Yong-Ku Kim – författare

This volume explores the latest techniques used to study brain function and pathophysiology of major depressive disorder (MDD), and includes suggestions of new therapeutic approaches for the treatment of MDD. The chapters into this book are organized into five parts. Part One discusses advanced approaches to studying well-established pathophysiological mechanisms. Part Two details behavioral research methods for MDD. Part Three looks at the cellular and molecular research methods for major depression, and Part Four describes the latest developments in non-invasive neuroimaging. Part Five focuses on the pharmacological and non-pharmacological interactions, including antidepressant agents and their properties, such as sexual side effects and neuroimaging biomarkers. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and comprehensive, TranslationalResearch Methods for Major Depressive Disorders is a valuable resource for researchers and scientists interested in learning more about this important and developing field. 

This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression, the clinical manifestations, and the development of more effective treatments. This second volume is devoted specifically to clinical and management issues. Readers will find detailed information on a wide range of frequently encountered and more complicated clinical presentations, with examination of risk factors and links to other conditions. Diagnostic aspects, including progress toward biological classification and the role of neuroimaging, are explored. Current trends in therapy are examined at length, drawing on the latest evidence and covering not only antidepressant medications but also the roles of neurostimulation, combined pharmacotherapy and psychotherapy, mindfulness-based cognitive therapy, and complementary and alternative medicine. The companion volume is dedicated to the underlying biomedical and neurobiological basis of depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.

This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression.The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer''s disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

This book reviews all important aspects of anxiety disorders with the aim of shedding new light on these disorders through combined understanding of traditional and novel paradigms. The book is divided into five sections, the first of which reinterprets anxiety from a network science perspective, examining the altered topological properties of brain networks in anxiety disorders. The second section discusses recent advances in understanding of the neurobiology of anxiety disorders, covering, for example, gene-environmental interactions and the roles of neurotransmitter systems and the oxytocin system. A wide range of diagnostic and clinical issues in anxiety disorders are then addressed, before turning attention to contemporary treatment approaches in the context of novel bio-psychosocial-behavioral models, including bio- and neurofeedback, cognitive behavioral therapy, neurostimulation, virtual reality exposure therapy, pharmacological interventions, psychodynamictherapy, and CAM options. The final section is devoted to precision psychiatry in anxiety disorders, an increasingly important area as we move toward personalized treatment.

Anxiety Disorders will be of interest for all researchers and clinicians in the field.

This book reviews all aspects of major depressive disorder (MDD), casting light on its neurobiological underpinnings and describing the most recent advances in management. The book is divided into four sections, the first of which discusses MDD from a network science perspective, highlighting the alterations in functional and structural connectivity and presenting insights achieved through resting state functional MRI and the development of neuroimaging-based biomarkers. The second section examines important diagnostic and neurobiological issues, while the third considers the currently available specific treatments for MDD, including biofeedback, neurofeedback, cognitive behavioral therapy, acceptance and commitment therapy, neuromodulation therapy, psychodynamic therapy, and complementary and alternative medicine. A concluding section is devoted to promising emerging treatments, from novel psychopharmacological therapies through to virtual reality treatment, immunotherapy, biomarker-guided tailored therapy, and more. Written by leading experts from across the world, the book will be an excellent source of information for both researchers and practitioners.