From the reviews: "This volume is the first in a series of five in which the biology of ageing will be explored. ... Altogether, this is a fairly comprehensive coverage of the current themes at the molecular level, with the further areas to be explored being well highlighted. The chapters are well-referenced and this timely text will be especially useful to those workers entering the field." (P.B.Gahan, Cell Biochemistry & Function, Vol. 23 (5), 2005)

• 1. Free radical production and antioxidant defense: a primer.- 2. Oxidative DNA damage and repair — implications for aging.- 3. Oxidative damage to proteins.- 4. Ageing rate, mitochondrial free radical production and constitutive sensitivity to lipid peroxidation: insights from comparative studies.- 5. Genomic instability in human premature aging.- 6. Oxidative damage, somatic mutations and cellular aging.- 7. Mitochondria and aging.- 8. Biological clocks in the aging cell.- 9. Telomeric damage in aging.- 10. Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice.- 11. Non-oxidative modification of DNA and proteins.- 12. Transcriptional and translational dysregulation during aging.- 13. Metabolic regulation of gene silencing and life span.- 14. The proteasome in aging.- 15. Aging and lysosomal degradation of cellular constituents.

From the reviews: "This volume is the first in a series of five in which the biology of ageing will be explored. ... Altogether, this is a fairly comprehensive coverage of the current themes at the molecular level, with the further areas to be explored being well highlighted. The chapters are well-referenced and this timely text will be especially useful to those workers entering the field." (P.B.Gahan, Cell Biochemistry & Function, Vol. 23 (5), 2005)

• 1. Free radical production and antioxidant defense: a primer.- 2. Oxidative DNA damage and repair — implications for aging.- 3. Oxidative damage to proteins.- 4. Ageing rate, mitochondrial free radical production and constitutive sensitivity to lipid peroxidation: insights from comparative studies.- 5. Genomic instability in human premature aging.- 6. Oxidative damage, somatic mutations and cellular aging.- 7. Mitochondria and aging.- 8. Biological clocks in the aging cell.- 9. Telomeric damage in aging.- 10. Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice.- 11. Non-oxidative modification of DNA and proteins.- 12. Transcriptional and translational dysregulation during aging.- 13. Metabolic regulation of gene silencing and life span.- 14. The proteasome in aging.- 15. Aging and lysosomal degradation of cellular constituents.

From the reviews: "This volume is the first in a series of five in which the biology of ageing will be explored. ... Altogether, this is a fairly comprehensive coverage of the current themes at the molecular level, with the further areas to be explored being well highlighted. The chapters are well-referenced and this timely text will be especially useful to those workers entering the field." (P.B.Gahan, Cell Biochemistry & Function, Vol. 23 (5), 2005)

• 1. Free radical production and antioxidant defense: a primer.- 2. Oxidative DNA damage and repair — implications for aging.- 3. Oxidative damage to proteins.- 4. Ageing rate, mitochondrial free radical production and constitutive sensitivity to lipid peroxidation: insights from comparative studies.- 5. Genomic instability in human premature aging.- 6. Oxidative damage, somatic mutations and cellular aging.- 7. Mitochondria and aging.- 8. Biological clocks in the aging cell.- 9. Telomeric damage in aging.- 10. Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice.- 11. Non-oxidative modification of DNA and proteins.- 12. Transcriptional and translational dysregulation during aging.- 13. Metabolic regulation of gene silencing and life span.- 14. The proteasome in aging.- 15. Aging and lysosomal degradation of cellular constituents.