Kamal Shah - Böcker

Recent Advancement in ProdrugsDrugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations.Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews prodrugs in cancer nanomedicine, its therapy and treatment Elucidates mathematical models to study the kinetics of prodrugsThis book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.

Neurodegenerative diseases affect millions of people worldwide and are a group of several diseases with distinct pathology, physiology, prevention, and treatment strategies. Recently, natural products especially derived from medicinal plants are gaining momentum to manage neurodegenerative disease safely and effectively. Therefore, there is an urgent need to provide a ready roadmap for scientifically validated value-added nutraceutical and pharmaceutical safe and effective product for the management of various neurodegenerative diseasesNatural Scaffolds for Prevention and Treatment of Neurodegenerative Disorders will provide compiled information stating several identified neurodegenerative diseases including pathology and physiology. From vast literature on natural products, such asscientifically validated plant bioactives, traditional approaches to combat or prevent neurodegenerative conditions are also included along with molecular mechanisms. The book will further specify:Single window complied information on various neurodegenerative diseases.Possible projection of bioactivity from natural resources to each category of neurodegenerative diseases.Ready-to-use reference material to develop several value-added products or proceed to the next level.The book will be very useful for nutraceutical research groups, education institutions, and industries focusing on developing value-added solutions for the management of several neurodegenerative diseases.

Food microbiology is the science that comprises the details about various microorganisms associated with food in beneficial and harmful aspects. Spoilage of food by microorganisms has become a problem for many people around the world as foods act as a nutrient source for microorganisms. The past ten years have seen a shift in the field of epidemiology of microbial illness caused by food. This shift has been attributed to the emergence of newly identified foodborne pathogens as well as to changes in lifestyle factors, such as convenience foods, more adventurous eating, and less time spent preparing meals. It is critical to control foodborne illnesses at every stage of the supply chain, from food manufacturing and preparation to customer delivery. Foodborne hazard control can be aided by both established technology and novel strategies like Hazard Analysis Critical Control Point (HACCP) programs and radiation hazard analysis. However, rising microbiological food safety concerns will remain a major public health concern because of microorganisms and the continual evolution of products, processes, and food handling methods.KEY FEATURESTo understand the basic information and applied aspects of food microbiology.To provide comprehensive knowledge about food spoilage and foodborne pathogens.To update readers with modernized food preservation methods and the biotechnology involved, along with quality control standards.To describe the latest research ongoing in food fermentation, food safety standards, and emerging issues in the field.This book is designed for students and research scientists working in the field of food safety and food microbiology, including graduate and postgraduate students, scholars, academicians, scientists, and professionals in food and dairy technology, life sciences, agriculture, pharmaceutical sciences, and biomedical sciences.

Alzheimer’s disease continues to present one of the foremost scientific and clinical challenges in contemporary neuroscience. Despite significant advances in molecular biology and neuroimaging, its complex etiology and progressive course remain only partially understood, and truly effective disease-modifying therapies remain elusive.This scholarly volume offers a comprehensive and integrative examination of Alzheimer’s disease, combining cutting-edge research with clinical perspectives. Alzheimer’s Disease: Diagnosis, Molecular Targets, and Therapeutic Modalities assembles contributions from leading experts, providing in-depth analysis across a wide range of critical topics:Innovative diagnostic biomarkers for early detection, prognosis, and therapeutic monitoringExploration of molecular targets, including secretases, SIRT2, RAGE, calpain, caspases, NMDA receptors, and others implicated in AD pathophysiologyEmerging therapeutic interventions encompassing enzyme inhibitors, immunotherapeutic strategies, metal chelation, neurotrophic modulation, and aggregation inhibitorsAdvances in translational research featuring nanotechnology-based delivery systems and bioactive natural compoundsEvidence-based lifestyle interventions integrating nutrition and physical activity in disease managementSpanning 21 rigorously curated chapters, this volume offers a multidisciplinary framework that bridges fundamental research, translational applications, and clinical relevance. It is an essential reference for neuroscientists, clinical researchers, pharmacologists, graduate students, and healthcare professionals engaged in the investigation and management of neurodegenerative disorders.By synthesizing current scientific knowledge with emerging therapeutic strategies, this volume aims to advance understanding and stimulate further research toward effective interventions for Alzheimer’s disease.

Mangrove ecosystems represent one of nature’s most dynamic interfaces between terrestrial and marine environments. Over the past few decades, these resilient plants have drawn increasing scientific attention for their remarkable phytochemical diversity and pharmacological potential.Phytochemical and Pharmacological Implications of Mangroves presents a comprehensive exploration of the chemical and therapeutic attributes of mangroves and their associated microbiota. This volume integrates fundamental and applied research to highlight the significance of mangrove-derived natural products in drug discovery and biomedical innovation.Key Features:· Part I: Introduction- Provides an overview of current trends and future prospects in mangrove research, with emphasis on ecological relevance and emerging biotechnological applications.· Part II: Phytochemical Implications of Mangroves- Examines the occurrence, distribution, and biological significance of diverse secondary metabolites, including flavonoids, terpenoids, steroids, alkaloids, carotenoids, lignan glycosides, anthraquinones, and fatty acids. A dedicated chapter explores mangrove-associated endophytes as potent producers of novel bioactive compounds.· Part III: Pharmacological Implications of Mangroves- Discusses the therapeutic potential of mangrove-derived metabolites in the prevention and management of major diseases such as cancer, neurodegenerative disorders, cardiovascular ailments, inflammatory bowel disease, diabetes, liver dysfunction, ophthalmic diseases, atopic dermatitis, and microbial infections.Written and reviewed by experts in phytochemistry, pharmacology, and marine biotechnology, this book provides a detailed account of how mangrove biodiversity can be harnessed for sustainable healthcare solutions.Phytochemical and Pharmacological Implications of Mangroves serves as an invaluable reference for researchers, academicians, and professionals in the fields of natural product chemistry, pharmacognosy, marine biology, and environmental sciences.

Moringa oleifera is a small plant found around the globe. It is known as a miracle tree, due to its diverse medicinal uses. The various part of the plant like root, stem, leaf, flower, fruit and seed have some nutritive values. This plant is rich in phenolic contents, flavonoids, carotenoids, proteins, vitamins, fatty acids, various micro or macro nutrients.This book highlights the nutritional, pharmaceutical and medicinal values of Moringa oleifera and its utilization as nutraceuticals and functional foods. It covers the current importance of Moringa oleifera nutritional properties, pharmacological importance, and biological activities. Special chapters on Moringa oleifera harvesting, handling, and storage practices as well as traditional uses of its various parts.This book reports the importance of Moringa in aagriculture, horticulture, functional food, cosmetics, clinical nutrition, pharmaceuticals, bacterial fermentation products, biosafety, industrial applications, toxicology, and side effects if any are also discussed.The book has covered the :· Phytochemistry of Moringa oleifera.· Active constituents and their nutritional effects of Moringa oleifera.· Detail applications of Moringa oleifera phytochemicals, products , and extracts.· Importance of Moringa oleifera in Agriculture, horticulture, functional food.Applications of Moringa oleifera in cosmetics,clinical nutrition, and pharmaceuticals

In the era of precision medicine, the demand for smart and targeted drug delivery technologies is greater than ever. Redox-responsive delivery systems represent a cutting-edge approach that exploits the unique oxidative and reductive environments of diseased tissues to achieve site-specific therapeutic action.This comprehensive volume brings together foundational knowledge, recent innovations, and application-specific insights into redox-sensitive systems used for drug, gene and vaccine delivery. The book covers a wide range of carriers—including polymersomes, liposomes, nanoparticles, micelles, prodrugs and dendrimers—highlighting their utility across various therapeutic landscapes, including cancer, neurodegenerative diseases, metabolic disorders, infectious diseases and gene editing platforms like CRISPR-Cas9.Key Features:Explores the principles and design of redox-responsive materialsCovers disease-specific applications, including Alzheimer’s, Parkinson’s, diabetes and antimicrobial resistanceDiscusses innovative delivery systems for siRNA and genome editingAddresses industrial translation, scale-up and commercialization challengesAuthored by leading experts in pharmaceutics, nanomedicine and biomedical engineeringIdeal for pharmaceutical scientists, nanotechnologists, biomedical researchers and healthcare innovators, this book serves as a definitive guide to one of the most promising frontiers in drug delivery science.Harness redox biology to revolutionize how therapeutics are delivered—safely, smartly and effectively.

Neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, represent a rapidly escalating global health burden with limited disease-modifying therapies. Advances in medicinal chemistry have highlighted nitrogen-containing heterocycles as powerful scaffolds in the search for effective neuroprotective agents. Their structural diversity, target specificity, and favorable pharmacological profiles position them at the forefront of next-generation drug discovery.Nitrogen Heterocycles in Neurodegenerative Disorders: Chemistry and Therapeutic Potential deliver a comprehensive and research-driven exploration of the chemistry, biological relevance, and translational promise of nitrogen-based heterocyclic compounds. Distinct in its integrative approach, the book bridges synthetic chemistry, molecular pharmacology, and clinical perspectives. It not only discusses established heterocyclic frameworks but also critically evaluates emerging scaffolds, structure–activity relationships, and challenges in blood–brain barrier penetration—offering readers both foundational knowledge and forward-looking insights.Key Features:✔ Detailed overview of neurodegenerative disease pathophysiology✔ Exploration of molecular targets and signaling pathways✔ Design, synthesis, and SAR studies of key nitrogen heterocycles✔ Pharmacokinetic and pharmacodynamic considerations for CNS drugs✔ Future perspectives on heterocycle-based neurotherapeuticsThis volume serves as an essential reference for medicinal chemists, pharmaceutical scientists, neuroscientists, clinicians, and postgraduate researchers seeking a deeper understanding of heterocyclic strategies in combating neurodegeneration.

Because of increasing antibiotic resistance, stronger antibiotics are reserved for serious active infection, paving the way for a greater use of herbal antibiotics. This book helps dentists in implementing safe and effective natural medicine therapies to complement the current practice guidelines.Oral diseases continue to be a major health problem world-wide. Oral health is integral to general well-being and relates to the quality-of-life that extends beyond the functions of the craniofacial complex. The standard Western medicine has had only limited success in the prevention of periodontal disease and in the treatment of a variety of oral diseases.The dentist needs to be more informed regarding the use, safety and effectiveness of the various traditional medicines and over-the-counter products.Herbal extracts have been used in dentistry for reducing inflammation, as antimicrobial plaque agents, for preventing release of histamine and as antiseptics, antioxidants, antimicrobials, antifungals, antibacterials, antivirals and analgesics. They also aid in healing and are effective in controlling microbial plaque in gingivitis and periodontitis and thereby improving immunity.The 26 chapters in this unique book explore all the measures to utilize the natural oral care obtained from plants, animals and mineral drugs for dental care.

Medicinal plants contain a variety of bioactive compounds, (also referred to as phytochemicals). in the leaves, stems, flowers and fruits. This book covers these bioactive compounds, their available sources, how the bioactive molecules are isolated from the plants, the biochemistry, structural composition and potential biological activities. Also discussed are the pharmacological aspects of medicinal plants, phytochemistry and biological activities of different natural products, ethnobotany and medicinal properties, as well as a novel dietary approach for various disease management and therapeutic potential. The importance of phytopharmaceutical of plants and potential applications in the food and pharma industries is highlighted.

Highly comprehensive and detailed text on best possible sustainable approaches associated with the development, design, and origination of pharmaceuticals Sustainable Approaches in Pharmaceutical Sciences enables readers to understand the best possible green approaches associated with the development, design, and origination of pharmaceuticals, including resources that may minimize the adverse effects associated with synthesis, isolation, and extraction. Sustainable Approaches in Pharmaceutical Sciences covers a myriad of current topics, including mechanochemical improvements for API synthesis, as well as the role of artificial intelligence (AI) in the development and discovery of pharmaceuticals, along with recent developments in hydrogels which respond to triggered factors during topical drug delivery. Authored by experienced scientists from institutions across the world, other sample topics covered in Sustainable Approaches in Pharmaceutical Sciences include: Green technologies and benefits associated with them, white biotechnology, green chemistry, and eco-friendly approaches for designing active pharmaceutical ingredientsImpact of sustainable approaches in pharmaceutical industries regarding use of solvents, nanoparticles formulations, and antimicrobial bandagesMicro-extractive methods capable of generating high recovery values of the analytes and associated techniques, such as dispersive liquid-liquid microextractionBenefits of the exploration of sustainable chemistry on a commercial scale, particularly in relation to bioresources, chemical manufacturing, and organic transformationDiscussing both the foundational science and practicality of different approaches regarding human and environmental health, Sustainable Approaches in Pharmaceutical Sciences is an essential resource for scientists, medical professionals, and industrial professionals working in the fields of sustainable technology and synthesis in pharmaceutical sciences, along with advanced level students.

Pharmacological Studies in Natural Oral Care Edited by a natural product scientist, clinician, pharmacologist and a dental surgeon, the book helps oral care specialists to implement safe and effective natural medicine therapies to complement current practice guidelines. With oral care specialists focusing their attention on the interdisciplinary connections between oral health, heart health, gastrointestinal health, etc., and with increasing antibiotic resistance and stronger antibiotics now reserved for serious active infection, the importance of herbal antibiotics is increasing exponentially. This book helps to implement safe and effective natural medicine therapies to complement the current practice guidelines. Pharmacological Studies in Natural Oral Care is a comprehensive compilation and explores all the measures to utilize the natural oral care obtained from plants, animals, and mineral drugs for dental care. Herbal extracts are used in dentistry for reducing inflammation, as antimicrobial plaque agents, for preventing the release of histamine, and as antiseptics, antioxidants, antimicrobials, antifungals, antibacterials, antivirals and analgesics. They also aid in healing and are effective in controlling microbial plaque in gingivitis and periodontitis, thereby improving immunity. Audience This important new book will be invaluable to medicinal chemists, pharmacologists, natural product formulation scientists, dental surgeons, orthodontists, periodontists, endodontists, prosthodontists, maxillofacial surgeons, dentists, oral hygienists, as well as a reference for the pharmaceutical/ herbal industries and dental libraries.

This book presents articles from the International Conference on Blockchain Technology (IC-BCT) 2019, held in Mumbai, India, and highlights recent advances in the field.