This volume explores the latest techniques used to study how mesoscale imaging can be applied in various areas of neuroscientific research. The chapters in this book are organized into four parts: Part One highlights novel imaging modalities, such as neurotransmitter and single-cell resolution imaging and analyses of neuroimaging data in awake rodents. Part Two covers technical innovations such as head-mounted camera systems, multi-site photometry, and concurrent imaging-electrographic probes. Part Three presents methods of mesoscale imaging during normal behavior, and Part Four looks at the mesoscale imaging methods used to study neurological diseases and disorders that are critical to observe in the non-anesthetized condition. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and thorough, Awake Behaving Mesoscopic Brain Imaging is a valuable resource for both novice and expert researchers who are interested in learning more about this exciting and innovative topic.

Neurovascular Coupling Methods brings the reader up to date with the current state-of-the-art techniques in measuring blood flow in the brain, with chapters describing different techniques or combinations of techniques, applied to specific species in either healthy or abnormal brains. Opening with a section on techniques in normal somatosensory processing, the detailed volume continues with parts covering techniques in normal visual processing, epilepsy and cerebrovascular diseases, such as ischemia, hemorrhage and spreading depression. As a collection in the popular Neuromethods series, this book contains the kind of thorough description and implementation advice that will lead to successful results in the lab.

Authoritative and practical, Neurovascular Coupling Methods serves as an ideal guide for researchers aiming to further our knowledge of these coupling mechanisms in the hopes of ultimately understanding higher order functions such as language and memory and developing novel brain mapping techniques that can be employed in humans.

A comprehensive guide on current clinical management options for pituitary tumors -- including state-of-the-art endoscopic techniques

Thieme congratulates Theodore H. Schwartz on being chosen by New York magazine for its prestigious ‘Best Doctors 2015'' list.

Offering the unique dual perspective of neurosurgeons and otolaryngologists, Endoscopic Pituitary Surgery: Endocrine, Neuro-Ophthalmologic and Surgical Management describes both cutting-edge endoscopic techniques and tried-and-true decision-making methodologies that lead to the most successful outcomes. From choosing the right surgical or non-surgical approach for individual patients, to managing complex endocrine and neuro-ophthalmologic issues, this is the first major reference in the field in nearly a decade, making it the go-to guide for all interdisciplinary specialists who treat pituitary tumors.

Special Features:

Enhanced by hundreds of images, decision-making algorithms, and clinical pearls from experts on each tumor type, Endoscopic Pituitary Surgery is a comprehensive guide representing the current palette of available treatment options. It is indispensable for residents in training as well as for practicing neurosurgeons and otolaryngologists who are making the transition to the newest minimally invasive endoscopic procedures in the treatment of pituitary lesions.

The definitive state-of-the-art resource on pediatric endoscopic endonasal approaches

Today, expanded endonasal approaches (EEA) have revolutionized the surgical treatment paradigm for pediatric central skull base lesions. Specially adapted micro-instruments have been developed to permit passage through the narrow sinonasal pathways in children, enabling access to the entire midline skull base, from the crista galli to the cervico-medullary junction.

Pediatric Endoscopic Endonasal Skull Base Surgery by Harminder Singh, Jeffrey Greenfield, Vijay Anand, and Theodore Schwartz is the first textbook focused solely on endoscopic endonasal management of cranial base pathologies in children. The book reflects in-depth expertise from an extraordinary group of international contributors from five continents, who share extensive knowledge on this emerging field. Thirty chapters are presented in three comprehensive sections.

Key Features

This unique reference is essential reading for neurosurgical and otolaryngology residents and fellows, as well as veteran surgeons, nurse-practitioners, and physician-assistants who treat and care for pediatric patients with skull-base conditions.

Endoscopic transorbital surgery of the orbit, skull base and brain is a new surgical discipline that has developed over the last decade out of a collaboration between otolaryngologists, neurosurgeons and oculoplastic surgeons. Tumors and other pathology of the skull base are some of the most difficult to approach and treat for surgeons since they lie at the interface of several traditional specialties, namely the eye, the paranasal sinuses and the brain. For this reason, no single surgical specialty is fully trained to independently reach this region, which requires collaborative approaches that are technically demanding and often long and arduous procedures.

In the last decade, using the endoscopic techniques and instrumentation, otolaryngologists, oculoplastic surgeons and neurosurgeons, have together shown that the orbit can be used as a minimally disruptive corridor to reach the skull base lateral to the carotid artery as well as other areas that are difficult to access through transcranial or endonasal approaches. These approaches are now even being used to remove brain tumors involving the frontal and temporal lobes, including those that extend through the middle cranial fossa and into the posterior fossa, without visible external scars or the need for a traditional craniotomy. In addition, they have been used to clip aneurysms, treat seizure disorders, drain abscesses, repair CSF (brain fluid) leaks, and restore skull fractures – all without the additional risks, trauma and prolonged recovery of previous open surgical techniques. The literature is now demonstrating that these endoscopic procedures have comparable or improved safety compared to open surgery, while creating less collateral damage, and result in reduced patient stays.

Due to their novelty, few surgeons have acquired the necessary experience, knowledge and expertise to introduce these approaches into their practice, yet due to their safety and efficacy they are rapidly becoming a critical skill set. This is the first text of its kind to codify and proliferate these new approaches more rapidly through the country and world, appealing to otolaryngologists, oculoplastic surgeons and neurosurgeons who deal with pathology involving the skull base.

This volume explores the latest techniques used to study how mesoscale imaging can be applied in various areas of neuroscientific research. The chapters in this book are organized into four parts: Part One highlights novel imaging modalities, such as neurotransmitter and single-cell resolution imaging and analyses of neuroimaging data in awake rodents. Part Two covers technical innovations such as head-mounted camera systems, multi-site photometry, and concurrent imaging-electrographic probes. Part Three presents methods of mesoscale imaging during normal behavior, and Part Four looks at the mesoscale imaging methods used to study neurological diseases and disorders that are critical to observe in the non-anesthetized condition. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and thorough, Awake Behaving Mesoscopic Brain Imaging is a valuable resource for both novice and expert researchers who are interested in learning more about this exciting and innovative topic.

Neurovascular Coupling Methods brings the reader up to date with the current state-of-the-art techniques in measuring blood flow in the brain, with chapters describing different techniques or combinations of techniques, applied to specific species in either healthy or abnormal brains. Opening with a section on techniques in normal somatosensory processing, the detailed volume continues with parts covering techniques in normal visual processing, epilepsy and cerebrovascular diseases, such as ischemia, hemorrhage and spreading depression. As a collection in the popular Neuromethods series, this book contains the kind of thorough description and implementation advice that will lead to successful results in the lab.

Authoritative and practical, Neurovascular Coupling Methods serves as an ideal guide for researchers aiming to further our knowledge of these coupling mechanisms in the hopes of ultimately understanding higher order functions such as language and memory and developing novel brain mapping techniques that can be employed in humans.

A comprehensive guide on current clinical management options for pituitary tumors -- including state-of-the-art endoscopic techniques

Thieme congratulates Theodore H. Schwartz on being chosen by New York magazine for its prestigious ‘Best Doctors 2015'' list.

Offering the unique dual perspective of neurosurgeons and otolaryngologists, Endoscopic Pituitary Surgery: Endocrine, Neuro-Ophthalmologic and Surgical Management describes both cutting-edge endoscopic techniques and tried-and-true decision-making methodologies that lead to the most successful outcomes. From choosing the right surgical or non-surgical approach for individual patients, to managing complex endocrine and neuro-ophthalmologic issues, this is the first major reference in the field in nearly a decade, making it the go-to guide for all interdisciplinary specialists who treat pituitary tumors.

Special Features:

Enhanced by hundreds of images, decision-making algorithms, and clinical pearls from experts on each tumor type, Endoscopic Pituitary Surgery is a comprehensive guide representing the current palette of available treatment options. It is indispensable for residents in training as well as for practicing neurosurgeons and otolaryngologists who are making the transition to the newest minimally invasive endoscopic procedures in the treatment of pituitary lesions.

The definitive state-of-the-art resource on pediatric endoscopic endonasal approaches

Today, expanded endonasal approaches (EEA) have revolutionized the surgical treatment paradigm for pediatric central skull base lesions. Specially adapted micro-instruments have been developed to permit passage through the narrow sinonasal pathways in children, enabling access to the entire midline skull base, from the crista galli to the cervico-medullary junction.

Pediatric Endoscopic Endonasal Skull Base Surgery by Harminder Singh, Jeffrey Greenfield, Vijay Anand, and Theodore Schwartz is the first textbook focused solely on endoscopic endonasal management of cranial base pathologies in children. The book reflects in-depth expertise from an extraordinary group of international contributors from five continents, who share extensive knowledge on this emerging field. Thirty chapters are presented in three comprehensive sections.

Key Features

This unique reference is essential reading for neurosurgical and otolaryngology residents and fellows, as well as veteran surgeons, nurse-practitioners, and physician-assistants who treat and care for pediatric patients with skull-base conditions.

Endoscopic transorbital surgery of the orbit, skull base and brain is a new surgical discipline that has developed over the last decade out of a collaboration between otolaryngologists, neurosurgeons and oculoplastic surgeons. Tumors and other pathology of the skull base are some of the most difficult to approach and treat for surgeons since they lie at the interface of several traditional specialties, namely the eye, the paranasal sinuses and the brain. For this reason, no single surgical specialty is fully trained to independently reach this region, which requires collaborative approaches that are technically demanding and often long and arduous procedures.

In the last decade, using the endoscopic techniques and instrumentation, otolaryngologists, oculoplastic surgeons and neurosurgeons, have together shown that the orbit can be used as a minimally disruptive corridor to reach the skull base lateral to the carotid artery as well as other areas that are difficult to access through transcranial or endonasal approaches. These approaches are now even being used to remove brain tumors involving the frontal and temporal lobes, including those that extend through the middle cranial fossa and into the posterior fossa, without visible external scars or the need for a traditional craniotomy. In addition, they have been used to clip aneurysms, treat seizure disorders, drain abscesses, repair CSF (brain fluid) leaks, and restore skull fractures – all without the additional risks, trauma and prolonged recovery of previous open surgical techniques. The literature is now demonstrating that these endoscopic procedures have comparable or improved safety compared to open surgery, while creating less collateral damage, and result in reduced patient stays.

Due to their novelty, few surgeons have acquired the necessary experience, knowledge and expertise to introduce these approaches into their practice, yet due to their safety and efficacy they are rapidly becoming a critical skill set. This is the first text of its kind to codify and proliferate these new approaches more rapidly through the country and world, appealing to otolaryngologists, oculoplastic surgeons and neurosurgeons who deal with pathology involving the skull base.