Birkhäuser Advances in Infectious Diseases – serie

Chagas disease is a potentially life threatening condition that was historically mainly endemic to Latin America. Over the last decade, however, the disease has spread to and is increasingly prevalent in other continents such as North America and Europe, with an estimated 7 million people infected worldwide. It is primarily transmitted by insect vectors that carry the parasite Trypanosoma cruzi, the disease agent. In areas where there is vector control and in non-endemic countries, it is mainly transmitted via congenital infection. Cardiac and gastrointestinal complications are common in untreated individuals.This book offers a comprehensive overview of Chagas disease, including its vectorial and congenital transmission, and molecular diagnosis, which is essential for screening, and developing and providing timely, effective anti-trypanosomal treatment. Written by experts working with infected patients on a daily basis, it discusses the pathogenesis of congenital, cardiac, gastrointestinal and oral Chagas disease, as well as its treatment and the pharmacological aspects of drug development in this area.Chapter "Chagas Disease Treatment Efficacy Biomarkers: Myths and Realities" is available open access under a via link.springer.com.

This book provides deep insights into the ecology of the plague bacterium Yersinia pestis in natural foci, its diversity, genetic variability and the function of the vector, thus painting a holistic picture of how plague pandemics have evolved and how the bacterium has adapted perfectly to its environment over such a long period of time. The book reviews studies of several generations of scientists from the countries of the former Soviet Union where plague foci are found and presents them for the first time to a global audience. In addition, the book provides comprehensive information on historical plague pandemics and explores future strategies for managing the disease.

This book provides deep insights into the ecology of the plague bacterium Yersinia pestis in natural foci, its diversity, genetic variability and the function of the vector, thus painting a holistic picture of how plague pandemics have evolved and how the bacterium has adapted perfectly to its environment over such a long period of time. The book reviews studies of several generations of scientists from the countries of the former Soviet Union where plague foci are found and presents them for the first time to a global audience. In addition, the book provides comprehensive information on historical plague pandemics and explores future strategies for managing the disease.

This book subtly presents the Peste des Petits Ruminants Virus (PPRV), a morbillivirus closely related to rinderpest virus, that decimates sheep and goats along with those of other susceptible domestic ruminants and many wildlife species. Following its first introduction to the West Africa in 1940, PPRV was rapidly disseminated across sub-Saharan Africa, the Middle East and Southern Asia. Recent outbreaks of PPR in Morocco and European part of Turkey are posing continuous threats to many European countries.This book focuses on the key dynamics of this deadly disease, and incorporates considerable historical detail, infection biology, comparative molecular biology, and pathophysiology of the disease. The accurate disease diagnosis, management, and prevention of the disease are crucial for clinicians. Thus, three chapters emphasize the traditional prophylactic measures, clinical outcome of the disease and clinical disease assessments. The genomic organization and molecularbiology of PPRV is described comprehensively. Because of the current sensitivity about an emergence of PPRV and successful Global Rinderpest Eradication Programme, finally a chapter is dedicated to explore the possibilities to control and eradicate the PPRV from the globe, the way similar to rinderpest virus. Collectively, this book consists of high quality scientific and historical research contributed by the top experts in the field, from all around the globe. Moreover, editor’s vast experience with PPRV and collaborations with other researchers worldwide make this book unique.This book offers a valuable reference source for virologists, field veterinarians, infection and molecular biologists, immunologists, scientists in related fields and veterinary school libraries.

This book subtly presents the Peste des Petits Ruminants Virus (PPRV), a morbillivirus closely related to rinderpest virus, that decimates sheep and goats along with those of other susceptible domestic ruminants and many wildlife species. Following its first introduction to the West Africa in 1940, PPRV was rapidly disseminated across sub-Saharan Africa, the Middle East and Southern Asia. Recent outbreaks of PPR in Morocco and European part of Turkey are posing continuous threats to many European countries.This book focuses on the key dynamics of this deadly disease, and incorporates considerable historical detail, infection biology, comparative molecular biology, and pathophysiology of the disease. The accurate disease diagnosis, management, and prevention of the disease are crucial for clinicians. Thus, three chapters emphasize the traditional prophylactic measures, clinical outcome of the disease and clinical disease assessments. The genomic organization and molecularbiology of PPRV is described comprehensively. Because of the current sensitivity about an emergence of PPRV and successful Global Rinderpest Eradication Programme, finally a chapter is dedicated to explore the possibilities to control and eradicate the PPRV from the globe, the way similar to rinderpest virus. Collectively, this book consists of high quality scientific and historical research contributed by the top experts in the field, from all around the globe. Moreover, editor’s vast experience with PPRV and collaborations with other researchers worldwide make this book unique.This book offers a valuable reference source for virologists, field veterinarians, infection and molecular biologists, immunologists, scientists in related fields and veterinary school libraries.

As individuals age, their ability to respond to and clear pathogens and to control unwanted immune reactions declines, leading to a greater incidence of certain infectious diseases, autoimmunity and general immune dysfunctions. Most remarkably, the efficacy of vaccines is frequently decreased in elderly persons. Therefore, age-associated dysfunctions of the humoral and cellular immune responses have a strong clinical impact. Improving our understanding of the aged immune system is crucial in developing effective prevention and treatment programs that will facilitate healthy aging and improve the quality of life of the elderly population.The aim of this volume is to summarize current knowledge on the cellular and molecular aspects of the aging immune system, with an emphasis on infectious diseases and new therapeutic approaches.

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines.This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.

The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines.This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.

The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.

Viral infections of the nervous system are important because they are associated with high morbidity and mortality. A variety of pathogenetic mechanisms are involved in these infections and an understanding of the pathogenesis is essential in understanding the diagnostic and clinical management aspects of the disease. Specialized investigations are often necessary for definitive diagnosis, although a presumptive diagnosis should often be suspected on the basis of the clinical features. Many of the chapters in this book are written by neurologists who are experts in basic science research of their topic in addition to active clinical practice in their specialty.

Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated “immune-privileged sites” by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms. This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.

Viral infections of the nervous system are important because they are associated with high morbidity and mortality. A variety of pathogenetic mechanisms are involved in these infections and an understanding of the pathogenesis is essential in understanding the diagnostic and clinical management aspects of the disease. Specialized investigations are often necessary for definitive diagnosis, although a presumptive diagnosis should often be suspected on the basis of the clinical features. Many of the chapters in this book are written by neurologists who are experts in basic science research of their topic in addition to active clinical practice in their specialty.

As individuals age, their ability to respond to and clear pathogens and to control unwanted immune reactions declines, leading to a greater incidence of certain infectious diseases, autoimmunity and general immune dysfunctions. Most remarkably, the efficacy of vaccines is frequently decreased in elderly persons. Therefore, age-associated dysfunctions of the humoral and cellular immune responses have a strong clinical impact. Improving our understanding of the aged immune system is crucial in developing effective prevention and treatment programs that will facilitate healthy aging and improve the quality of life of the elderly population.The aim of this volume is to summarize current knowledge on the cellular and molecular aspects of the aging immune system, with an emphasis on infectious diseases and new therapeutic approaches.

Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated “immune-privileged sites” by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms. This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.

This book provides a useful text for research students and scientists on the latest knowledge about the immune system of fish, cutting edge technologies and the step required to develop, test and commercialise fish vaccines. It brings together information that is currently difficult to obtain in one book, and highlights problem areas and research topics that still need to be addressed to improve future vaccines.

This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host healthy and preventing infectious diseases. The first chapters deal with several examples of the role of AMP in different epithelial organs (skin and wound healing, eye, lung, genito-urinary tract, gut), which are exposed to different kinds of infectious microorganisms and as a result produce different patterns of AMP. Examples of the dysregulation of AMP expression and function promoting infections are discussed. The capacity of AMP to restrict the availability of essential metals to bacteria as an efficient antibacterial strategy in nutritional immunity is discussed in the next chapter. Our current understanding of how vitamin D, the sunshine vitamin, influences AMP-expression and how this can affect our health is also addressed. Last but not least, the role of AMP in HIV infection and the immunomodulatory properties of AMP highlight the diverse facets of AMP in host immunity. AMP’s specific functions, including in fighting multi-resistant bacteria, suggest that they may offer therapeutic benefits – a question that is discussed in the final chapter.

Allergy is developing into one of the most prevalent diseases affecting individuals in the very early days of life. While the cause of this epidemic is still unclear, it appears that the westernized life style is playing an important role, which includes nutrition, possibly air pollution as well as hygienic conditions. While epidemiologic studies were able to narrow down these factors, basic research discovered novel mechanisms that control the organism´s tolerance against allergens. Particularly interesting is the role of microorganisms that colonize or infect a host and thereby cause damage and immunological activation followed by sensitization or exacerbation of already existing sensitizations. However at the same time microbial activation of the immune system can help to generate a protective immunity that prevents allergen sensitization. The current book is collecting these evidences and connects epidemiologic and clinical mechanistic knowledge. Only the synthesis of this knowledge will help to find solutions to the ongoing allergy epidemic in terms of public health activities, prevention and therapy.

This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host healthy and preventing infectious diseases. The first chapters deal with several examples of the role of AMP in different epithelial organs (skin and wound healing, eye, lung, genito-urinary tract, gut), which are exposed to different kinds of infectious microorganisms and as a result produce different patterns of AMP. Examples of the dysregulation of AMP expression and function promoting infections are discussed. The capacity of AMP to restrict the availability of essential metals to bacteria as an efficient antibacterial strategy in nutritional immunity is discussed in the next chapter. Our current understanding of how vitamin D, the sunshine vitamin, influences AMP-expression and how this can affect our health is also addressed. Last but not least, the role of AMP in HIV infection and the immunomodulatory properties of AMP highlight the diverse facets of AMP in host immunity. AMP’s specific functions, including in fighting multi-resistant bacteria, suggest that they may offer therapeutic benefits – a question that is discussed in the final chapter.

Allergy is developing into one of the most prevalent diseases affecting individuals in the very early days of life. While the cause of this epidemic is still unclear, it appears that the westernized life style is playing an important role, which includes nutrition, possibly air pollution as well as hygienic conditions. While epidemiologic studies were able to narrow down these factors, basic research discovered novel mechanisms that control the organism´s tolerance against allergens. Particularly interesting is the role of microorganisms that colonize or infect a host and thereby cause damage and immunological activation followed by sensitization or exacerbation of already existing sensitizations. However at the same time microbial activation of the immune system can help to generate a protective immunity that prevents allergen sensitization. The current book is collecting these evidences and connects epidemiologic and clinical mechanistic knowledge. Only the synthesis of this knowledge will help to find solutions to the ongoing allergy epidemic in terms of public health activities, prevention and therapy.

The outbreak of SARS (Severe acute respiratory syndrome), an atypical pneumonia, has received much attention and coverage by the media and has consequently had a high impact on the public. The infectivity and route of transmission of the disease appear unusual, and it turned out to be a highly relevant threat for medical staff. This monograph provides comprehensive information on the newest insights into the SARS epidemic and the responsible infectious agent. Background information on Coronaviridae (coronavirus/torovirus) and coronavirus/torovirus-associated infections in humans and animals is also given. The volume will be a valuable source of information for researchers and clinicians in virology, epidemiology and biomedicine.

The vaccines most urgently needed are those against poverty-related diseases such as tuberculosis, malaria and HIV. However, there is a considerable gap between the development of a vaccine and the implementation as a useful measure for disease control. Major obstacles need to be overcome even after successful completion of the preclinical stage. This book provides an important link between vaccine development and application under the particular conditions in developing countries. The editors, S. H. E. Kaufmann and P. H. Lambert - one from the field of basic research and the other an expert on the side of applied vaccinology - have gathered contributions from specialists of both fields in an attempt to create a source of information that has thus far not been available.

The study of poxviruses has a long and distinguished history that includes Jenner’s founding work on smallpox vaccination. In the more than 200 years since that time we have seen the remarkable eradication of smallpox. It is difficult to overstate the significance of that achievement. It not only removed a disease that must rate as one of humankind’s greatest scourges, but also demonstrated the effectiveness of the general principle of vacci- tion in our battles against disease. This book begins with a review of smallpox and its causative agent, Variola virus. The vaccine used in the successful smallpox eradication c- paign, vaccinia virus, is reviewed in the following chapter that describes its origin and its use as a vaccine, as well as the current understanding of the molecular biology and pathogenesis of this virus. Vaccinia virus is the most intensively studied poxvirus and the descriptions of the biology of this virus are relevant to all vertebrate poxviruses. The eradication ofsmallpox has drawn attention to the potential threat posed by other orthopoxviruses that infect humans, particularly Monkeypox virus. A description of this virus is given in the third chapter. Jenner’s ori- nal vaccine is believed to have been Cowpox virus and this virus is reviewed in the chapter by Essbauer and Meyer. Additional chapters are devoted to each of the recognized genera of the vertebrate poxviruses and a f- ther chapter describes the subfamily of poxviruses infecting invertebrates. Together these provide a comprehensive review of the poxvirus family.

Community-acquired pneumonia (CAP) is a disease associated with high morbidity and mortality, with at least one third of cases requiring hospitalization, exceeding the numbers admitted for myocardial infarction and stroke. Despite a broad armamentarium of antimicrobials available, it remains an important cause of death in industrialized countries. CAP is caused by a variety of pathogens with their order of importance dependent on the location and population studied. Despite the importance of CAP, reliable data and a recommended evidence-based therapy are lacking, and basic research must be improved. The goal of this volume is to present state-of-the-art knowledge on epidemiology, clinical presentation, immunology, pathology, and diagnosis including the identification of "new pathogens". Therapeutic approaches, antibiotics resistance, disease management and vaccination strategies are also covered. The volume is of interest to researchers and clinicians in virology, epidemiology and biomedicine.

The fifth volume of Birkhäuser Advances in Infectious Diseases is focused on pediatric infectious diseases. In modern medicine, the discipline pediatric infectious diseases is an important medical specialty. The successful prevention of childhood dise- es like diphtheria, tetanus and pertussis has made a major contribution to the improvement of public health. Understanding the biology of causative agents and the pathogenesis is an essential step in achieving control and elimination of disease. Today pediatric infectious diseases research is closely interconnected with other disciplines. This volume addresses vaccination, historical, epidemiological and soc- cultural issues as well as clinical and molecular biological aspects of pe- atric infectious diseases. New insights into the pathogenesis of infection are presented and an update on diagnostics, prevention and treatment of pe- atric bacterial, viral, fungal and parasitic diseases is provided. The role of emerging new pathogens is also pointed out. Finally, the future perspectives of pediatric infectious diseases are highlighted. Therefore, this book aims at an interdisciplinary audience of clinicians and non-clinicians: pediatricians, infectious disease researchers, virologists, microbiologists as well as public health scientists and politicians. We would like to sincerely thank the staff of Birkhäuser publishers, and notably Dr. Beatrice Menz, for editing this volume of the Advances in Infectious Diseases series. Most of all we would like to thank all our c- leagues who are international experts and scientists in their respective field and who generously shared their knowledge in the broad interdisciplinary area of pediatric infectious diseases with us.

Acute and chronic hepatitis and hepatitis-related diseases such as liver failure, liver cirrhosis and hepatocellular carcinoma are among the most important causes for disabilities and death. Hepatocellular injury is due to a variety of agents including viruses, toxins, radiation, injury and drugs but also bacteria, parasites and autoimmune reactions. This volume reviews today’s knowledge about hepatitis with emphasis on comparative aspects between hepatitis in humans and animals, but also between different etiological agents. This particular viewpoint makes the book relevant for scientists from both human and veterinary medicine, gastroenterologists, pathologists, virologists and students of human and veterinary medicine.