Biology of Aging and its Modulation - Böcker

After decades of systematic collection of data describing age-related changes in organisms, organs, tissues, cells and macromolecules, biogerontologists are now in a position to construct general principles of ageing and explore various possibilities of intervention using rational approaches. While not giving serious consideration to the claims made by charlatans, it cannot be ignored that several researchers are making genuine attempts to test and develop various means of intervention for the prevention and treatment of age-related diseases, for regaining the functional abilities and for prolonging the lifespan of experimental organisms. This book provides up-to-date information and an evaluation of a variety of approaches being tried for modulating ageing and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. The goal of research on ageing is not to increase human longevity regardless of the consequences, but to increase active longevity free from disability and functional dependence.

This title provides updated knowledge on the basic features and mechanisms of cellular ageing. Contributions consider genetic and environmental factors, failure of genetic and cellular repair mechanisms, and the epigenetic modifications that determine the final lifespan of cells. The book also provides an understanding on how aging mechanisms in mice, a most frequently used model, differ with that of humans who receive better tumour surveillance because of stringent controls on ageing mechanisms. It also appraises the use of modern technology for ageing studies and its intervention. This book serves as an excellent reading on cellular ageing for undergraduate students, researchers and experts of this area.

This volume is devoted to aging at the organismic level. Different levels of organisation, ranging from single cell organisms (yeast) to humans are included. In addition to the currently most important model systems like yeast, filamentous fungi, Caenorabditis elegans, flies and mice other systems like sponges and plants are discussed. Most importantly, research using different aging models can be expected to unravel the most important basic mechanisms of aging that are conserved in all species. In addition, a critical discussion of what can be expected from this kind of strategy for the understanding of aging in humans is included.

Since the early 1960s, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. "Aging at the Molecular Level" examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume should be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.

During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. This volume on "Aging of Organs and Systems", is an attempt to bring understanding to both the aging process and the disease processes of old age.

After decades of systematic collection of data describing age-related changes in organisms, organs, tissues, cells and macromolecules, biogerontologists are now in a position to construct general principles of ageing and explore various possibilities of intervention using rational approaches. While not giving serious consideration to the claims made by charlatans, it cannot be ignored that several researchers are making genuine attempts to test and develop various means of intervention for the prevention and treatment of age-related diseases, for regaining the functional abilities and for prolonging the lifespan of experimental organisms. This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. The goal of research on ageing is not to increase human longevity regardless of the consequences, but to increase active longevity free from disability and functional dependence.

This book provides updated knowledge on the basic features and mechanisms of cellular aging established since its first manifestation at cellular level 40 years ago. Contributions of genetic and environmental factors, failure of genetic and cellular repair mechanisms, and the epigenetic modifications determine the final lifespan of cells. This book also provides an understanding on how aging mechanisms in mice, a most frequently used model, differ with that of humans who receive better tumor surveillance because of stringent controls on aging mechanisms. It also appraises the use of modern technology for aging studies and its intervention. This book serves as an excellent reading on cellular aging for undergraduate students, researchers and experts of this area.

This Volume of the Series is devoted to aging at the organismic level. Different levels of organisation, ranging from single cell organisms (yeast) to humans are included. In addition to the currently most important model systems like yeast, filamentous fungi, Caenorabditis elegans, flies and mice, other systems like sponges and plants are discussed. Most importantly, research using different aging models can be expected to unravel the most important basic mechanisms of aging that are conserved in all species. In addition, a critical discussion of what can be expected from this kind of strategy for the understanding of aging in humans is included. This book serves as excellent reading for graduate students, scientists in Medical Research, Medical doctors, researchers in pharmacological fields, researchers, biologists, and experts of this area.

During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.