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5 produkter
365 kr
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230 kr
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Del 2 - Icp Selected Papers
Selected Papers Of Denis Noble Cbe Frs, The: A Journey In Physiology Towards Enlightenment
Inbunden, Engelska, 2012
3 258 kr
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This is a scientific and philosophical autobiography written around a collection of Denis Noble's most significant papers. It traces a remarkable journey from naïve reductionism to a rigorous systems approach to living systems. It is rigorous because Denis Noble was one of the first biologists to construct computer models of cells and organs of the body. His theoretical work is entirely mathematically based, with no room for ambiguity. Far from the denigration of the systems approach as holistic ‘hand-waving’, his work is now regarded by pharmaceutical companies and regulators as the gold standard of modelling in the development of new medication.Systems Biology is an idea in search of a definition. This book explains why this is true: it is an approach rather than a subject. Denis Noble's work is one of the clearest examples of the systems approach in practice since it reveals the nature of some of the forms of downward causation in multilevel analysis. The story will delight readers who like to see how scientific controversy is resolved, since many of the developments described in each chapter were highly controversial when they occurred.
909 kr
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1 146 kr
Tillfälligt slut
Metabonomics - defined as the quantitative measurement of the multiparametric, time-related metabolic responses of a complex (multicellular) system to a pathophysiological intervention or genetic modification - is an effective tool for toxicological studies, potential biomarker identification of diseases, and identification of regulatory network pathways in plants and animals. Metabonomics is discussed in detail in many applications such as drug development, disease treatment and modernization of traditional Chinese medicine. This book covers research on metabonomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation.The authors have been directly involved in the development of all the subject areas, including gas chromatography, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Basic definition, breakthrough achievements and the future of metabonomic studies are described, making this book a valuable source for researchers in metabonomics in diverse fields such as animal, cellular, microbial, pharmaceutical, medical, and life sciences.