Torsten Hoffmann - Böcker

This volume presents the proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: structure and function of dipeptidyl aminopeptidases, DPP IV-like proteins, immune mechanisms and immune disorders, cancer and angiogenesis, diabetes and metabolism, therapeutic implications.

Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.

The sublime - along with beauty the most important aesthetic category of the 18th century - experienced an amazing renaissance in art, philosophy and scholarship at the end of the 20th century. Using the examples of Peter Handke, Christoph Ransmayr, Botho Strauss and Raoul Schrott, the present study shows the extent to which notions of the sublime have proved productive in contemporary literature. Particular attention is paid to the interrelationships between the literary texts and the aesthetic theories of Immanuel Kant, Friedrich Schiller, Jean-Francois Lyotard and Martin Seel, among others. The study demonstrates the multiplicity of forms in which the sublime appears in literature - and shows how the traditional idea of the sublime in human superiority over nature has been transformed into a poetics of sublime weakness.