Lung Biology in Health and Disease – serie

"Analyzes the role of peptides in promoting or suppressing inflammation. Thoroughly examines the therapeutic potential of key peptides, analogs, agonists, and antagonists that influence cell injury and repair."

This research-level reference provides a review of the morphological techniques that have become a primary method of anatomical study correlating structure and function in lung physiology and pathology. Detailing the evolution of anatomy as a research discipline, it explores general structural techn

This timely Second Edition of a landmark reference furnishes in-depth examinations of the latest developments in the physiology, pathophysiology, and clinical relevance of the respiratory muscles and chest wall-reflecting the explosion of information that has occurred since the publication of the previous edition.

This book covers several aspects of inhalation toxicology ranging from inhalation drug abuse to battlefield chemical inhalation lung injury, and emphasizes pathophysiology and therapy.

This book discriminates and emphasizes approaches that are likely to be productive in terms of understanding the causation and mechanisms of occupational lung diseases. It benefits research academicians in the field of lung diseases, and government and public health authorities.

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years.In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies.The final integrated strategies section draws the major points from the applications for disease targets and drug products.

This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery systems.

"Analyzes the role of peptides in promoting or suppressing inflammation. Thoroughly examines the therapeutic potential of key peptides, analogs, agonists, and antagonists that influence cell injury and repair."

This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies. Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthmadescribes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis and more! Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.

An up-to-the-minute reference guide for health professionals confronting pulmonary disorders in children, Pediatric Asthma offers the latest findings on this classification-defying disease and related conditions. Written by more than 20 international experts in the field, the book focuses on drug administration-issues of compliance, aerosol delivery, and pharmacokinetic differences among children-with a view toward developing new and more efficacious therapies. Provides cutting-edge analysis for more effective diagnosis of children with asthma and improved monitoring and treatment for chronic patients! With a firm theoretical grounding and reflecting the state of the art in pharmacological research and development, Pediatric Asthmareviews the prevalence, causes, and demographics of childhood asthma worldwide explores determinants of the disorder in various populations-gender, age and severity of onset, atopic status, family history, and smoking elucidates physiological factors such as airway remodeling, airway hyperresponsiveness, and persistent inflammation describes in vivo and in vitro testing for asthma-associated allergy and the pros and cons of allergen immunotherapy delineates the dynamics of the lung in terms of phenomena such as peak expiratory flow (PEF), forced vital capacity (FVC), and bronchial hyperresponsiveness (BHR) highlights the importance of patient education and self-management investigates the role that developmental psychopathologies and neurobehavioral dysfunctions may play in pediatric asthma discusses inflammatory mediators such as cytokines, chemokines, leukotrienes, and prostaglandins evaluates intravenous and inhaled 2 agonists for the bronchodilating treatment of acute severe asthma and more! Featuring over 2100 references, more than 60 user-friendly tables, and a handy Appendix on clinical monitoring of childhood asthma and recommended drug dosages for its treatment, Pediatric Asthma is an indispensable resource for pediatricians, pediatric pulmonologists, and pediatric pharmacists; clinical allergists and immunologists; general and family practitioners; and graduate and medical school students in these disciplines.

Providing an up-to-date overview of the field, this state-of-the-art reference details how sleep and circadian rhythms are interconnected, revealing the impact of various disease states on, and the molecular and genetic basis for, disrupted sleep and circadian rhythmicity and their effects on physical and mental health, safety, performance, and productivity. Integrates current and rapidly advancing discoveries of sleep and circadian rhythms! Offering an integrative approach to research findings from basic science to clinical points of view, Regulation of Sleep and Circadian Rhythms discussesthe three developmental stages of sleep in mammals the evolution of circadian timing brainstem regulation of sleep non-REM sleep and thalamocortical function cognitive correlates of behavioral states dysfunctional sleep sleep homeostasis neuroanatomy of circadian control acute effects of light organization of vertebrate circadian timing systems production, sites, and mechanisms of melatonin genetic aspects of pathological human sleep sleep alterations associated with age, disease, and psychiatric state and more! Complete with over 3200 references, tables, and figures, Regulation of Sleep and Circadian Rhythms is an essential resource for clinical neurologists and neurobiologists, pulmonologists, psychiatrists and behavioral scientists, endocrinologists and neuroendocrinologists, chronobiologists, sleep specialists, general medicine practitioners and internists, gerontologists, psychologists, and graduate and medical school students in these disciplines.

This book sums up the mechanistic basis, current status, and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy, identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development.Makes connections among the underlying pharmacology, impact of new simulation models, newly recognized molecular targets, and therapeutic outcomes of short- and long-term steroid inhalation therapy!Containing more than 1600 works cited, drawings, tables, equations, and micrographs, Inhaled Steroids in Asthmadescribes the developmental history of inhaled steroids and provides general models for lung selectivity considers the best way to select inhaled steroids clarifies local metabolism, airway and lung uptake and retention, and other determinants of once-daily usage addresses variations in lung deposition and total bioavailability among available steroids and formulations surveys the dynamics of receptor gene-mediated processes analyzes the role of chemokines in airway allergic inflammatory diseases discusses the effects of inhaled steroids in vivo on cell progenitors in asthma and rhinitis details measuring airway inflammation as a guide for treatment decisions outlines the clinical relevancy of exhaled nitric oxide in asthma covers optimal trial design for judging antiasthmatic potency and efficacy evaluates the safety of inhaled steroids Written by more than 40 of the world's leading authorities and investigators, Inhaled Steroids in Asthma is an authoritative reference for pulmonologists and pulmonary disease specialists; physiologists; allergists; immunologists; molecular, cell, and lung biologists; pediatricians; pharmaceutical scientists and pharmacologists; and medical school and upper-level undergraduate, graduate, and medical school students in these disciplines.

Exploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders.Compiles previously unpublished data from the first extensive scientific investigations of Xolair!IgE and Anti-IgE Therapy in Asthma and Allergic Diseasereviews studies on the distribution of serum IgE levels of normal and asthmatic populations in developed regions of the world such as the United States, Canada, Scandinavia, New Zealand, and Europe offers novel methods for the design and formulation of monoclonal antibodies discusses the use of allergen bronchoprovocation to identify the characteristics and efficacy of new antiasthma and antiallergy medications examines the role of IgE in food and parasitic allergiesand covers the pathogenesis of atopic dermatitis and urticaria novel strategies to target mast cells and basophils murine models of allergic pulmonary inflammation the pathophysiology of allergic rhinitisSupplemented with nearly 2000 contemporary references to facilitate further study, IgE and Anti-IgE Therapy in Asthma and Allergic Disease is an in-depth and timely source for basic and clinical immunologists; allergists; pulmonologists and pulmonary disease specialists; physiologists; molecular, cellular, and lung biologists; pediatricians; internists; and graduate and medical school students in these disciplines.

Focusing specifically on the inter-relationship between the nose and the lungs, this reference examines the structural connections between the upper and lower airways and explores the microscopic and gross anatomy of the respiratory tract. Considering functional relationships, as well as human and animal models of disease, this source delivers articles on the pathophysiology, epidemiology, diagnosis and treatment of allergic airway dysfunction and other illnesses affecting the entire respiratory tract.

Discusses new treatment strategies for malignant mesothelioma, pulmonary edema, fibrosis, asthma, emphysema, and bronchiectasis.Proteoglycans in Lung Disease considersglycosaminoglycans as novel therapeutic agents or targets in lung disease the role of proteoglycans in determining mechanical behavior of lung tissue hyaluronan and its receptors in wound healing, inflammation, vasculogenesis, and angiogenesis the impact of small proteoglycans on matrix assembly versican as a modulator of cell adhesion, migration, and proliferation antiproliferative activity of heparin and its derivatives on pulmonary artery smooth muscle cells the effects of mechanical strain on proteoglycans the functions of proteoglycans in the vascular wall the effect of hypoxia on glycosaminoglycans in the lung Comprised of more than 1940 references, Proteoglycans in Lung Disease

Considering the epidemiology of COPD, this title collects all available knowledge on the subject, featuring data on the national emphysema treatment trial. It explores the epidemiology of emphysema, the management of complications and surgical controversies in lung volume reduction surgery for emphysema (LVRS).

This book discriminates and emphasizes approaches that are likely to be productive in terms of understanding the causation and mechanisms of occupational lung diseases. It benefits research academicians in the field of lung diseases, and government and public health authorities.

Exploring the wide array of structures, substances, and environments that are primary factors in the initiation or inhibition of sleep, this reference highlights key findings from respected professionals around the globe on the social and economic burden of impaired performance, productivity, and safety arising from sleep deprivation-studying pharmacological treatment regimens for sleep disturbance, as well as cognitive and behavioral coping strategies.

A discussion of the epidemiology, clinical features, and differential diagnoses of idiopathic pulmonary fibrosis (IPF). Key topics include the role of polymorphonuclear leukocytes in the pathogenesis of pulmonary fibrosis, and current treatment options, including medical therapy and lung transplantation.

Collecting research from leading specialists in the field, this reference contains the latest studies on the genetic and environmental origins, pathogenesis, and immunology of asthma-promoting new research pathways for the development of new therapeutic interventions in the prevention of this common disease.

This reference compiles the most current technical and biological data available to survey the state-of-science in the care and management of patients with bronchopulmonary dysplasia, COPD, and other forms of lung disease-tracking the initiation and progression of processes that cause airway obstruction, the biologic and physiological abnormalities that characterize COPD, and the potential reversibility of the inflammatory response in COPD for improved patient diagnosis and treatment.

Continuing to serve as the definitive source on the subject, Pneumocystis Pneumonia offers a detailed update on the biology, pathogenesis, genetics, and immunology of Pneumocystis. This reference offers invaluable research and previously unpublished findings, and provides in-depth reviews on the development of new drugs, insights into host-pathogen interactions, emerging diagnostic techniques, global perspectives of the infection, future directions in the field, and more. This volume also provides a discussion of the genetic diversity of the disease in the context of nomenclature and recognition of species and molecular typing as well as description of the ongoing genome project.

Progressing from general scientific principles and concepts to in-depth topical discussions of current research and treatment methods, this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and repair. Extensive coverage is provided on key mediators and pathways important in acute and chronic pulmonary inflammation and lung injury, as well as the mechanistic pathophysiology of related diseases ranging from clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and other subacute and chronic conditions. Additional chapters also address vascular dysfunction, surfactant dysfunction, reactive oxygen/nitrogen species, and cell and animal models of acute and chronic lung injury.

Exploring the functional anatomy and physiology of the ventilatory control system from the intracellular to the integrative level, this references serves as the first source to offer comprehensive coverage of the influences of various pharmacological agents on the control of breathing.

This reference serves as the most current and comprehensive source on the many aspects of sarcoidosis ranging from the basic science and pathophysiology of the disease to patient evaluation and treatment-providing a detailed analysis of the pulmonary aspects of the condition including chapters on radiographic manifestations, bronchoalveolar lavage research, pulmonary function studies, and proposed markers for the diagnosis and management of the disease.

A comprehensive review of the scientific and clinical aspects of acute and chronic cough, this reference focuses on recent developments in our understanding of the molecular biology of putative cough receptors, the neural mechanisms involved in the afferent and efferent limbs, the central processing of the cough reflex, and peptides and other substances that may mediate or modulate the cough reflex. With chapters written by acknowledged authorities in the field, this handbook covers current and potential therapeutic agents, various methodologies to measure cough reflex sensitivity, and clinical approaches for the assessment of chronic cough in adults and children.

This volume presents a global overview of the role of ion flux via transmembrane ion channel proteins in the regulation of pulmonary vascular tone and in the vascular remodeling processes associated with pulmonary vascular disease-offering a comprehensive review of the multiple families of ion channels that have been identified and characterized in pulmonary artery smooth muscle, as well as a practical discussion of experimental tools for the study of ion channel physiology and molecular biology.

This book provides a current and integrated approach to the subject of genetic determinants of pulmonary disease with emphasis on physiologic derangements and genetic mechanisms. It describes the epidemiologic-genetic approach to chronic pulmonary disease.

Performing a thorough and detailed study of one of the most common yet less accurately understood causes of human illness, this all-inclusive reference examines the epidemiology, pathophysiology, and future treatment options for asthma and respiratory infections.Contains up-to-date results from clinical trials of antiviral agents that explore new avenues of therapy-including interferons, ICAM-1 receptor blockades, vaccines, and mediator antagonists!