Valerii V. Fedorov – författare
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7 produkter
7 produkter
Häftad, Engelska, 2019
1 005 kr
Skickas inom 10-15 vardagar
Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors’ many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. The authors also discuss adaptive designs, focusing on procedures with non-informative stopping. The common goals of experimental design—such as reducing costs, supporting efficient decision making, and gaining maximum information under various constraints—are often the same across diverse applied areas. Ethical and regulatory aspects play a much more prominent role in biological, medical, and pharmaceutical research. The authors address all of these issues through many examples in the book.
E-bok
Engelska, 20131 194 kr
Läs direkt efter köp
Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors' many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of
Del 209 - Lecture Notes in Statistics
Model-Oriented Design of Experiments
Häftad, Engelska, 2024
1 083 kr
Skickas inom 10-15 vardagar
This book presents the basic ideas of statistical methods in the design of optimal experiments. This new edition now includes sections on design techniques based on the elemental Fisher information matrices (as opposed to Pearson information/moment matrices), allowing a seamless extension of the design techniques to inferential problems where the shape of distributions is essential for optimal design construction. Topics include designs for nonlinear models, models with random parameters and models with correlated observations, designs for model discrimination and misspecified (contaminated) models, and designs in functional spaces.The authors avoid technical details, assuming a moderate background in calculus, matrix algebra, and statistics. In many places, however, suggestions are made as to how the ideas presented in this book can be extended and elaborated for use in real scientific research and practical engineering problems.
E-bok
Engelska, 20241 367 kr
Läs direkt efter köp
This book presents the basic ideas of statistical methods in the design of optimal experiments. This new edition now includes sections on design techniques based on the elemental Fisher information matrices (as opposed to Pearson information/moment matrices), allowing a seamless extension of the design techniques to inferential problems where the shape of distributions is essential for optimal design construction. Topics include designs for nonlinear models, models with random parameters and models with correlated observations, designs for model discrimination and misspecified (contaminated) models, and designs in functional spaces.
The authors avoid technical details, assuming a moderate background in calculus, matrix algebra, and statistics. In many places, however, suggestions are made as to how the ideas presented in this book can be extended and elaborated for use in real scientific research and practical engineering problems.
Inbunden, Engelska, 2013
2 424 kr
Skickas inom 10-15 vardagar
Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors’ many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. The authors also discuss adaptive designs, focusing on procedures with non-informative stopping. The common goals of experimental design—such as reducing costs, supporting efficient decision making, and gaining maximum information under various constraints—are often the same across diverse applied areas. Ethical and regulatory aspects play a much more prominent role in biological, medical, and pharmaceutical research. The authors address all of these issues through many examples in the book.
E-bok
PDF, Engelska, 20131 194 kr
Läs direkt efter köp
Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors' many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of
E-bok
PDF, Engelska, 20121 379 kr
Läs direkt efter köp
These lecture notes are based on the theory of experimental design for courses given by Valerii Fedorov at a number of places, most recently at the University of Minnesota, the Vienna of University, and the University of Economics and Business Administra tion in Vienna. It was Peter Hackl''s idea to publish these lecture notes and he took the lead in preparing and developing the text. The work continued longer than we expected, and we realized that a few thousand miles distance remains a serious hurdle even in the age of Internet and many electronic gadgets. While we mainly target graduate students in statistics, the book demands only a moderate background in calculus, matrix algebra and statistics. These are, to our knowledge, provided by almost any school in business and economics, natural sciences, or engineering. Therefore, we hope that the material may be easily understood by a relatively broad readership. The book does not try to teach recipes for the construction of experimental de signs. It rather aims at creating some understanding - and interest - in the problems and basic ideas of the theory of experimental design. Over the years, quite a number of books have been published on that subject with a varying degree of specialization. This book is organized in four chapters that layout in a rather compact form all.