Solomon L. Moshe – författare

An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy.Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments.Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research.- The first comprehensive description of animal models of epilepsy since the early 1970''s- Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer- Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research- World expert opinions on the clinical relevance of each model

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals.- Provides a comprehensive reference detailing animal models of epilepsy and seizure- Offers insights on the use of novel technologies that can be applied in experimental epilepsy research- Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques- Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Keynote Adress. Genetic Predisposition and Kindling Susceptibility in Primates; J.A. Wada. Developmental Patterns. Idiosyncrasies of Limbic Kindling in Developing Rats; K.Z. Haas, et al. Long-Term Effects of Kindling on Learning and Memory in the Developing Brain; M. Sarkisian, et al. Electrophysiological Mechanisms. Long-Lasting Prolongation of NMDA Channel Openings after Kindling; I. Mody, D.N. Lieberman. Morphological and Anatomical Mechanisms. Role of Rhinencephalic Networks in Early Stage Kindling; J.L. Burchfiel. Synaptic Pharmacology and Neurochemistry of Kindling. Regionally Specific Changes in Glatamate and GABAA Receptors, PKC Isozymes, and Ionic Channels in Kindling Epileptogenesis of the Hippocampus of the Rat; F.H. Lopes da Silva, et al. Behavioral Effects of Kindling. Amygdala Kindling and Rodent Anxiety; R. Adamec. Drugs and Kindling. Protective Effect of Brain-Derived Neurotrophic Factor in Hippocampal Kindling; S. Reybiel. Clinical Implications of Kindling. The Syndrome of Mesial Temporal Lobe Epilepsy: A Role for Kindling; J. Engel. 27 additional articles. Index.

Proceedings of the Sixth International Conference on Kindling. Speakers at the conference will write chapters summarizing their current cutting-edge research on the kindling of seizures and related phenomena in epilepsy. The Kindling Conferences and the books arising from them (Kindling, Kindling 2-Kindling 5) have provided valuable summaries of the ongoing research on seizure development, with an emphasis on mechanisms, consequences, and potential treatments that might offset epileptogenesis. The general themes of talks and chapters at the Sixth Conference on Kindling are: pathogenesis, behavioral effects, drugs and interventions against kindling, and clinical relevance.

Proceedings of the Sixth International Conference on Kindling. Speakers at the conference will write chapters summarizing their current cutting-edge research on the kindling of seizures and related phenomena in epilepsy. The Kindling Conferences and the books arising from them (Kindling, Kindling 2-Kindling 5) have provided valuable summaries of the ongoing research on seizure development, with an emphasis on mechanisms, consequences, and potential treatments that might offset epileptogenesis. The general themes of talks and chapters at the Sixth Conference on Kindling are: pathogenesis, behavioral effects, drugs and interventions against kindling, and clinical relevance.

The last Kindling Conference was organized by Dr. Juhn Wada and held at the Univer­ sity of British Columbia, Vancouver, B. C. , in 1989. In the intervening years, research on kin­ dling has proceeded at an explosive pace and significant advances have been made in our understanding of the molecular biological, anatomical, and physiological substrates of kin­ dling, as well as in our appreciation of the age-dependent effects and complex behavioral consequences of kindling, its sensitivity to drugs, and its relevance to the clinical epilepsies. In order to review these developments and to provide researchers with an opportunity to in­ teract face to face and discuss the issues that preoccupy us all, we organized the Fifth Interna­ tional Conference on Kindling, in Victoria, B. C. , in the summer of 1996. Most of the stalwarts in kindling research were invited, as were a number of investigators whose research on kindling has become prominent in the past few years. We continue to miss the late Graham Goddard, the discoverer of kindling, and were saddened by the recent death of Eric Lothman, a prolific researcher and clinician who would have been a prominent participant. We were deeply disturbed to learn of the death of Frank Morrell, one of the earliest kindlers and an eminent neurologist, who died several months after our conference.

The last Kindling Conference was organized by Dr. Juhn Wada and held at the Univer­ sity of British Columbia, Vancouver, B. C. , in 1989. In the intervening years, research on kin­ dling has proceeded at an explosive pace and significant advances have been made in our understanding of the molecular biological, anatomical, and physiological substrates of kin­ dling, as well as in our appreciation of the age-dependent effects and complex behavioral consequences of kindling, its sensitivity to drugs, and its relevance to the clinical epilepsies. In order to review these developments and to provide researchers with an opportunity to in­ teract face to face and discuss the issues that preoccupy us all, we organized the Fifth Interna­ tional Conference on Kindling, in Victoria, B. C. , in the summer of 1996. Most of the stalwarts in kindling research were invited, as were a number of investigators whose research on kindling has become prominent in the past few years. We continue to miss the late Graham Goddard, the discoverer of kindling, and were saddened by the recent death of Eric Lothman, a prolific researcher and clinician who would have been a prominent participant. We were deeply disturbed to learn of the death of Frank Morrell, one of the earliest kindlers and an eminent neurologist, who died several months after our conference.

Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies.  Offers a thorough discussion of epileptic seizure types and epilepsy syndromes, reflecting the latest research and knowledge throughout  Discusses major advances in the understanding of the basic mechanisms of epilepsy and seizures, including an expanded section on their genetic etiologies, their consequences and co-occurring conditions.  Presents state-of-the-art approaches for the diagnostic evaluation of individuals with seizures, pharmacotherapy and alternative treatments, and extensive discussions of the new antiseizure medications for managing seizure intensity and frequency, along with their side effects  Covers the latest developments in surgical approaches to treatment, including neuromodulation  Discusses psychiatric issues associated with epilepsy and conditions resembling seizures.  Presents the current state of global health care delivery for individuals with epilepsy  Shares the knowledge and expertise of contributing authors from 48 countries and nearly 300 institutions    Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech.