Thisbe K Lindhorst – författare

With the increase in volume, velocity and variety of information, researchers can find it difficult to keep up to date with the literature in the field. As the synthesis of novel carbohydrates and carbohydrate mimetics continues to be a major challenge for organic chemists, not least because of the increasingly interdisciplinary nature of carbohydrate science, Carbohydrate Chemistry Volume 41 will prove invaluable. Covering both chemical and biological science, this series collates modern carbohydrate research from theory to application and will be of great benefit to any researcher who wishes to learn about the latest developments in the carbohydrate field.

The understanding of the structure and function of carbohydrates and glycoconjugates remains vital in many fields, notably in medicine and molecular biology. This new volume of Carbohydrate Chemistry contains critical reviews covering the latest findings in both chemical and biological sciences, and demonstrates the interdisciplinary nature of modern carbohydrate research. This book addresses diverse applications that continue to be major challenges for carbohydrate chemists. The oxidative deamination reactions and synthesis of N-acetylneuraminic acid derivatives, ketoheptoses, lipid A and analogs, the fascinating world of complex glycans in the interplay with Siglecs, carbohydrates and regenerative medicine, chemistry for the stereocontrol of glycosylation, and the impact of gold chemistry in carbohydrate research are some of the topics presented in this volume 44, which will certainly benefit any researcher who wishes to learn about the latest developments in the carbohydrate field.

In many fields, most notably medicine and molecular biology, the understanding of the structure and function of carbohydrates and glycoconjugates remains vital. This new volume contains critical reviews covering the latest findings in both chemical and biological sciences, and demonstrates the interdisciplinary nature of modern carbohydrate research. This book addresses diverse applications that continue to be major challenges for carbohydrate chemists. The book starts with a review of Gérard Descotes contribution to the field as a pioneer of French modern carbohydrate chemistry. Green nanocatalytic oxidation of free sugars, photosensitive glycomacrocycles, the application of disaccharides in supramolecular chemistry, recent advances in the radiation chemistry of polysaccharides, and the cell wall pectic rhamnogalacturonan II, an enigma in plant glycobiology are just some of the diverse topics presented in Volume 45. This set of reports will certainly benefit any researcher who wishes to learn about the latest developments in the carbohydrate field.

The understanding of (patho)physiological processes - the biosynthesis of biomolecules such as enzymes, nucleic acids, and secondary metabolites; the pathways of signaltransduction; or the function of pharmaceutical agents - is of increasing importance not only for drug research but also for the development of new synthetic methods in organic chemistry and biochemistry. In a truly interdisciplinary way bioorganic chemistry unites the central questions of biochemistry, medicinal chemistry, organic chemistry, and spectroscopy. This book fills a void in this rapidly growing field of chemistry and gives a thorough yet understandable introduction for advanced students and researchers alike. Contributions of more than sixty scientists provide a topical overview of recent advances in: drug development based on natural products; the biosynthesis, activity, and application of enzymes; carbohydrates; peptides; nucleic acids; analytical methods in bioorganic chemistry. This book will be an appetizer for all - students and researchers alike - seeking orientation in this fascinating field of chemistry.

Concise yet complete, this is a succinct introduction to the topic, covering both basic chemistry as well as such advanced topics as high-throughput analytics and glycomics -- in one handy volume. This improved and expanded 3rd edition features all-new material on combinatorial synthesis of carbohydrates and carbohydrate biodiversity, and each chapter now contains study questions for self-learning and classroom teaching. Didactically written by an experienced lecturer and graduate student advisor, the text is backed by practical examples and more than 150 study questions tailored to students' needs.

Eine bunte und überraschende Abenteuerreise durch die faszinierenden Weiten des Chemie-Universums: Wie erklärt die Chemie die Entstehung des Lebens, wie hat sie die Welt verändert und wie lassen sich die drängenden Probleme unserer Zeit mit ihrer Hilfe lösen? In zwölf Kapiteln geben uns ausgesuchte Spezialisten, Chemiker und Chemikerinnen einen Einblick in die Chemie als äußerst kreative und verantwortungsbewusste Wissenschaft. Viele praktische Beispiele, Produkte und Anwendungen zeigen das Potential der Chemie auf. So erfährt man etwa, dass eine moderne Energie- und Rohstoffversorgung ohne Chemie weder denkbar noch machbar ist und welche Bedeutung die Chemie für die moderne Informationstechnologie hat. Ein besonderes Augenmerk wird darauf gerichtet, welche Rolle die Chemie bei aktuellen und zukünftigen Herausforderungen unserer Gesellschaft spielt: Die ungebrochen wachsende Weltbevölkerung, die drohende Knappheit von Nahrung und Wasser, die Gesundheitsvorsorge und Heilung von Krankheiten, der ansteigende Energieverbrauch sowie der Erhalt unserer Lebensqualität - als stark interdisziplinär orientierte Wissenschaft schafft die Chemie die Grundlagen, um diese dringenden Probleme unserer Zeit nachhaltig anzugehen. Quo vadis Chemie? In diesem Buch wird kritisch und fachkundig diskutiert, wie sich die Chemie entwickeln muss, um diesen Aufgaben gerecht zu werden. Heute gelingt schon vieles, dennoch werden neue Denkansätze und innovative Prozesse und Produkte für die Zukunft gebraucht. Ohne Chemie ist keine Lösung möglich.Ein spannendes und informatives Buch für alle, die sich für Chemie und für die Welt, in der wir leben, interessieren und gerne wissen möchten, welche Rolle die Chemie nicht nur heute wahrnimmt, sondern vor allem zukünftig spielen sollte.

Thoroughly updated edition of the leading textbook on carbohydrate chemistry From synthesis to biological function, Essentials of Carbohydrate Chemistry and Biochemistry introduces the entire range of modern carbohydrate chemistry and chemical biology. In this new edition, the increasing recognition of the role of carbohydrates in biology, pharmacology, and medicine is reflected in greatly expanded sections on glycobiology and glycomimetics. The new edition also features a new set of illustrations, many of which are now in color, as well as intriguing practical examples and story-telling text boxes providing context for the relevance of carbohydrates in science and society. Didactically written by an experienced lecturer and graduate student advisor, Essentials of Carbohydrate Chemistry and Biochemistry includes information on: Protecting groups for carbohydrates, including protection of the anomeric center, acyl, ether, and acetal protecting groupsMethods for the analysis of carbohydrates, covering polarimetry, NMR spectroscopy, and mass spectrometryImportant modifications and functionalizations of the sugar ring, such as deoxy derivatives, anhydro sugars, and epimerizationsPrincipal approaches to the chemical and enzymatic synthesis of glycosides and glycopeptides, and modern examples of advancing the art of glycoside synthesis employing solution as well as solid phase methodsStructural diversity and biosynthesis of oligosaccharides and glycoconjugatesA greatly expanded section on glycobiology that focuses on the role of carbohydrates in membrane architecture, cell-cell-recognition. cell adhesion, and their biomedical applicationsUpdated and thoroughly modernized for more efficient classroom teaching and self-learning, the Fourth Edition of Essentials of Carbohydrate Chemistry and Biochemistry is essential reading for students in chemistry, biochemistry, biotechnology, and pharmacy with an interest in glycochemistry and glycobiology.

bacterial carbohydrate recognition are conveyed, covering Gram-positive as well as Gram-negative bacteria, in Chapter 4 Streptococci and Staphylococci, and in Chapter 5, carbohydrate binding specificities of Helicobacter pylori. In Chapter 6, "Bitter sweetness of complexity," the collected reflections on mic- bial adhesion are expanded by a perspective on a broader impact of glycosylation on cellular adhesion, motility and regulatory processes, paralleling the complexity of N-glycan structures on cell surfaces. It highlights particularly how structural details of N-glycans have been causally related to pathological scenarios, with a focus on ?(1,6)-N-acetylglucosaminyltransferase. In the final chapter, biofilm formation is reviewed, covering knowledge about structure and biosynthesis of polysaccharide intercellular adhesins (PIAs) which are central to biofilm formation. This comprehensive chapter explains all PIA-related principles of medical device-associated infections.It is our hope, that this collection of expert articles, ranging from structural ch- istry and structural biology to biochemistry and medicine, will be a stimulation and motivation for our colleagues in the life sciences. At the same time, we hope that these reflections on microbial adhesion will awake interest in and promote und- standing of the complex processes associated with the glycocalyx and the multif- eted interactions between the host cell and its "guest," as well as the biological consequences resulting from this mutual interplay.