Confluence of Research in Biotechnology for Human Welfare – serie

The eco-friendly remediation technologies for the degraded environment are indeed the “need of the hour”. Even though the regulatory mechanisms are in place to control the discharge of untreated contaminants into the natural environment, still, we could see a different picture; hence, remediation and restoration of the environment becomes an ardent requisite. The present-day fast pace of industrialization without proper disposal planning is impacting the water bodies adversely, generating the need for green management technologies. It is worth mentioning that these environment-friendly technologies are most cost-effective as well. The advancements in biotechnology have paved the way to mitigate the problem.The primary audience of this book are the students and researchers who are working in the field of toxicology and bioremediation of aquatic environments. We have primarily focused in this book on bioremediation of aquatic system toxicity, considering this as an environment-friendly system and having the least adverse effects. Hence this book aims to bring forward together on a single platform the latest research in aquatic resource management, which includes the discussions and discourses on the degradation and the effect and the remediation.This book includes a discussion on the different sources of contamination from industries or by the usage of commercial pesticides or even fertilizers. These contaminants, if discharged in their toxic form as effluent, cause harm to the aquatic systems and the subsoil and create the possibility of groundwater contamination. This book includes a discussion on the different routes of contamination and the food-chain transport possibilities of pesticide pollutants, which are very contemporary and required topics of research. It also includes relevant discussions on how to get rid of the toxicity.

Microbial biofilm plays an important role in the life cycle of microorganisms surviving in diverse and harsh environments such as extremes of temperatures, pH, salinity, nutrient scarcity etc. Biofilm formation is a survival strategy adopted by microorganisms allowing colonization in new niches by dispersal of microbes from the microbial clusters embedded within an outer polymer layer produced by the microorganism itself. This layer comprises of extracellular polymeric substances (EPS) that helps the indwelling microbes to grow and divide in a protected environment against invaders like antimicrobial agents, surfactant, biocides and phagocytic cells of host organisms. Thus, EPS matrix prevents the penetration of antimicrobials thereby allowing the indwelling microbes to survive and give rise to antimicrobial resistance posing threat to human health.The present book highlights a detailed analysis of the mechanism of biofilm formation in both Gram positive and Gram-negative bacteria and the role of quorum sensing signaling mechanism in the genetic regulation pathway. The book titled "Natural Products: Alternative therapeutics as Quorum Sensing (QS) inhibitors" provides a detailed and systematic review of mechanism of quorum sensing in both Gram positive and Gram-negative bacteria and alternative pharmacological developments as a potent solution to the rise of antimicrobial resistance during biofilm formation.Features:A systematic overview of the mechanism of quorum sensing in the development of microbial biofilmsBiofilm formation and its role in the emergence of antimicrobial resistanceRecent pharmacological development of antibiofilm remedies involving biogenic compoundsThis book serves as a reference book for researchers investigating the progression of events during microbial biofilm formation starting from the genetic cascade regulating quorum sensing to secretion of autoinducers and design of safer methodologies for the successful eradication of microbial biofilm. It may also be used as a textbook for a undergraduate level course in microbiology or microbial biotechnology.