectious diseases, Rising Contagious Diseases is an essential reference for health care professionals, academics in the field of microbiology, immunology, infectious diseases, pathology, pharmacology and public health, and undergraduates and postgraduates in related disciplines.

An up-to-date exploration of techniques for effectively treating patients from special populations In Basics and Clinical Applications of Drug Disposition in Special Populations, a team of distinguished researchers delivers a timely and authoritative discussion of how to predict drug disposition in special populations, including people with obesity, pediatric patients, geriatric patients, and patients with renal and hepatic impairment. The authors use pharmacokinetic models to account for variabilities between populations and to better predict drug disposition. The book offers a collection of 15 chapters written by recognized experts in their respective fields. They cover topics ranging from the optimization of drug dosing regimens in specialized populations to model-based approaches in drug treatment among pediatrics. Readers will also find: A thorough introduction to considerations and regulatory affairs for clinical research in special populationsComprehensive explorations of drug disposition in geriatrics, patients with hepatic insufficiency, and patients with renal insufficiency Practical discussions of model-based pharmacokinetic approachesComplete treatments of artificial intelligence in drug developmentPerfect for practicing pharmacologists, pharmacists, and clinical chemists, Basics and Clinical Applications of Drug Disposition in Special Populations will also benefit medical professionals who provide medical and pharmaceutical care to special populations.

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring.  This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome.  The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies.The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges