Optimal Design for Nonlinear Response Models

Valerii Fedorov, PhD, is Vice President of Predictive Analytics, Innovation at Quintiles.Sergei Leonov, PhD, is a Senior Principal Scientist at AstraZeneca.

• Regression Models and Their Analysis. Convex Design Theory. Algorithms and Numerical Techniques. Optimal Design under Constraints. Nonlinear Response Models. Locally Optimal Designs in Dose Finding. Examples of Optimal Designs in PK/PD Studies. Adaptive Model-Based Designs. Other Applications of Optimal Designs. Useful Matrix Formulae. Bibliography. Index.