Vikas Pandey - Böcker

Ligands for Targeted Drug Delivery: Basic Fundamentals and Applications is a comprehensive reference focused on the many ways drug carriers can be functionalized to target specific organs, tissues, cells, and sub-cellular compartments. Chapters cover the basic concepts of targeted drug delivery, describing multiple levels of targets and challenges, along with approaches for target-specific drug delivery and a thorough overview of the challenges in design and application of ligands. Following sections discuss nanoparticles and the main ligand classes with their respective applications. The final chapters discuss future prospects of the technology and clinical aspects of ligand modified drug delivery systems.This is a key reference to drug delivery researchers dealing with the application of ligands to overcome challenges in delivering their active principles to the target structure. Biomedical engineers, materials scientists, and chemists can also benefit from the through description of ligand classes and their potential to improve drug delivery efficiency.Provides foundational information on targeted drug delivery at organ, tissue, cellular, and sub-cellular levelsCompares active and passive targeting and their applicationsSummarizes the wider classes of ligands used for drug deliveryPresents a strategic thinking framework for pairing nanocarriers with appropriate ligands for enhanced therapeutic efficacy

Metallic Nanoparticles in Cancer Therapy explores the innovative use of metallic nanoparticles in cancer therapy. It investigates the production, functionalization, and medicinal uses of metallic nanoparticles, including iron oxide, gold, and silver, emphasizing their potential for targeted drug administration, imaging, and therapy. It also tackles essential regulatory and safety considerations, connecting research with clinical application.Features:Covers specifics to the theranostic application of metallic nanoparticles for cancer treatmentDescribes therapeutic strategies of nanoparticles in drug administration routes and targeting mechanismsGives insight into phytochemical and biogenic surface-modified metal nanoparticlesDiscusses bioavailability and toxicity assessment of metallic nanoparticlesThis book is aimed at researchers in metallic nanoparticle and physicians and regulatory professionals in nanotechnology for precision oncology.

Silk represents an excellent source of natural biomaterials, and silk-based biopolymers have been used in numerous drug delivery applications. Silk has a proven track record in biomedicine owing to its superior compatibility with the human body, its superb mechanical characteristics, and its controllable propensity to decay. Due to its robust biocompatibility and its less immunogenic, non-toxic, non-carcinogenic, and biodegradable properties, silk has been widely used in biological and biomedical fields, proving to be a more efficient manner for the treatment of various diseases.This book presents a comprehensive review of silk-based biopolymer drug delivery systems, providing an introduction and going on to detail the chemistry, collection, characterization, functionalization, and numerous silk-based applications in the pharmaceutical industry and healthcare fields. It discusses its uses for oral drug delivery, for vaccine delivery systems, as natural mucoadhesive polymers for controlled drug delivery, for wound healing, etc.Exploring the many promising applications of silk-based proteins in the field of drugs and gene delivery and biomedical applications, the book emphasizes recent advancements made by academicians, researchers, and industry and regulatory scientists. It provides methodologies for the design, development, and selection of silk-based proteins in drug delivery for therapeutic applications.

This book will give an up-to-date and thorough exposition of the state of the art of concepts, design, and recent advances in nanobiotechnology-based strategies for cancer Immunotherapy, and their current and clinical status. Nanobiotechnology-based Targeted therapies and Immunotherapy have been added to the effective oncologic treatment and have become increasingly popular in oncology. It is intended to enable the researchers to prepare a variety of Nanobiotechnology-based strategies, investigate their properties, and discover their uses and applications in cancer immunotherapy.The novelty of the approach is to address an existing need to understand exhaustively the potential of the nanotechnology-based approaches, including targeted and smartly designed therapies, that deliver loaded immunoreactive (s) into the body at predefined sites. The book will also discuss the patents related to cancer immunotherapy. Because of the versatility and wide range of properties, nanobiotechnology-based systems are extensively used in cancer immunotherapy. The task of obtaining a versatile candidate in immune component(s) delivery seems to be intricated, as it has to surpass several vigorous clinical barriers. As a result, many scientists rely on nanobiotechnology-based approaches, which have already been approved and well-established. Over the years, extensive research has been undertaken on the delivery of immunoreactive(s) using nanotechnology-based delivery systems. With advancements in nanobiotechnology, more needs are realized to develop nanoengineered/smart delivery systems with even more convoluted properties. Currently, research is mainly focused on nanoengineered systems, which can perform one or more of the desired functions.The proposed book summarizes the basic principles and research supporting cancer immunotherapy clinical translation contains nanobiotechnology-based treatment strategies for all immunotherapy classes and agents, including cell-based therapies, monoclonal antibodies, cytokine therapies, checkpoint inhibitors, oncolytic viruses, adjuvant approaches, treatment combinations Includes information on all FDA-approved immunotherapies, for individual cancer types, including melanoma and other skin cancers, lung cancers, gastrointestinal cancers, hematologic cancers, genitourinary cancers, head and neck cancers, sarcomas, brain cancers, and breast cancer etc. Also explains the regulatory aspects behind the development and approval of immunotherapy drugs.

This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery.