Novartis Foundation Symposia – serie
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55 produkter
Molecular Mechanisms Influencing Aggressive Behaviours
Av Gregory R. Bock, Jamie A. Goode
Inbunden, 2005
2211 kr
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This book features scientists from a broad spectrum of disciplines discussing recent data on aggression in laboratory animals with particular reference to possible implications for understanding human aggression. Chapters focus on the major current experimental issues in the study of aggression in …
Percept, Decision, Action
Bridging the Gaps
Av Derek J. Chadwick, Matthew Diamond m. fl.
Inbunden, 2006
2327 kr
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Seemingly simple behaviours turn out, on reflection, to be discouragingly complex. For many years, cognitive operations such as sensation, perception, comparing percepts to stored models (short-term and long-term memory), decision-making and planning of actions were treated by most neuroscientists …
Heart Failure
Molecules, Mechanisms and Therapeutic Targets
Av Gregory R. Bock, Jamie A. Goode
Inbunden, 2006
2400 kr
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Heart failure is the main cause of death and disability in the industrialized world. There is a major need for novel therapeutics for prevention and reversal of cardiac pathology associated with heart failure and cardiac enlargement. Over recent years, dramatic progress has been made in unravelling …
Epithelial Anion Transport in Health and Disease
The Role of the SLC26 Transporters Family
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2006
2327 kr
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Cl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of the SLC26 transporters family. It is now clear …
Genetics of Autoimmunity
Av Gregory R. Bock, Jamie A. Goode
Inbunden, 2005
2348 kr
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This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated. Incorporating data on disease-associated chromosomal loci that has been …
Innate Immunity to Pulmonary Infection
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2007
2327 kr
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Part of the prestigious Novartis Foundation series, this volume uniquely addresses the use of innate immunity to treat or prevent infectious diseases of the lung. Innate Immunity to Pulmonary Infection: Provides a comprehensive overview of pulmonary infectious diseases, including basic pathology, …
Sepsis
New Insights, New Therapies
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2007
2371 kr
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Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics …
Fatty Acid and Lipotoxicity in Obesity and Diabetes
Av Gregory R. Bock, Jamie A. Goode
Inbunden, 2008
2444 kr
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The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid …
Novel and Re-emerging Respiratory Viral Diseases
Av Gregory R. Bock, Jamie A. Goode
Inbunden, 2008
2400 kr
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The past decade has seen mounting global concern regarding viral outbreaks such as SARS, avian influenza and West Nile virus. In 2004 and 2005, reports of bird-to-human, and possible human-to-human, transmissions of the H5N1 influenza viruses raised fears that these viruses could cause a pandemic …
Mitochondrial Biology
New Perspectives
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2007
2327 kr
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With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews …
Inflammatory Bowel Disease
Crossroads of Microbes, Epithelium and Immune Systems
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2004
2348 kr
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Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of …
Stem Cells
Nuclear Reprogramming and Therapeutic Applications
Av Novartis, Gregory R. Bock m. fl.
Inbunden, 2005
2267 kr
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Understanding stem cells at the molecular level is essential to understanding their behaviour in a physiological context. This volume in our acclaimed Novartis Foundation series features animated discussion from the world’s experts in this topic on the important ethical issues that are raised by …
Biology of Extracellular Molecular Chaperones
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2008
2327 kr
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The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the …
Genetics and Biology of Sex Determination
Av Novartis, Derek J. Chadwick m. fl.
Inbunden, 2002
2267 kr
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Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its …
Autism
Neural Basis and Treatment Possibilities
Av Novartis, Gregory R. Bock m. fl.
Inbunden, 2003
2379 kr
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This book draws together contributions from some of the leading investigators in the field of autism to consider specific problem areas in current research. Each contributor brings expertise from a different field, providing a balanced view of the whole spectrum of study of this disorder. It covers …
Immunoinformatics
Bioinformatic Strategies for Better Understanding of Immune Function
Av Novartis, Gregory R. Bock m. fl.
Inbunden, 2003
2335 kr
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The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. …
Mammalian TRP Channels as Molecular Targets
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2004
2259 kr
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This book brings together contributions from key investigators in the area of Transient Receptor Potential (TRP) channel structure and function. It covers the structure, function and regulation of mammalian TRP channels and mechanisms of signal transduction. The discussions indicate research that …
Osteoarthritic Joint Pain
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2004
2327 kr
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Osteoarthritis is a chronic degenerative disease associated with joint pain and loss of joint function. It has an estimated incidence of 4 out of every 100 people and significantly reduces the quality of life in affected individuals. The major symptoms are chronic pain, swelling and stiffness; …
Pathological Pain
From Molecular to Clinical Aspects
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2004
2327 kr
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This book brings together contributions from key investigators in the area of pathological pain. It covers the molecular basis of receptors and channels involved in nociception, the possible messages that cause neuropathic plasticity, spinal plasticity in neuropathy, plastic changes in opioid …
Neuronal and Cognitive Effects of Oestrogens
Av Novartis, Derek J. Chadwick m. fl.
Inbunden, 2000
2335 kr
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Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role. It has been shown that oestrogen acts as a neural growth factor with important influences on the …
Neural Transplantation in Neurodegenerative Disease
Current Status and New Directions
Av Novartis, Derek J. Chadwick m. fl.
Inbunden, 2000
2335 kr
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The field of neural transplantation is at a crucial stage in its development, with results of important clinical trials on transplantation in patients with Parkinson's disease expected soon and novel, alternative approaches to fetal transplantation being actively investigated. This timely book …
Molecular Basis of Skeletogenesis
Av Novartis Foundation Symposium, Gail Cardew m. fl.
Inbunden, 2001
2335 kr
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Brings together a cross-fertilization of ideas between human molecular genetics, develeopmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis.
Chronic Obstructive Pulmonary Disease
Pathogenesis to Treatment
Av William MacNee, Novartis Foundation Symposium m. fl.
Inbunden, 2001
2261 kr
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Chronic obstructive pulmonary disease (COPD) is the most common respiratory disorder of adults in the developed world and is the fourth main cause of death in the USA. It is also associated with high morbidity, and poses an enormous burden of suffering and expense. Despite this, the disease has …
Cell Cycle and Development
Av Novartis, Gregory R. Bock m. fl.
Inbunden, 2001
2181 kr
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This book brings together scientists working at the interface between the cell cycle, cell growth and development in a variety of model systems and research paradigms. The focus is on understanding how such diverse developmental inputs can modulate cell cycle regulation and, reciprocally, how a …
Gastroenteritis Viruses
Av Novartis Foundation Symposium, Mary Estes m. fl.
Inbunden, 2001
1468 kr
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This important book covers the structure and molecular biology of small round structured viruses (SSRVs) such as caliciviruses and astroviruses, and the basic pathology of infection. It provides readers with the knowledge needed to make progress in the prevention and treatment of these infections. …
From Genome to Therapy
Integrating New Technologies with Drug Development
Av Novartis, Gregory R. Bock m. fl.
Inbunden, 2000
2267 kr
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This important and exciting work brings together a high-calibre group of experts to discuss the practical application of genomic information to the development of drugs. Recent technological advances have led to a rapid acceleration in our ability to gather genetic data. The complete genetic …
Insect-Plant Interactions and Induced Plant Defence
Av Novartis, Derek J. Chadwick m. fl.
Inbunden, 1999
2310 kr
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Insect-Plant Interactions and Induced Plant DefenceChair: John A. Pickett, 1999 This book examines the sophisticated mechanisms that plants use to defend themselves against attack by insects and pathogens, focusing on the networks of plant signalling pathways that underlie these defences. In …
Signalling Networks in Cell Shape and Motility
Av Gregory R. Bock, Jamie A. Goode
Inbunden, 2005
1988 kr
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This book features contributions from experts in cell biology, genetics, neurobiology, immunology and structural biology. The unifying element is that they all study processes of cell shape change and motility. Several key questions in this field of research are discussed: What are the organising …
Mast Cells and Basophils
Development, Activation and Roles in Allergic / Autoimmune Disease
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2005
2047 kr
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The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic …
Signalling Pathways in Acute Oxygen Sensing
Av Derek J. Chadwick, Jamie A. Goode
Inbunden, 2006
1988 kr
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Oxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all subjects of controversy. This book evaluates the various mediators that have been proposed, …
