Torsten Haferlach – författare

Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practiceThe revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day.Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems. Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color imagesExplores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entitiesProvides a quick and easy reference of key diagnostic issues in a comprehensive yet concise formatIncludes and illustrates the WHO Classification of Hematologic MalignanciesIllustrates the new knowledge of the molecular basis of inherited and acquired blood diseasesColor Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology."Substantially updated and now multi-authored so that all aspects of haematology are equally covered, including the newest developments in molecular biology and genomic sequencing""There is a surplus of invention in communicating complex problems here and an admirable effort to keep the reader totally up-to-date"

In the 6th edition of this atlas the WHO classification published in 2001 has been integrated and recently described types of leukemia and lymphoma have been documented by figures and descriptions. Among these are leukeumias of dendritic cells, rare lymphomas and the persistent polyclonal B lymphocytosis which takes an exceptional position.All microscopical methods in haematology forming the basics of diagnostic are presented as well as modern immunologic, cytogenetic and molecular-genetic results. Special reference is placed on cytogenetic and molecular-genetic characterization of biological entities which might form the basis for innovative therapies.Normal results and pathological findings are compared. Alos the different findings during therapy are shown. Thus the Atlas of Clinical Hematology is a complete and helpful reference work which should be present in every haematological and oncological department as well as in clincial laboratories for online diagnostics and scientific research

This 6th edition of the atlas has integrated the 2001 WHO classification and made use of figures and descriptions to document recently described types of leukemia and lymphoma. The latter include leukemias of dendritic cells, rare lymphomas and persistent polyclonal B lymphocytosis, which takes a special place in the classification.The volume covers all the microscopic methods in hematology that form the basis of diagnosis as well as the results of modern immunologic, cytogenetic and molecular-genetic investigation. Special emphasis is placed on the cytogenetic and molecular-genetic characterization of biological entities that might form the basis for innovative therapies.Normal results and pathological findings are compared, and the various findings made during therapy are depicted. All in all the Atlas of Clinical Hematology represents a complete and helpful reference work which should be present in every hematologic and oncologic department as well as in clinical laboratories for online diagnostics and scientific research.

The diagnosis of myelodysplastic syndromes (MDS), a heterogeneous group of clonal hematopoietic disorders, is being made with increasing frequency over the past decade owing to increased recognition, improved understanding, and an aging population. This book, completely updated since the first edition, summarizes in a concise and focused way the current knowledge of all aspects of MDS. Clinical presentation, etiology, epidemiology, molecular biology, classification, and staging are all discussed. Clear guidance is provided on diagnosis and differential diagnosis, and treatment strategies are explained in detail, including administration of hematopoietic growth factors, biologically based treatment, hematopoietic stem cell transplantation, and supportive care. Additional chapter is devoted to MDS in children. This practically oriented book will be of value to a broad spectrum of students and practitioners in the field.

The diagnosis of myelodysplastic syndromes (MDS), a heterogeneous group of clonal hematopoietic disorders, is being made with increasing frequency over the past decade owing to increased recognition, improved understanding, and an aging population. This book, completely updated since the first edition, summarizes in a concise and focused way the current knowledge of all aspects of MDS. Clinical presentation, etiology, epidemiology, molecular biology, classification, and staging are all discussed. Clear guidance is provided on diagnosis and differential diagnosis, and treatment strategies are explained in detail, including administration of hematopoietic growth factors, biologically based treatment, hematopoietic stem cell transplantation, and supportive care. Additional chapter is devoted to MDS in children. This practically oriented book will be of value to a broad spectrum of students and practitioners in the field.

Knapp und präzise ist zu häufigen und seltenen Krankheitsbildern, die für die tägliche Routine des Hämatologen relevant sind, das diagnostische Vorgehen beschrieben. Von der Zytomorphologie ausgehend werden die notwendigen Bezüge zur Zytogenetik, Molekulargenetik und Immunologie mit einbezogen. Über 800 Abbildungen von typischen Blut- und Knochenmarkausstrichen illustrieren die Befunde und können als Vergleichsbilder für die eigene Diagnostik verwendet werden. Die aktuelle WHO-Klassifikation von 2017 ist umfassend berücksichtigt.Neu in dieser 3. Auflage ist neben der Darstellung der WHO-relevanten Diagnosen und Befunde eine noch intensivere Betonung der Bezüge zwischen Phänotyp und Genotyp der hämatologischen Erkrankungen. Dieses Konzept entspricht nicht nur aktuell dem klinisch notwendigen Standard, sondern zeigt auch den Weg in eine zukünftig zunehmend Genotyp-basierte Vorgehensweise mit dem Ziel der sog. Präzisions-Medizin auf.