Stephan Schmidt – författare

This comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimer’s disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process.

Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection.  Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success.

This book provides readers with an overview of recent theories and methods for studying complex mechanical systems used in energy production, such as wind turbines, but not limited to them. The emphasis is put on strategies for increasing energy efficiency, and on recent industrial applications.  Topics cover dynamics and vibration, vibroacoustics, engineering design, modelling and simulation, fault diagnostics, signal processing and prognostics. The book is based on peer-review contributions and invited talks presented at the first International Workshop on MOdelling and Simulation of COmplex Systems for Sustainable Energy Efficiency, MOSCOSSEE 2021, held online on February 25-26, 2021, and organized by    the LAboratory of Mechanics, Modelling and Production (LA2MP) from University of Sfax, Tunisia and the Department of Mechanical and Aeronautical engineering, Centre of Asset Integrity Management (C-AIM) from University of Pretoria, South Africa. By offering authoritative information on innovative methods and tools for application in renewable energy production, it provides a valuable resource to both academics and professionals, and a bridge to facilitate communication between the two groups.