Wolfgang Lindner – författare

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.

This volume comprises papers from the following three workshops that were part of the complete program for the International Conference on Extending Database Technology (EDBT) held in Prague, Czech Republic, in March 2002: XML-Based Data Management (XMLDM) Second International Workshop on Multimedia Data and Document Engineering (MDDE) Young Researchers Workshop (YRWS) Together, the three workshops featured 48 high-quality papers selected from approximately 130 submissions. It was, therefore, difficult to decide on the papers that were to be accepted for presentation. We believe that the accepted papers substantially contribute to their particular fields of research. The workshops were an excellent basis for intense and highly fruitful discussions. The quality and quantity of papers show that the areas of interest for the workshops are highly active. A large number of excellent researchers are working in relevant fields producing research output that is not only of interest to other researchers but also for industry. The organizers and participants of the workshops were highly satisfied with the output. The high quality of the presenters and workshop participants contributed to the success of each workshop. The amazing environment of Prague and the location of the EDBT conference also contributed to the overall success. Last, but not least, our sincere thanks to the conference organizers – the organizing team was always willing to help and if there were things that did not work, assistance was quickly available.

This volume comprises papers from the following ?ve workshops that were part of the complete program for the International Conference on Extending Database Technology (EDBT) held in Heraklion, Greece, March 2004: • ICDE/EDBT Joint Ph. D. Workshop (PhD) • Database Technologies for Handling XML-information on the Web (DataX) • Pervasive Information Management (PIM) • Peer-to-Peer Computing and Databases (P2P&DB) • Clustering Information Over the Web (ClustWeb) Together, the ?ve workshops featured 61 high-quality papers selected from appr- imately 180 submissions. It was, therefore, dif?cult to decide on the papers that were to beacceptedforpresentation. Webelievethattheacceptedpaperssubstantiallycontribute to their particular ?elds of research. The workshops were an excellent basis for intense and highly fruitful discussions. The quality and quantity of papers show that the areas of interest for the workshops are highly active. A large number of excellent researchers are working on the aforementioned ?elds producing research output that is not only of interest for other researchers but also for industry. The organizers and participants of the workshops were highly satis?ed with the output. The high quality of the presenters and workshop participants contributed to the success of each workshop. The amazing environment of Heraklion and the location of the EDBT conference also contributed to the overall success. Last, but not least, our sincere thanks to the conference organizers – the organizing team was always willing to help and if there were things that did not work, assistance was quickly available.

This volume comprises papers from the following ?ve workshops that were part of the complete program for the International Conference on Extending Database Technology (EDBT) held in Heraklion, Greece, March 2004: • ICDE/EDBT Joint Ph. D. Workshop (PhD) • Database Technologies for Handling XML-information on the Web (DataX) • Pervasive Information Management (PIM) • Peer-to-Peer Computing and Databases (P2P&DB) • Clustering Information Over the Web (ClustWeb) Together, the ?ve workshops featured 61 high-quality papers selected from appr- imately 180 submissions. It was, therefore, dif?cult to decide on the papers that were to beacceptedforpresentation. Webelievethattheacceptedpaperssubstantiallycontribute to their particular ?elds of research. The workshops were an excellent basis for intense and highly fruitful discussions. The quality and quantity of papers show that the areas of interest for the workshops are highly active. A large number of excellent researchers are working on the aforementioned ?elds producing research output that is not only of interest for other researchers but also for industry. The organizers and participants of the workshops were highly satis?ed with the output. The high quality of the presenters and workshop participants contributed to the success of each workshop. The amazing environment of Heraklion and the location of the EDBT conference also contributed to the overall success. Last, but not least, our sincere thanks to the conference organizers – the organizing team was always willing to help and if there were things that did not work, assistance was quickly available.

This volume comprises papers from the following three workshops that were part of the complete program for the International Conference on Extending Database Technology (EDBT) held in Prague, Czech Republic, in March 2002: XML-Based Data Management (XMLDM) Second International Workshop on Multimedia Data and Document Engineering (MDDE) Young Researchers Workshop (YRWS) Together, the three workshops featured 48 high-quality papers selected from approximately 130 submissions. It was, therefore, difficult to decide on the papers that were to be accepted for presentation. We believe that the accepted papers substantially contribute to their particular fields of research. The workshops were an excellent basis for intense and highly fruitful discussions. The quality and quantity of papers show that the areas of interest for the workshops are highly active. A large number of excellent researchers are working in relevant fields producing research output that is not only of interest to other researchers but also for industry. The organizers and participants of the workshops were highly satisfied with the output. The high quality of the presenters and workshop participants contributed to the success of each workshop. The amazing environment of Prague and the location of the EDBT conference also contributed to the overall success. Last, but not least, our sincere thanks to the conference organizers – the organizing team was always willing to help and if there were things that did not work, assistance was quickly available.