Simon G. Thompson - Böcker

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics.Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments.FeaturesOffers first-hand, in-depth guidance on Mendelian randomization from leaders in the fieldMakes the diverse aspects of Mendelian randomization understandable to newcomersIllustrates technical details using data from applied analysesDiscusses possible future directions for research involving Mendelian randomizationSoftware code is provided in the relevant chapters and is also available at the supplementary websiteThis book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data.New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics.Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments.FeaturesOffers first-hand, in-depth guidance on Mendelian randomization from leaders in the fieldMakes the diverse aspects of Mendelian randomization understandable to newcomersIllustrates technical details using data from applied analysesDiscusses possible future directions for research involving Mendelian randomizationSoftware code is provided in the relevant chapters and is also available at the supplementary websiteThis book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data.New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

Defence applications are subject to some of the world’s most demanding requirements for reliability, controllability, security, flexibility, and synchronization. The evolution of defence processes towards network enabled systems and rapid deployment scenarios, is creating an urgent demand for highly adaptive and autonomous information support systems. In particular there are requirements for reduced manpower in support roles, autonomous IT infrastructures, and automated logistics and planning, all of which provide significant scope for an agent-oriented solution set. The workshop addresses the use of agent systems and agent applications applied to defence scenarios in support of these requirements.This book constitutes the thoroughly refereed post-proceedings of the International Workshop on Defence Applications of Multi-Agent Systems, DAMAS 2005, held in Utrecht, The Netherlands in July 2005 as an associated event of AAMAS 2005, the main international conference on autonomous agents and multi-agent systems. The 10 revised full papers presented together with 1 invited article are organized in topical sections on decision support and simulation, unmanned aerial vehicles, as well as on systems and security.