Shraddha Manish Gupta – författare

Alzheimer’s disease continues to present one of the foremost scientific and clinical challenges in contemporary neuroscience. Despite significant advances in molecular biology and neuroimaging, its complex etiology and progressive course remain only partially understood, and truly effective disease-modifying therapies remain elusive.This scholarly volume offers a comprehensive and integrative examination of Alzheimer’s disease, combining cutting-edge research with clinical perspectives. Alzheimer’s Disease: Diagnosis, Molecular Targets, and Therapeutic Modalities assembles contributions from leading experts, providing in-depth analysis across a wide range of critical topics:Innovative diagnostic biomarkers for early detection, prognosis, and therapeutic monitoringExploration of molecular targets, including secretases, SIRT2, RAGE, calpain, caspases, NMDA receptors, and others implicated in AD pathophysiologyEmerging therapeutic interventions encompassing enzyme inhibitors, immunotherapeutic strategies, metal chelation, neurotrophic modulation, and aggregation inhibitorsAdvances in translational research featuring nanotechnology-based delivery systems and bioactive natural compoundsEvidence-based lifestyle interventions integrating nutrition and physical activity in disease managementSpanning 21 rigorously curated chapters, this volume offers a multidisciplinary framework that bridges fundamental research, translational applications, and clinical relevance. It is an essential reference for neuroscientists, clinical researchers, pharmacologists, graduate students, and healthcare professionals engaged in the investigation and management of neurodegenerative disorders.By synthesizing current scientific knowledge with emerging therapeutic strategies, this volume aims to advance understanding and stimulate further research toward effective interventions for Alzheimer’s disease.

Alzheimer's disease continues to present one of the foremost scientific and clinical challenges in contemporary neuroscience. Despite significant advances in molecular biology and neuroimaging, its complex etiology and progressive course remain only partially understood, and truly effective disease-modifying therapies remain elusive.This scholarly volume offers a comprehensive and integrative examination of Alzheimer's disease, combining cutting-edge research with clinical perspectives. Alzheimer's Disease: Diagnosis, Molecular Targets, and Therapeutic Modalities assembles contributions from leading experts, providing in-depth analysis across a wide range of critical topics: Innovative diagnostic biomarkers for early detection, prognosis, and therapeutic monitoring Exploration of molecular targets, including secretases, SIRT2, RAGE, calpain, caspases, NMDA receptors, and others implicated in AD pathophysiology Emerging therapeutic interventions encompassing enzyme inhibitors, immunotherapeutic strategies, metal chelation, neurotrophic modulation, and aggregation inhibitors Advances in translational research featuring nanotechnology-based delivery systems and bioactive natural compounds Evidence-based lifestyle interventions integrating nutrition and physical activity in disease management Spanning 21 rigorously curated chapters, this volume offers a multidisciplinary framework that bridges fundamental research, translational applications, and clinical relevance. It is an essential reference for neuroscientists, clinical researchers, pharmacologists, graduate students, and healthcare professionals engaged in the investigation and management of neurodegenerative disorders.By synthesizing current scientific knowledge with emerging therapeutic strategies, this volume aims to advance understanding and stimulate further research toward effective interventions for Alzheimer's disease.

In the era of precision medicine, the demand for smart and targeted drug delivery technologies is greater than ever. Redox-responsive delivery systems represent a cutting-edge approach that exploits the unique oxidative and reductive environments of diseased tissues to achieve site-specific therapeutic action.This comprehensive volume brings together foundational knowledge, recent innovations, and application-specific insights into redox-sensitive systems used for drug, gene and vaccine delivery. The book covers a wide range of carriers-including polymersomes, liposomes, nanoparticles, micelles, prodrugs and dendrimers-highlighting their utility across various therapeutic landscapes, including cancer, neurodegenerative diseases, metabolic disorders, infectious diseases and gene editing platforms like CRISPR-Cas9.Key Features: Explores the principles and design of redox-responsive materials Covers disease-specific applications, including Alzheimer's, Parkinson's, diabetes and antimicrobial resistance Discusses innovative delivery systems for siRNA and genome editing Addresses industrial translation, scale-up and commercialization challenges Authored by leading experts in pharmaceutics, nanomedicine and biomedical engineering Ideal for pharmaceutical scientists, nanotechnologists, biomedical researchers and healthcare innovators, this book serves as a definitive guide to one of the most promising frontiers in drug delivery science.Harness redox biology to revolutionize how therapeutics are delivered-safely, smartly and effectively.

In the era of precision medicine, the demand for smart and targeted drug delivery technologies is greater than ever. Redox-responsive delivery systems represent a cutting-edge approach that exploits the unique oxidative and reductive environments of diseased tissues to achieve site-specific therapeutic action.This comprehensive volume brings together foundational knowledge, recent innovations, and application-specific insights into redox-sensitive systems used for drug, gene and vaccine delivery. The book covers a wide range of carriers-including polymersomes, liposomes, nanoparticles, micelles, prodrugs and dendrimers-highlighting their utility across various therapeutic landscapes, including cancer, neurodegenerative diseases, metabolic disorders, infectious diseases and gene editing platforms like CRISPR-Cas9.Key Features: Explores the principles and design of redox-responsive materials Covers disease-specific applications, including Alzheimer's, Parkinson's, diabetes and antimicrobial resistance Discusses innovative delivery systems for siRNA and genome editing Addresses industrial translation, scale-up and commercialization challenges Authored by leading experts in pharmaceutics, nanomedicine and biomedical engineering Ideal for pharmaceutical scientists, nanotechnologists, biomedical researchers and healthcare innovators, this book serves as a definitive guide to one of the most promising frontiers in drug delivery science.Harness redox biology to revolutionize how therapeutics are delivered-safely, smartly and effectively.

Alzheimer's disease continues to present one of the foremost scientific and clinical challenges in contemporary neuroscience. Despite significant advances in molecular biology and neuroimaging, its complex etiology and progressive course remain only partially understood, and truly effective disease-modifying therapies remain elusive.This scholarly volume offers a comprehensive and integrative examination of Alzheimer's disease, combining cutting-edge research with clinical perspectives. Alzheimer's Disease: Diagnosis, Molecular Targets, and Therapeutic Modalities assembles contributions from leading experts, providing in-depth analysis across a wide range of critical topics: Innovative diagnostic biomarkers for early detection, prognosis, and therapeutic monitoring Exploration of molecular targets, including secretases, SIRT2, RAGE, calpain, caspases, NMDA receptors, and others implicated in AD pathophysiology Emerging therapeutic interventions encompassing enzyme inhibitors, immunotherapeutic strategies, metal chelation, neurotrophic modulation, and aggregation inhibitors Advances in translational research featuring nanotechnology-based delivery systems and bioactive natural compounds Evidence-based lifestyle interventions integrating nutrition and physical activity in disease management Spanning 21 rigorously curated chapters, this volume offers a multidisciplinary framework that bridges fundamental research, translational applications, and clinical relevance. It is an essential reference for neuroscientists, clinical researchers, pharmacologists, graduate students, and healthcare professionals engaged in the investigation and management of neurodegenerative disorders.By synthesizing current scientific knowledge with emerging therapeutic strategies, this volume aims to advance understanding and stimulate further research toward effective interventions for Alzheimer's disease.

Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, represent a rapidly escalating global health burden with limited disease-modifying therapies. Advances in medicinal chemistry have highlighted nitrogen-containing heterocycles as powerful scaffolds in the search for effective neuroprotective agents. Their structural diversity, target specificity, and favorable pharmacological profiles position them at the forefront of next-generation drug discovery.Nitrogen Heterocycles in Neurodegenerative Disorders: Chemistry and Therapeutic Potential delivers a comprehensive and research-driven exploration of the chemistry, biological relevance, and translational promise of nitrogen-based heterocyclic compounds. Distinct in its integrative approach, the book bridges synthetic chemistry, molecular pharmacology, and clinical perspectives. It not only discusses established heterocyclic frameworks but also critically evaluates emerging scaffolds, structure-activity relationships, and challenges in blood-brain barrier penetration-offering readers both foundational knowledge and forward-looking insights.Key Features: Detailed overview of neurodegenerative disease pathophysiology Exploration of molecular targets and signaling pathways Design, synthesis, and SAR studies of key nitrogen heterocycles Pharmacokinetic and pharmacodynamic considerations for CNS drugs Future perspectives on heterocycle-based neurotherapeutics This volume serves as an essential reference for medicinal chemists, pharmaceutical scientists, neuroscientists, clinicians, and postgraduate researchers seeking a deeper understanding of heterocyclic strategies in combating neurodegeneration.

Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, represent a rapidly escalating global health burden with limited disease-modifying therapies. Advances in medicinal chemistry have highlighted nitrogen-containing heterocycles as powerful scaffolds in the search for effective neuroprotective agents. Their structural diversity, target specificity, and favorable pharmacological profiles position them at the forefront of next-generation drug discovery.Nitrogen Heterocycles in Neurodegenerative Disorders: Chemistry and Therapeutic Potential delivers a comprehensive and research-driven exploration of the chemistry, biological relevance, and translational promise of nitrogen-based heterocyclic compounds. Distinct in its integrative approach, the book bridges synthetic chemistry, molecular pharmacology, and clinical perspectives. It not only discusses established heterocyclic frameworks but also critically evaluates emerging scaffolds, structure-activity relationships, and challenges in blood-brain barrier penetration-offering readers both foundational knowledge and forward-looking insights.Key Features: Detailed overview of neurodegenerative disease pathophysiology Exploration of molecular targets and signaling pathways Design, synthesis, and SAR studies of key nitrogen heterocycles Pharmacokinetic and pharmacodynamic considerations for CNS drugs Future perspectives on heterocycle-based neurotherapeutics This volume serves as an essential reference for medicinal chemists, pharmaceutical scientists, neuroscientists, clinicians, and postgraduate researchers seeking a deeper understanding of heterocyclic strategies in combating neurodegeneration.

In the era of precision medicine, the demand for smart and targeted drug delivery technologies is greater than ever. Redox-responsive delivery systems represent a cutting-edge approach that exploits the unique oxidative and reductive environments of diseased tissues to achieve site-specific therapeutic action.This comprehensive volume brings together foundational knowledge, recent innovations, and application-specific insights into redox-sensitive systems used for drug, gene and vaccine delivery. The book covers a wide range of carriers—including polymersomes, liposomes, nanoparticles, micelles, prodrugs and dendrimers—highlighting their utility across various therapeutic landscapes, including cancer, neurodegenerative diseases, metabolic disorders, infectious diseases and gene editing platforms like CRISPR-Cas9.Key Features:Explores the principles and design of redox-responsive materialsCovers disease-specific applications, including Alzheimer’s, Parkinson’s, diabetes and antimicrobial resistanceDiscusses innovative delivery systems for siRNA and genome editingAddresses industrial translation, scale-up and commercialization challengesAuthored by leading experts in pharmaceutics, nanomedicine and biomedical engineeringIdeal for pharmaceutical scientists, nanotechnologists, biomedical researchers and healthcare innovators, this book serves as a definitive guide to one of the most promising frontiers in drug delivery science.Harness redox biology to revolutionize how therapeutics are delivered—safely, smartly and effectively.