Stefan Dübel – författare

This volume presents the proceedings of an interdisciplinary workshop at Braunschweig University of Technology in a collection of English and German articles (English summaries are provided for all German articles). Focusing on biotechnology, experts from biology, biotechnology, ethics, philosophy, theology, education, and social sciences investigated how metaphors shape the language of life science. The authors examined conceptual, absolute, and hidden metaphors (e.g., “genetic scissors,” “genetic code,” “antibodies,” and “life”) in molecular biology and biotechnology. By exploring their roles in describing phenomena, guiding research, and influencing public perceptions, the authors investigate how metaphors generate and transform knowledge, affect views of life and therapy, and inspire innovation. This volume integrates systematic metaphor analysis with ethical, philosophical, and pedagogical perspectives on the significance of metaphors in biotechnology research and dissemination. Special attention was paid to metaphors’ role in public communication, potentially determining acceptance or rejection of biotechnological advances. Ultimately, the workshop underscored how metaphors influence scientific progress in multiple ways and therefore require critical reflection.

Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity."Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity."Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity."Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity."Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

Interest in recombinant antibody technologies has rapidly increased because of the wide range of possible applications in therapy and diagnosis, especially in cancer treatment. The possibility of generating human antibodies that are not accessible by conventional polyclonal or monoclonal approaches has forced the development of antibody engineering technologies even more.This manual presents a comprehensive collection of detailed, step-by-step protocols provided by experts in the field. All basic methods needed in antibody engineering - not only methods to generate recombinant antibodies, but also protocols for analysis and their use - and recently developed and emerging technologies are covered.

Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity."Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

Die vollständig überarbeitete zweite Auflage bietet eine umfassende Einführung in die grundlegenden Technologien wie auch in die vielfältigen Anwendungsgebiete rekombinant hergestellter und verbesserter Antikörper und ihrer unzähligen Varianten. Die einzelnen Kapitel gehen detailliert auf die Herstellung, die Charakterisierung, die Produktion und die Anwendungsgebiete für rekombinante Antikörper in Forschung, Diagnostik und Therapie ein. Die LeserInnen werden schrittweise an die zugrunde liegenden Prinzipien herangeführt und erhalten so einen leichten Zugang zu den komplexen Themen. Zahlreiche anschauliche Abbildungen, die einem ausgereiften didaktischen Farb- und Formenschema folgen, helfen dabei, die Zusammenhänge nachzuvollziehen. So können sich auch LeserInnen mit wenigen Vorkenntnissen die komplexe Welt der rekombinanten Antikörper in der Tiefe erschließen.