This book focuses on contemporary issues and dilemmas in relation to depression. The aim of the book is equip readers with an up-to-date understanding of the clinical and neurobiological underpinning of depression, the clinical manifestations, and the development of more effective treatments.The book is divided into four sections, the first of which discusses conceptual and diagnostic issues in major depression, highlighting current criticism and future perspective on DSM-5, biological classification, neural circuit taxonomy. The Second section considers symptomatic and clinical issue in major depression, including anhedonia, cognition, pain, suicide, obesity and gender difference. The Third examines important etiological and neurobiological issues, including epigenetics, genetics, HPA axis, neuroimaging, and gut-brain axis. A concluding section is devoted to current therapeutic issues in major depression, focusing new antidepressant, psychedelics, neurostimulation, digital therapy, and personalized integrative treatment.Understanding Depression is an indispensable resource for psychiatrists, neurologists, pharmacologists, medical researchers and graduate students engaged in affective neuroscience and clinical psychiatry.

This book focuses on contemporary issues and dilemmas in relation to depression. The aim of the book is equip readers with an up-to-date understanding of the clinical and neurobiological underpinning of depression, the clinical manifestations, and the development of more effective treatments.The book is divided into four sections, the first of which discusses conceptual and diagnostic issues in major depression, highlighting current criticism and future perspective on DSM-5, biological classification, neural circuit taxonomy. The Second section considers symptomatic and clinical issue in major depression, including anhedonia, cognition, pain, suicide, obesity and gender difference. The Third examines important etiological and neurobiological issues, including epigenetics, genetics, HPA axis, neuroimaging, and gut-brain axis. A concluding section is devoted to current therapeutic issues in major depression, focusing new antidepressant, psychedelics, neurostimulation, digital therapy, and personalized integrative treatment.Understanding Depression is an indispensable resource for psychiatrists, neurologists, pharmacologists, medical researchers and graduate students engaged in affective neuroscience and clinical psychiatry.