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In the next millennium, it is anticipated that human factors issues will take centre stage in initiatives targeted at enhancing economic competitiveness and productivity. This development is already discernible in nascent knowledge and digital based industries and economies, which are expected to emerge in force in the near future and continue to dominate thereafter. These developments will establish irreversibly the emerging global economy. The theme of the APCHI 2000 conference is: "Towards a seamless integration of collaborative human computer systems" to reflect the already discernible shift in focus of human computer interaction (HCI). whilst the theme of the ASEAN Ergonomics 2000 conference is: "From user centeredness to people centeredness" to reflect the imminent shift in focus that is required of human factors.

The papers in these proceedings provide a good contrast of human factors contributions to both old and new economies that make up ASEAN and APEC. They highlight the diverse roles human factors can play in advancing the quality of life in developed, developing and third world nations. They also serve as a guide to human factors practitioners in old economies on what to expect as their economies develop.

This publication on HHV-6 is the first and so far only one where a composite picture of the virus is presented. Comprehensive accounts of HHV-6 biology, molecular virology, epidemiology and their association with diseases, including the effects of antiviral drugs, are covered in chapters contributed by leading researchers on HHV-6. The book is an excellent source of reference on HHV-6 for basic researchers, diagnostic virologists, clinicians, medical students and medical librarians since it provides the most current state-of-the-art information on HHV-6.

Local interstitial radiation therapy of intrinsic and inaccessible brain tumors is confronted with two major problems: 1. The tolerance of normal brain tissue, which is usually involved in local tumor irradiation, i.e. perifocal white matter edema and demyelinating effects, is crucial. 2. Data on radiation effects of implanted radioactive sources on neoplastic tissue, i.e. data on the radiosensitivity and on the biology of tumors, are still widely unavailable. In clinical practice the dose with which to achieve a given volume of tumor necrosis is roughly estimated. This report deals with the experimental findings of Iodine-125 and Iridium-I92 permanent implants in healthy and neoplastic brain tissue. Our own experimental findings are correlated with experimental data on Yttnul11-l)O irradiation from the literature. The study is directed to collect data on the tolerance non-tumoral brain tissue and to attempt to establish a dose-response relationship. Morphologic Changes in the Dog Brain Following Interstitial Iodine-125 Irradiation Iodine-I25 seeds (manufactured by 3 M Company, St. Paul, M. N.) with an activity of 3.55 mCi were permanently implanted under stereotactic conditions into the subcortical white matter of the gyrus coronalis of the left hemisphere in 6 beagle dogs. One animal with a non-radioactive seed implanted under similar operative conditions served as a control. The animals were allowed to survive 25, 46, 71, 94, 248, 368 days, respectively, after the implantation. The control animal survived 46 days. A detailed description of the experimental procedure is given elsewhere 16. 17.

In 1982 Berlin was host for the second time to the International Symposium on Atherosclerosis. In 1973 the third symposium was held there, following the first in Athens -opened by the unforgettable Paul D. White -and the second in Chicago, where the great gentlemen of atherosclerosis research - Louis Katz and Irving Page - left their special imprint on the meeting. Since the third symposium in Berlin impressive advances have been made in the field of atherosclerosis. The symposia in Tokyo in 1976 and in Houston in 1979 introduced important new knowledge from current research, stimulating worldwide interest; Berlin highlighted the latest developments. The International Atherosclerosis Society (lAS) provides an international forum for the entire field of atherosclerosis research. Its main purpose is to apply the results of basic research to clinical medicine, and thereby to benefit the practitioner. Prevention and rehabilitation are of special importance. Intensified international cooperation is urgently needed at all levels. A declared goal of the lAS is contact between young investigators and between international research and work groups. Participating in the Berlin meeting were 1400 researchers from 42 nations. This illustrates the growing interest in atherosclerosis as the leading cause of death in "developed" societies. However, the incidence of atherosclerosis is increasing worldwide, although there are national differences in the pattern and appearance of the disease; this was documented at the Berlin Symposium.

In 1982 Berlin was host for the second time to the International Symposium on Atherosclerosis. In 1973 the third symposium was held there, following the first in Athens -opened by the unforgettable Paul D. White -and the second in Chicago, where the great gentlemen of atherosclerosis research - Louis Katz and Irving Page - left their special imprint on the meeting. Since the third symposium in Berlin impressive advances have been made in the field of atherosclerosis. The symposia in Tokyo in 1976 and in Houston in 1979 introduced important new knowledge from current research, stimulating worldwide interest; Berlin highlighted the latest developments. The International Atherosclerosis Society (lAS) provides an international forum for the entire field of atherosclerosis research. Its main purpose is to apply the results of basic research to clinical medicine, and thereby to benefit the practitioner. Prevention and rehabilitation are of special importance. Intensified international cooperation is urgently needed at all levels. A declared goal of the lAS is contact between young investigators and between international research and work groups. Participating in the Berlin meeting were 1400 researchers from 42 nations. This illustrates the growing interest in atherosclerosis as the leading cause of death in "developed" societies. However, the incidence of atherosclerosis is increasing worldwide, although there are national differences in the pattern and appearance of the disease; this was documented at the Berlin Symposium.

Local interstitial radiation therapy of intrinsic and inaccessible brain tumors is confronted with two major problems: 1. The tolerance of normal brain tissue, which is usually involved in local tumor irradiation, i.e. perifocal white matter edema and demyelinating effects, is crucial. 2. Data on radiation effects of implanted radioactive sources on neoplastic tissue, i.e. data on the radiosensitivity and on the biology of tumors, are still widely unavailable. In clinical practice the dose with which to achieve a given volume of tumor necrosis is roughly estimated. This report deals with the experimental findings of Iodine-125 and Iridium-I92 permanent implants in healthy and neoplastic brain tissue. Our own experimental findings are correlated with experimental data on Yttnul11-l)O irradiation from the literature. The study is directed to collect data on the tolerance non-tumoral brain tissue and to attempt to establish a dose-response relationship. Morphologic Changes in the Dog Brain Following Interstitial Iodine-125 Irradiation Iodine-I25 seeds (manufactured by 3 M Company, St. Paul, M. N.) with an activity of 3.55 mCi were permanently implanted under stereotactic conditions into the subcortical white matter of the gyrus coronalis of the left hemisphere in 6 beagle dogs. One animal with a non-radioactive seed implanted under similar operative conditions served as a control. The animals were allowed to survive 25, 46, 71, 94, 248, 368 days, respectively, after the implantation. The control animal survived 46 days. A detailed description of the experimental procedure is given elsewhere 16. 17.

This book is Volume 2 of the EUROCK 2018 proceedings. Geomechanics and Geodynamics of Rock Masses contains contributions presented at EUROCK 2018, the 2018 International Symposium of the International Society for Rock Mechanics (ISRM 2018, Saint Petersburg, Russia, 22-26 May 2018). Dedicated to recent advances and achievements in the fields of geomechanics and geotechnology, the main topics of the book include:- Physical and mechanical properties of fractured rock (laboratory testing and rock properties, field measurements and site investigations)- Geophysics in rock mechanics- Rock mass strength and failure- Nonlinear problems in rock mechanics- Effect of joint water on the behavior of rock foundation- Numerical modeling and back analysis- Mineral resources development: methods and rock mechanics problems- Rock mechanics and underground construction in mining, hydropower industry and civil engineering- Rock mechanics in petroleum engineering- Geodynamics and monitoring of rock mass behavior- Risks and hazards- Geomechanics of technogenic depositsGeomechanics and Geodynamics of Rock Masses will be of interest to researchers and professionals involved in the various branches of rock mechanics and rock engineering. EUROCK 2018, organized by the Saint Petersburg Mining University, is a continuation of the successful series of ISRM symposia in Europe, which began in 1992 in Chester, UK.

This deluxe compendium features sumptuous photography from the making of HBO’s unparalleled hit show Game of Thrones. Offering a rare peek behind the scenes of one of the most popular and revered television shows of all time, The Photography of Game of Thrones gives fans an exclusive look at some of their favorite characters and moments from the show in gorgeous detail.The official principal Game of Thrones unit photographer, Helen Sloan, has compiled the most iconic shots from the acclaimed show. The best of her collection, along with the work of the unit photography team, is featured here. Bold and gorgeously crafted, The Photography of Game of Thrones captures in striking detail the scope and nuance of the show, celebrating a world of iconic characters, shocking moments, breathtaking locations, and much more.

Geomechanics and Geodynamics of Rock Masses – Selected Papers contains selected contributions from EUROCK 2018, the 2018 International Symposium of the International Society for Rock Mechanics (ISRM 2018, Saint Petersburg, Russia, 22—26 May 2018). Dedicated to recent advances and achievements in the fields of geomechanics and geotechnology, the book will be of interest to researchers and professionals involved in the various branches of rock mechanics and rock engineering. EUROCK 2018, organized by the Saint Petersburg Mining University, is a continuation of the successful series of ISRM symposia in Europe, which began in 1992 in Chester, UK.

A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights.

The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells.

Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

Prevention of Accidents at Work collects papers presented at the 9th International Conference on the Prevention of Accidents at Work (WOS 2017) held in Prague, Czech Republic, on October 3-6, 2017, organized by the VSB-Technical University of Ostrava. The conference on current issues within occupational safety is organized under the umbrella of Workingonsafety.net (WOS.net). WOS.net is an international network of decision-makers, researchers and professionals responsible for the prevention of accidents and trauma at work. The network aims to bring accident prevention experts together in order to facilitate the exchange of experience, new findings and best practices between different countries and sectors. WOS.net is supported by the European Agency for Safety and Health at Work (EU-OSHA).The overall theme is safety management complexity in a changing society, with the motto: Do we need a holistic approach? Underlying topics include: Foundations of safety science: theories, principles, methods and tools; Research to practice: achievements, lessons learned and challenges; Risk management and safety culture: case studies, best practices and further needs; Safety regulation: reasonable practicable approach; Education and training: prerequisite for safety; Complexity and safety: multidisciplinarity and inter-stakeholder views. Prevention of Accidents at Work should be valuable to researchers, policy makers, safety professionals, labor inspectors, labor administrators and other experts in the prevention of occupational accidents.

Occupational Safety and Hygiene VI collects recent papers of selected authors from 21 countries in the domain of occupational safety and hygiene (OSH). The contributions cover a wide range of topics, including:- Occupational safety- Risk assessment- Safety management- Ergonomics- Management systems- Environmental ergonomics- Physical environment- Construction safety, and- Human factorsOccupational Safety and Hygiene VI represents the state-of-the-art on the above mentioned domains, and is based on research carried out at universities and other research institutions. Some contributions focus more on practical case studies developed by OSH practitioners within their own companies. Hence, the book provides practical tools and approaches currently used by OHS practitioners in a global context.

The International Committee on Large Dams (ICOLD) held its 26th International Congress in Vienna, Austria (1-7 July 2018). The proceedings of the congress focus on four main questions: 1. Reservoir sedimentation and sustainable development; 2. Safety and risk analysis; 3. Geology and dams, and 4. Small dams and levees. The book thoroughly discusses these questions and is indispensable for academics, engineers and professionals involved or interested in engineering, hydraulic engineering and related disciplines.

By the late 1810s, a global revolution in cotton had remade the U.S.-Mexico border, bringing wealth and waves of Americans to the Gulf Coast while also devastating the lives and villages of Mexicans in Texas. In response, Mexico threw open its northern territories to American farmers in hopes that cotton could bring prosperity to the region. Thousands of Anglo-Americans poured into Texas, but their insistence that slavery accompany them sparked pitched battles across Mexico. An extraordinary alliance of Anglos and Mexicans in Texas came together to defend slavery against abolitionists in the Mexican government, beginning a series of fights that culminated in the Texas Revolution. In the aftermath, Anglo-Americans rebuilt the Texas borderlands into the most unlikely creation: the first fully committed slaveholders' republic in North America. Seeds of Empire tells the remarkable story of how the cotton revolution of the early nineteenth century transformed northeastern Mexico into the western edge of the United States, and how the rise and spectacular collapse of the Republic of Texas as a nation built on cotton and slavery proved to be a blueprint for the Confederacy of the 1860s.

Operation KE explores the air combat that attended the Japanese evacuation of Guadalcanal in early 1943 -a topic which has hitherto received very little attention. Operation KE was successful largely because Japanese strategic planning and tactical execution was basically sound. The traditional view holds that the Japanese got away with the initiative largely because the Americans let them; the US Pacific high command felt it was not worth the effort to try and stop them. Letourneau contends that this was not entirely the case. He argues that the Cactus Air Force and Guadalcanal-based naval units did their best to disrupt the evacuation, still believing that the Tokyo Express was bringing reinforcements and supplies to the 17th Army. Other US forces in the South Pacific did make a half-hearted and questionably-executed attempt to stop the Japanese, but were bluffed into adopting a wait-and-see posture.Operation KE focuses on the air war fought between the Cactus and US 13th Air Forces on the one hand and the Japanese Navy and Army Air Forces on the other, from mid-December, 1942 to mid-February, 1943. The book scrutinizes the US air strikes against the six KE-related Tokyo Express destroyer runs, plus related air strikes against the Japanese merchant marine, as well as air and naval base-suppression missions undertaken by both sides, to determine what actually happened in order to analyze why the Japanese evacuation succeeded and why Cactus failed to stop it.Background chapters attempt to assess the respective states of readiness of the Japanese and US air arms in the South Pacific to support on the one hand and counter on the other the execution of Operation KE. The central portion of the book narrates in some detail what actually occurred in the air and at sea --including air strikes, fighter sweeps, base suppression missions, and naval sorties --during the crucial prelude to and the actual playing out of the interrelated events that comprised the evacuation operation. Concluding chapters analyze, on both strategic and tactical levels, the Japanese planning and execution of Operation KE, and Cactus' initiatives to interdict KE's successful prosecution. The authors conclude that both the Japanese and the American states of readiness on the eve of Operation KE suffered in such matters as optimizing both resources and operating procedures, and combating a hostile environment. Consequently, both combatants were somewhat handicapped in their abilities respectively to carry out and contest Operation KE.The authors contend that the Japanese developed a reasonably sound strategy that exploited those methods and tools of war then in use in the South Pacific; to achieve success, they maximized their own strengths while taking advantage of their adversary's limitations. Contrary to the traditional view, the authors are of the opinion that Japanese utilization of their newly-built airstrip at Munda in the Central Solomons played an important role in the success of Operation KE, which was in keeping with the long-range intention of developing Munda and Vila airstrips as major forward airbases to defend against any Allied push toward Rabaul through the Solomons.​The U.S., on the other hand, by consistently misreading Japanese intent regarding Operation KE and pursuing a cautious offensive strategy, blunted the tactical impact of their initiatives to counter the evacuation. Several imprudent tactical decisions and a misallocation of resources further diluted the strength of US efforts.