This book constitutes the thoroughly refereed pChania, Crete, Greece, in May 2019. The 38 full papers presented have been carefully reviewed and selected from 52 submissions. The papers focus on advancedresearch developments in such interconnected fields as mathematical programming, global optimization, machine learning, and artificial intelligence and describe advanced ideas, technologies, methods, and applications in optimization and machine learning.

This book constitutes the thoroughly refereed pChania, Crete, Greece, in May 2019. The 38 full papers presented have been carefully reviewed and selected from 52 submissions. The papers focus on advancedresearch developments in such interconnected fields as mathematical programming, global optimization, machine learning, and artificial intelligence and describe advanced ideas, technologies, methods, and applications in optimization and machine learning.