Stephen Burgess - Böcker

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics.Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments.FeaturesOffers first-hand, in-depth guidance on Mendelian randomization from leaders in the fieldMakes the diverse aspects of Mendelian randomization understandable to newcomersIllustrates technical details using data from applied analysesDiscusses possible future directions for research involving Mendelian randomizationSoftware code is provided in the relevant chapters and is also available at the supplementary websiteThis book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data.New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

Small businesses make up some 90-95 percent of all global firms. Many undervalue the importance of information and communication technology (ICT). Within the small business segment there can be significant differences amongst the avid early adopters of ICT and the laggards. Research on early adopters tends be more prevalent as they are perceived to have a more interesting and positive story. However, late adopters and ‘laggards’ also have their own interesting stories that are under-reported.Small Business and Effective ICT draws on research undertaken over several years and documents the adoption/use of ICT across ‘better’ users of ICT (Leaders), typical ICT users (Operationals) and late adopters (Laggards). The findings are presented using a re-formulation of the LIASE framework which addresses a number of areas that include ICT literacy (L), information content/communication (I), Access (A), Infrastructure (I), Support (S) and Evaluation (E). Some 60 businesses were investigated in Australia and the UK, with each business presented as a concise vignette. The vignettes serve to show that small businesses are not as conservative in their use of ICT as the literature suggests, with examples of innovative uses of ICT in small businesses provided. Lessons for the effective use of ICT by small businesses are presented.The research design, methods adopted, presentation of findings through the vignettes, and ‘take away’ lessons have been written in manner to appeal to a broad range of readers including academics, researchers, students and policy makers in the discipline.

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics.Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments.FeaturesOffers first-hand, in-depth guidance on Mendelian randomization from leaders in the fieldMakes the diverse aspects of Mendelian randomization understandable to newcomersIllustrates technical details using data from applied analysesDiscusses possible future directions for research involving Mendelian randomizationSoftware code is provided in the relevant chapters and is also available at the supplementary websiteThis book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data.New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

Small businesses make up some 90-95 percent of all global firms. Many undervalue the importance of information and communication technology (ICT). Within the small business segment there can be significant differences amongst the avid early adopters of ICT and the laggards. Research on early adopters tends be more prevalent as they are perceived to have a more interesting and positive story. However, late adopters and ‘laggards’ also have their own interesting stories that are under-reported.Small Business and Effective ICT draws on research undertaken over several years and documents the adoption/use of ICT across ‘better’ users of ICT (Leaders), typical ICT users (Operationals) and late adopters (Laggards). The findings are presented using a re-formulation of the LIASE framework which addresses a number of areas that include ICT literacy (L), information content/communication (I), Access (A), Infrastructure (I), Support (S) and Evaluation (E). Some 60 businesses were investigated in Australia and the UK, with each business presented as a concise vignette. The vignettes serve to show that small businesses are not as conservative in their use of ICT as the literature suggests, with examples of innovative uses of ICT in small businesses provided. Lessons for the effective use of ICT by small businesses are presented.The research design, methods adopted, presentation of findings through the vignettes, and ‘take away’ lessons have been written in manner to appeal to a broad range of readers including academics, researchers, students and policy makers in the discipline.