W. Domschke – författare

These symposium papers review salient clinical as well as scientific aspects - pending or settled - of the main intestinal diseases. In particular, chapters deal with infectious and neuroendocrine diarrhoeas, coeliac sprue, allergic enteropathy, intestinal lymphomas, colorectal carcinomas, and chronic inflammatory bowel diseases, in terms of clinical presentation as well as underlying mechanisms. This book therefore aims to bridge the gaps between basic science and clinics for the eventual treatment of patients afflicted with these diseases.

In OCtober 1986, recognized authorities from a variety of disciplines met in Lisbon, Portugal, to review recent knowledge on eicosanoids - i. e., prostaglandins, throm­ boxane A , and leukotrienes - and their role in gastrointestinal diseases. 2 Briefly, in the stomach endogenous as well as exogenous prostaglandins may mediate cytoprotective actions in that they stimulate gastric mucus production, bicar­ bonate secretion and cellular regeneration while providing adequate mucosal blood flow. In contrast, thromboxane A2 by vasoconstriction may act as an ulcerogenic substance. Diarrheal states may be associated with prostaglandins of types E and F as they are capable to enhance intestinal water and electrolyte secretions. In chronic in­ flammatory bowel disease, mucosal synthesis of leukotrienes was found to be increased more markedly than that of prostaglandins suggesting that leukotrienes may have a major part in the pathogenesis of that disease. In this volume, which is an elaborated collection of the papers given on occasion of the above-mentioned symposium, the facts and problems associated with prostanoid substances are dealt with in four sections on 1. biochemistry, biology and pharmacology of eicosanoids, 2. physiologic and pathophysiologic aspects, 3. established therapeutic implications, and 4. treatment perspectives. We believe that the publication of these contributions by leading workers in the given fields provides a comprehensive and up-to-date appraisal of the role of eicosanoids in gastrointestinal diseases, and it is hoped that this volume will be of value to both basic scientists and practicing clinicians.

This volume contains a selection of papers presented at the Symposium on Operations Research 2000 (OR 2000) held at the Dresden University of Technology, September 9-12, 2000. This international Symposium was organized by the German Operations Research Society GOR in the series of its annual conferences. The Symposium had 354 participants from IS countries around the world. The 210 lectures reflected the broad spectrum of Operations Research and its interdisciplinarity, involving economics, mathematics and computer science. The volume is arranged in 14 Sections, like the conference, and a special section with the papers of the winners of the GOR Diploma Thesis award. The 86 papers have been selected by the chairpersons of the sections and the editors. Compared to previous conferences, the number of sections has been reduced by combining some overlapping sections: The former sections for linear and nonlinear programming are now contained in the 'Continuous Optimization' Section, the graph theory has been included in the 'Discrete and Combinatorial Optimization' Section.The traditional application fields are growing together in the scope of the current 'Supply Chain Management' thinking. This is considered in a corresponding section. Its high number of papers at the conference and in this volume underlines the importance of Operations Research for this modem management concept. For the first time, the conference included a section on 'Didactics of Operations Research', which found a great echo and is represented by four papers in this volume.

On the subject of stomach and gastric diseases, current cli- nical, morphological, pharmacological, biochemical as well as cellular and molecularbiological aspects will be presen- ted. The articles of the first part of this book will discuss the normal functions of the stomach (such as motility, secre- tion, tissue regeneration etc.). The second part deals with pathophysiological aspects (such as inflammation, ulceration and tumor formation) and modern possibilities of treatment. The authors aim at gaining a deeper knowledge of the sto- mach, its physiology and pathophysiology in order to use this knowledge for the better of their patients.