Simon C. Gandevia – författare

This volume describes the current state of our knowledge on the neurobiology of muscle fatigue, with consideration also given to selected integrative cardiorespiratory mechanisms. Our charge to the authors of the various chapters was twofold: to provide a systematic review of the topic that could serve as a balanced reference text for practicing health-care professionals, teaching faculty, and pre-and postdoctoral trainees in the biomedi­ cal sciences; and to stimulate further experimental and theoretical work on neurobiology. Key issues are addressed in nine interrelated areas: fatigue of single muscle fibers, fatigue at the neuromuscular junction, fatigue of single motor units, metabolic fatigue studied with nuclear magnetic resonance, fatigue of the segmental motor system, fatigue involving suprasegmental mechanisms, the task dependency of fatigue mechanisms, integrative (largely cardiorespiratory) systems issues, and fatigue of adapted systems (due to aging, under-and overuse, and pathophysiology). The product is a volume that provides compre­ of processes that operate from the forebrain to the contractile proteins.

Addressing the molecular mechanisms by which contraction of heart and skeletal muscles is regulated, this text also covers the modulation of these mechanisms by important (patho)physiological variables such as ionic composition of the myoplasm and phosphorylations of contractile and regulatory proteins. For the novice, this volume includes chapters that summarize current understanding of excitation-contraction coupling in striated muscles at the beginning of the 21st century, as well as the compositions and structures myofibrillar thick and thin filaments. For the expert, this volume presents detailed pictures of current understanding of the mechanisms underlying the CA2+ regulation of contraction in heart and skeletal muscles in 2002 and discusses important directions for future investigation.

This collection of contributions on the subject of the neural mechanisms of sensorimotor control resulted from a conference held in Cairns, Australia, September 3-6, 2001. While the three of us were attending the International Union of Physiological Sciences (IUPS) Congress in St Petersburg, Russia, in 1997, we discussed the implications of the next Congress being awarded to New Zealand. We agreed to organise a satellite to this congress in an area of mutual interest -the neuroscience of movement and sensation. Australia has a long-standing and enviable reputation in the field of neural mechanisms of sensorimotor control. Arguably this reached its peak with the award of a Nobel Prize to Sir John Eccles in 1963 for his work on synaptic transmission in the central nervous system. Since that time, the subject of neuroscience has progressed considerably. One advance is the exploitation of knowledge acquired from animal experiments to studies on conscious human subjects. In this development, Australians have achieved international prominence, particularly in the areas of kinaesthesia and movement control. This bias is evident in the choice of subject matter for the conference and, subsequently, this book. It was also decided to assign a whole section to muscle mechanics, a subject that is often left out altogether from conferences on motor control. Cairns is a lovely city and September is a good time to visit it.