Yury V. Kistenev - Böcker

This book focuses on machine-learning medical applications based on molecular spectroscopy and molecular imaging data. Written with specialists in biomedical optics, laser spectroscopy, bioengineering, and medical engineering in mind, the chapters cover topics such as biomarker conception, molecular laser imaging, and artificial intelligence; laser-based molecular-data-acquisition technologies; feature selection and extraction methods; unsupervised and supervised approaches; and in vivo non-invasive diagnostics using laser molecular spectroscopy and imaging combined with machine learning. Sample datasets and Python modules are provided as supplemental materials for the most useful algorithms.

This book focuses on polarization microscopy, a powerful optical tool used to study anisotropic properties in biomolecules, and its enormous potential to improve diagnostic tools for various biomedical research. The interaction of polarized light with normal and abnormal regions of tissue reveals structural information associated with its pathological condition. Diagnosis using conventional microscopy can be time-consuming, as pathologists require an hour to freeze and stain tissue slices from suspected patients. In comparison, polarization microscopy more quickly distinguishes abnormal tissue and provides better microstructural information of samples, even in the absence of staining. This book provides a basic understanding of the properties of polarized light, a description of the polarization microscope, and a mathematical formalism of Mueller matrix polarimetry. The authors discuss various advanced linear and nonlinear optical techniques such as optical coherence tomography (OCT), reflectance and transmission spectroscopy, fluorescence, multiphoton excitation, second harmonic generation, Raman microscopy, and more. They explore the exciting potential of integrating polarimetry with these techniques for possible applications in different areas of biomedical research, as well as the associated challenges. Including the most recent developments on the topic, this book serves as a modern guide to polarization microscopy and advancements in its use in biomedical research.

This book focuses on polarization microscopy, a powerful optical tool used to study anisotropic properties in biomolecules, and its enormous potential to improve diagnostic tools for various biomedical research.

The book reviews the recent developments in brain imaging and their technological advancements to understand molecular mechanisms associated with neurological disorders and basic behaviors in humans and rodents at the structural, molecular, and functional levels.