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The brain consisting of billions of neurons is probably the most complex and mysterious organ of the body. Understanding the functioning of the brain in its health and disease states has baffled the researchers working in this area for many years. The diversity of brain diseases and disorders makes the analysis of brain functions an even more challenging area of research. In vitro and in vivo studies regarding the brain may be laborious, however, bioinformatics using in silico approaches may take the burden off the experimental studies and give us a clearer perspective on disease and healthy states of the brain, its functions, and disease mechanisms.Recent advancements in neuroimaging technologies, the development of high-performance computers and the development of software, algorithms and methods to analyze data obtained from various neuroimaging processes have opened new frontiers in neuroscience enabling unprecedented finer analysis of the brain functions. This relatively new approach of brain analysis which may be termed Bioinformatics of the Brain is the main subject of this volume aiming to provide a thorough review of various bioinformatics approaches for analyzing the functioning of the brain and understanding brain diseases such as neurodegenerative diseases, brain tumors, and neuropsychiatric disorders. Authors from various disciplines in this volume each focus on a different aspect aiming to expand our understanding of this area of research. Topics included are:Brain diseases and disordersStem cell therapy of neurodegenerative diseasesTissue engineering applications of gliomasBrain tumor detection and modelingBrain tumor growth simulationBrain-computer interfaceBioinformatics of brain diseasesGraph-theoretical analysis of complex brain networksBrain proteomicsThis book is intended to aid scientists, researchers, and graduate students in carrying out interdisciplinary research in the areas of bioinformatics, bioengineering, computer engineering, software engineering, mathematics, molecular biology, genetics, and biotechnology.
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The brain consisting of billions of neurons is probably the most complex and mysterious organ of the body. Understanding the functioning of the brain in its health and disease states has baffled the researchers working in this area for many years. The diversity of brain diseases and disorders makes the analysis of brain functions an even more challenging area of research. In vitro and in vivo studies regarding the brain may be laborious, however, bioinformatics using in silico approaches may take the burden off the experimental studies and give us a clearer perspective on disease and healthy states of the brain, its functions, and disease mechanisms.Recent advancements in neuroimaging technologies, the development of high-performance computers and the development of software, algorithms and methods to analyze data obtained from various neuroimaging processes have opened new frontiers in neuroscience enabling unprecedented finer analysis of the brain functions. This relatively new approach of brain analysis which may be termed Bioinformatics of the Brain is the main subject of this volume aiming to provide a thorough review of various bioinformatics approaches for analyzing the functioning of the brain and understanding brain diseases such as neurodegenerative diseases, brain tumors, and neuropsychiatric disorders. Authors from various disciplines in this volume each focus on a different aspect aiming to expand our understanding of this area of research. Topics included are:Brain diseases and disordersStem cell therapy of neurodegenerative diseasesTissue engineering applications of gliomasBrain tumor detection and modelingBrain tumor growth simulationBrain-computer interfaceBioinformatics of brain diseasesGraph-theoretical analysis of complex brain networksBrain proteomicsThis book is intended to aid scientists, researchers, and graduate students in carrying out interdisciplinary research in the areas of bioinformatics, bioengineering, computer engineering, software engineering, mathematics, molecular biology, genetics, and biotechnology.
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Kommande
Inflammation and Reproduction reviews the impact of inflammation on reproductive health and includes the role of genetics and molecular pathways in modulating interactions between these two often conflicting processes. Evidence-based and conventional therapies, as well as alternative therapies (e.g. and bioengineered tissues), are summarized. Discussions also include other factors such as microbiota associations and the effects of stress on biological clocks. Topics include the use of bioinformatics in the study of inflammatory reproductive disorders which might employ machine learning models in predicting cervical cancer and other factors contributing to reproductive health or disease. The following are the certain featured issues covered in this volume:The role of microbiota in modulating inflammationProtective and regulatory aspects of antioxidants on reproductive functionImpacts of sleep and stress, as well as lifestyle choices, on inflammatory pathways and reproductive outcomesA detailed discussion on inflammatory signaling pathways involved in reproductive cancersComputational studies that elucidate the mechanisms linking inflammation and reproductive healthThe current and emerging therapeutic strategies, including treatment options for inflammatory reproductive disorders, advances in stem cell–based therapies, and the application of bioengineered tissues for restoring reproductive function and treating infertility