Springer Study Edition – serie

This book really ought to be read on vacation, just for enjoyment. Granted, cancer is, literally, a deadly serious matter, and cancer research is primarily a part of medicine with Hippocrates in its back­ ground. Yet, cancer research is also natural science, and as such it yields the joys and sorrows of any science. The cancer problem is also a brain teaser, a challenge for the curious. This introductory report on experimental cancer research is there­ fore directed to curious students of many disciplines: naturally to medical students, but also to chemists and physicists who have an interest in biological phenomena; biology students will surely en­ counter pr9blems peculiar to their field in what is supposedly a medi­ cal one. We have attempted to write without assumptions to a certain degree, for a chemist is essentially in over his head in medicine, and a physician has only the slightest idea of the chemical problems im­ portant in cancer research. We had no intention of giving a complete view of the field, and from the large number of different lines of development we have chosen only a few. Chemotherapy, as an ex­ ample, has been treated quite cursorily, along with RNA tumor viruses, although it is possible that just these subjects are especially important for human tumors. Tumor induction via radiation could only be mentioned in passing, in spite of its great practical significance; similarly the role of hormones was only intimated.

This little book was assembled from the authors' lectures to medical students and was originally published as one volume in the series Human Physiology, edited by O. H. Gauer, K. Kramer, and R. Jung. The editors intended that each volume in this series be independent of the others and we have kept to this purpose. We have included here only material that we feel is necessary for medical students to know in order to understand kidney function in health and, by later extrapolation, in disease. The contents rest on accepted principles estab­ lished by experiments, and little space is given to what is controversial, hypo­ thetical, or unresolved. We are pleased that Dr. Coxon has been motivated to prepare an English language version of this text. We hope that it will serve as a ready reference and review source for the beleaguered medical student. P. Deetjen J. W. Boylan K.

This textbook has its ongm in a longstanding international profes­ sional and personal relationship of the authors. The success of the German edition was a result of the interest of the German authors, Dr. K. Knorr and Dr. C. Lauritzen, in synthesizing basic and clinical information in a textbook, the size and scope of which are appropriate to the modern undergraduate medical student. A unique feature of the volume was the addition of American gynecological thinking by Dr. F. K. Beller, who spent 12 years at New York University before returning to Germany. The English edition, which is aimed at the American medical student, has enlisted the services of Dr. R. M. Wynn, whose academic career has been in the United States, although he is thoroughly familiar with principles and practices of German gynecology. The English edition is not merely a translation of the German text. Rather, it incorporates most of the material, but with judiciOUS deletions, additions, and substitutions it brings the teaching into the mainstream of American medical education. We acknowledge with gratitude the expert editional assistance of Dr. Henriette Knorr-Gartner. Dr. R. Schuh­ mann and Mr. H. Brandt of Springer-Verlag were responsible for the histological sketches. The late Dr. H. Roemer prepared the section on psychosomatic disorders; Dr. F. W. Ahnefeld assisted in the section on shock; and Dr. H. Breinl helped to prepare the chapter on anatomy in the German edition.

The present English edition is not a mere translation of the German original. Many new problems have been added and there are also other changes, mostly minor. Yet all the alterations amount to less than ten percent of the text. We intended to keep intact the general plan and the original flavor of the work. Thus we have not introduced any essentially new subject matter, although the mathematical fashion has greatly changed since 1924. We have restricted ourselves to supplementing the topics originally chosen. Some of our problems first published in this work have given rise to extensive research. To include all such developments would have changed the character of the work, and even an incomplete account, which would be unsatisfactory in itself, would have cost too much labor and taken up too much space. We have to thank many readers who, since the publication of this work almost fifty years ago, communicated to us various remarks on it, some of which have been incorporated into this edition. We have not listed their names; we have forgotten the origin of some contributions, and an incomplete list would have been even less desirable than no list. The first volume has been translated by Mrs. Dorothee Aeppli, the second volume by Professor Claude Billigheimer. We wish to express our warmest thanks to both for the unselfish devotion and scrupulous conscientiousness with which they attacked their far from easy task.

In tracing their origin and their fate, the beginning and the end of their environment, humans have often been guided by curiosity. Such concern has helped man to discover, among other things, the structure of the universe from star to atom and the evolution of life from unicellular organism to human being. The study of disease is unique. Although it may have been in­ spired by the curiosity of a few, it has always been the concern of all, because preventing or curing disease has meant survival not only of individuals, but of entire nations, not only of humans, but of fellow living creatures. If greed, force, religion, and language have been major causes of wars, diseases, more than arms, have often decided the outcome of battles and thereby have woven the pattern of history. For millennia, a large fraction of the human race believed that disease expressed the wrath of God(s) against individuals or societies. Therefore, only priests or priestesses, kings, and queens were endowed with the power of healing. In the West, Hippocrates is credited for exorcising this concept of disease and for objectively describing and cataloguing them. The contributions of Greek physicians to Western medicine made possible more accurate diagnoses and prognoses.

Growth of population, communication and interdependence among countries has sharpened the impact of natural disasters. Not only have calamities and miseries been given wider publicity, but the realization has grown that through rational study and foresight much can be done to mitigate these hazards to life and social wellbeing. In this book we present a summary account of hazards which nowadays are usually classified as geological: earthquakes, faulting, tsunamis, seiches, vol­ canoes, avalanches, rock and soil slides, differential settlement and liquefaction of soil, and inundation. The book is aimed first at the general reader who is interested in studying the history of such hazards and examining ways that risk can be reduced even if all dangers cannot be eliminated. We also hope that the book will be useful to college students in introductory courses in geology, engineering, geography, country and urban planning, and in environmental studies. We have tried to bring dut for the students the problems that remain to be solved.

Since 1950 geologists have learned more about the origin and lithification of carbonate sediments than in all the previous years of the history of science. This is true in all the diverse fields of carbonate geology: the study of Recent environments, marine zoology and botany, organic geochemistry, trace element and isotope geochemistry, mineralogy, microfacies of depositional environments, and trace-fossil and sedimentary structure investigation. A synthesis of this new knowledge is just beginning to be formulated. The purpose of this volume is to introduce the advanced student and petroleum explorationist principally to one important aspect of this study: to some of the principles of carbonate geology which may serve to interpret the depositional environments of ancient strata and to better define their sequences and patterns. Chapter I is a brief review of principles of carbonate sedimentation. (For a full discussion of the mineralogy, geochemistry, and diagenesis of carbonates along with a review of Holocene sediments, one may refer to Bathurst's (1971) and Milliman's (1974) texts.) Chapter II reviews stratigraphic and paleotectonic concepts and discusses a general model for carbonate deposition. Chapter III offers an outline of carbonate petrography, concentrating on lithologic descrip­ tion for the purposes of environmental interpretation. For a further review of this subject and excellent photomicrographs, Horowitz and Potter (1971) and Majewske (1969) may be used.

The Second Law of Thermodynamics has been called the most important law of nature: It is the law that gives a direction to processes that is not inherent in the laws of motion, that says the state of the universe is driven to thermal equilibrium. Its mathematical formulation is simple: The entropy of a closed system cannot decrease. Since the recognition that macroscopic phenomena have an atomic basis, it has remained a fundamental problem to reconcile the increase of entropy with the known reversibility of all the laws of microscopic physics. Professor Michael Mackey of McGill University here explores the dynamical basis for the Second Law, that is, he seeks to illuminate the fundamental dynamical properties required for the construction of a successful statistical mechanics. Aimed at physicists and applied mathematicians with an interest in the foundations of statistical mechanics, the book includes such new material as: a demonstration that the black body radiation law can be deduced from maximal entropy principles; a discussion of sufficient conditions for the existence of at least one state of thermodynamic equilibrium; a description of the behavior of entropy in asymptotically periodic systems; a necessary and sufficient condition for the evolution of entropy to a global maximum; and a presen- tation of the three main types of ergodic theorems and their proofs. He also explores the potential role of incomplete knowledge of dynamical variables, measurement imprecision, and the effects of noise in giving rise to entropy increases.

The exploration of the upper atmosphere was given a jump start in the United States by German V-2 rockets - Hitler's "vengeance weapon" - captured at the end of World War II. The science performed with these missiles was largely determined by the missile itself, such as learning more about the medium through which a ballistic missile travels. Groups rapidly formed within the military and military-funded university laboratories to build instruments to investigate the Earth's upper atmosphere and ionosphere, the nature of cosmic radiation, and the ultraviolet spectrum of the Sun. Few, if any, members of these research groups had prior experience or demonstrated interests in atmospheric, cosmic-ray, or solar physics. Although scientific agendas were at first centered on what could be done with missiles and how to make ballistic missile systems work, reports on techniques and results were widely publicized as the research groups and their patrons sought scientific legitimacy and learned how to make their science an integral part of the national security state. The process by which these groups gained scientific and institutional authority was far from straightforward and offers useful insight both for the historian and for the scientist concerned with how specialties born within the military services became part of post-war American science.

This is a lucid account of the highlights in the historical development of the calculus from ancient to modern times - from the beginnings of geometry in antiquity to the nonstandard analysis of the twentieth century. It emphasizes the genesis and evolution of both fundamental concepts and computational techniques. The intended audience includes not only students of the history of mathematics, but also the wider mathematical community, specifically those who study, teach and use calculus. Among the distinctive features of this exposition are historically motivated exercises and carefully chosen illustrative examples. Numerous sections of the book are suitable for use in courses in introductory and advanced calculus as well as the general history of mathematics.

The earliest investigations that can be called scientific are concerned with the sky: they are the beginnings of astronomy. Many early civilizations produced astronomical texts, and several cultures that left no written records left monuments and artifacts-ranging from rock paintings to Stonehenge-that show a clear interest in astronomy. Civilizations in China, Mesopotamia, India and Greece had highly developed astronomies, and the astronomy of the Mayas was by no means negligible. Greek astronomy, as developed by the medieval Arab philosophers, evolved into the astronomy of Copernicus. This displaced the earth from the central stationary position that almost all earlier astronomies had assumed. Soon thereafter, in the first decades of the seventeenth century, Kepler found the true shape of the planetary orbits and Galileo introduced the telescope for astronomical observations.

Again rapid advances in the brain sciences have made it necessary, after only a few years, to issue a revised edition of this text. All the chapters have been reviewed and brought up to date, and some have been largely rewritten. The major revision has occurred in the chap­ ters on the autonomic nervous system and the integrative functions of the central nervous system. But in the discussion of the motor systems and other subjects as well, recent insights have necessitated certain conceptual modifications. In the description of the autonomic nervous system, the role of the intestinal innervation has been brought out more clearly than before. In addition, there is a new presentation of the physiology of smooth muscle fibers, and more attention has been paid to the postsynaptic adrenergic receptors, because of the increasing therapeutic signifi­ cance of the at f3 receptor concept. A substantial section on the genital reflexes in man and woman, including the extragenital changes during copulation, has also been added. The text on the integrative functions of the central nervous system has been expanded to include, for the first time, material on brain metabolism and blood flow and their dependence on the activity of the brain. Reference is also made to recent results of research on split­ brain and aphasic patients and on memory, as well as on the physiol­ ogy of sleeping and dreaming.

From the reviews: "The book has a broad and general coverage of both the mathematics and the numerical methods well suited for graduate students." Applied Mechanics Reviews #1 "This is a very well written book. The topics are developed with separate headings making the matter easily understandable. Computer programs are also included for many problems together with a separate chapter dealing with the application of computer programs to heat transfer problems. This enhances the utility of the book." Zentralblatt für Mathematik #1

The main purpose of this book is to serve as a university textbook for a first course in astronomy. However, we believe that the audience will also include many serious ama­ teurs, who often find the popular texts too trivial. The lack of a good handbook for am­ ateurs has become a problem lately, as more and more people are buying personal com­ puters and need exact, but comprehensible, mathematical formalism for their programs. The reader of this book is assumed to have only a standard high-school knowledge of mathematics and physics (as they are taught in Finland); everything more advanced is usually derived step by step from simple basic principles. The mathematical background needed includes plane trigonometry, basic differential and integral calculus, and (only in the chapter dealing with celestial mechanics) some vector calculus. Some mathematical concepts the reader may not be familiar with are briefly explained in the appendices or can be understood by studying the numerous exercises and examples. However, most of the book can be read with very little knowledge of mathematics, and even if the reader skips the mathematically more involved sections, (s)he should get a good overview of the field of astronomy. This book has evolved in the course of many years and through the work of several authors and editors. The first version consisted of lecture notes by one of the editors (Oja).

The last decade has seen a considerable renaissance in the realm of classical dynamical systems, and many things that may have appeared mathematically overly sophisticated at the time of the first appearance of this textbook have since become the everyday tools of working physicists. This new edition is intended to take this development into account. I have also tried to make the book more readable and to eradicate errors. Since the first edition already contained plenty of material for a one­ semester course, new material was added only when some of the original could be dropped or simplified. Even so, it was necessary to expand the chap­ ter with the proof of the K-A-M Theorem to make allowances for the cur­ rent trend in physics. This involved not only the use of more refined mathe­ matical tools, but also a reevaluation of the word "fundamental. " What was earlier dismissed as a grubby calculation is now seen as the consequence of a deep principle. Even Kepler's laws, which determine the radii of the planetary orbits, and which used to be passed over in silence as mystical nonsense, seem to point the way to a truth unattainable by superficial observation: The ratios of the radii of Platonic solids to the radii of inscribed Platonic solids are irrational, but satisfy algebraic equations of lower order.

This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entire field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost impossible for anyone person to stay informed on this subject by reading the primary literature. At the same time it is becoming increasingly apparent that these of universal importance in biology and medicine and that the substances are original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony­ stimulating factors," was quite artifactual; they are in fact the basis of a com­ mon language for intercellular communication. As a set they affect essentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research. This treatise is divided into four main sections. After three introductory chapters, its principal focus is the detailed description of each of the major peptide growth factors in 26 individual chapters.

In recent years, molecular biology has infiltrated into all branches of botany. This is particularly true of plant physiology. This book attempts to provide an introduction to the metabolic and developmental physiology of higher plants from a molecular biological point of view. Starting from the heterocatalytic function of DNA the first ten chapters deal with metabolism; development is presented in the last nine, starting from the autocatalytic functions of DNA and including certain topics oriented more toward metabolic physiology. Both fields of plant physiology are so closely linked that an in tegrated presen tation of this kind seemed not only possible but desirable. In contrast to other accounts, an attempt has been made to give equal weight to metabolism and development. In particular, the so-called "sec­ ondary" plant materials, which are of considerable interest to the phar­ macist, the nutrition technologist, the plant breeder, and the agriculturalist, as well as to the biologist, are treated sufficiently. It is ob­ vious that the wealth of material made an illustrative style of presentation necessary. The book is intended for beginners, and so it has had, in part, to be simplified. Even so it has not been possible to write it without mentioning hypotheses that anticipate much more research. The beginner ought also to learn how working hypotheses are first postulated on the basis of cer­ tain facts and then must either be proved or refuted.

In 1963, the first edition of Chemistry of Viruses was published as a contribution to the series on viruses sponsored by Protoplasmatologia. An aim of the first edition was to review some major principles and techniques of chemical virology in a concise manner and to accompany this review with a compilation of pertinent references. It was anticipated that this exercise would be helpful to the author in his teaching and research and, hopefully, would be useful to readers as well. The literature of virology has grown enormously since then, and it is even more urgent to have a succinct survey. In addition, few authors have attempted to integrate the findings pertaining to the various major classes of viruses (that is, animal, bacterial, and plant viruses) but, rather, have chosen to assemble large monographs dealing in depth with facts and fancies pertaining to specific groups of viruses. Such works are valuable for pursuit of particular topics but fail to yield a brief, integrated view of virology. The present edition of Chemistry of Viruses aspires to such a review. A serious attempt was made to deal concisely with every major topic of chemical virology and to present examples from different classes of viruses. Numerous references are given to original articles and review papers as well as to selected books.

A two-week summer short course entitled Current Statistical Methods in Geology supported by the National Science Foundation was held at the University of Illinois at Chicago Circle in Chicago, Illinois from June 19 to June 30, 1972. The aim of the short course was to bridge the gap between the traditional first courses in sta­ tistics offered at most educational institutions and geostatistics as it is being developed by geologists and statisticians engaged in the application of statistics in geology. The course was intended for geology college teachers who were either then teaching or preparing to teach a course within their department dealing with computer ap­ plications and the use of statistical methods in geology. This book arose out of the class notes which were prepared by the course director and the invited lecturers. We are grateful to the 28 teachers who attended for their enthu­ siastic interest and thoughtful responses to the many statistical concepts presented to them as geologists during the two weeks of the course. I am deeply grateful to my graduate assistants, Richard Kolb and Andrea Krivz, for the long hours spent in collating the course mater­ ials, testing the various computer programs, and instructing the par­ ticipants in the use of computer BASIC.

Trees have the distinction of being the largest and oldest living organisms on earth. Although the herbaceous habit has made unprecedented evolutionary gains since the middle and late Cenozoic, trees still are the most conspicuous plants covering the habitable land surface of the earth. Man has long sought their shelter and protection, utilized their food and fiber, and often exploited them to his own detriment. Trees have always been of much interest to botanists, and many of the early investigations concerning the structure and function of plants were conducted with trees. At the beginning of the present century the use of trees for basic investigations began to decline. The reasons for this are obvious. Investigations of structure and function began to shift from whole organisms to tissues, then to individual cells, and finally to cellular organelles and subcellular particles. Physiological research became increasingly more detailed and complex, requiring more and more precisely controlled laboratory conditions. Hence, a relatively small number of herbaceous plants, various unicellular algae, fungi, and bacteria have become standard research material in most laboratories.

Inhelder in her introduction. The reason for this unity is that explanatory adequacy can be attained only by exploring the formative and constructive aspects of development. To explain a psychologic reaction or a cognitive mechanism (at all levels, including that of scientific thought) is not simply to describe them, but to comprehend the processes by which they were formed; failing that, one can but note results without grasping their meaning. JEAN PlACET VI Man distinguishes himself from other creatures primarily by his abstract reasoning capacity and his ability to communicate his knowledge by highly complex symbolic processes. What is called "humanity" and progress is to a large degree a measure of his consciousness and the deployment of his creative potentials. There are few scientists who have explored the universe of cogni­ tion, and contributed to the understanding of the realm of knowledge, with greater genius, care, and scientific intuition than Jean Piaget and his longtime collaborator Barbel Inhelder. Professor Inhelder and her assistant Dr. Harold Chipman realized this book in spite of the heavy load of research, teaching, and administra­ tive duties in a rapidly expanding Institute. It is therefore a particular pleasure for me to presen t this book.

From the reviews: "...Here we have a book which we can wholeheartedly suggest. The mathematics is sound and pared to essentials; the examples are an impressive, well-chosen selection from the biomathematics literature, and the problem sets provide both useful exercises and some fine introductions to the art of modeling...Batschelet has written an introduction to biomathematics which is notable for its clarity - not only a clarity of presentation, but also a clarity of purpose, backed by a sure grasp of the field..." #Bulletin of Mathematical Biology#1 "For research workers in the biomedical field who feel a need for freshening up their knowledge in mathematics, but so far have always been frustrated by either too formal or too boring textbooks, there is now exactly what they would like to have: an easy to read introduction. This book is highly motivating for practical workers because only those mathematical techniques are offered for which there is an application in the life sciences. The reader will find it stimulating that each tool described is immediately exemplified by problems from latest publications." #Int. Zeitschrift fur klinische Pharmakologie, Therapie und Toxikologie#2

From the reviews: "...This is an extremely useful reference text for the sedimentary geologist to own. It is well produced with clear illustrations and text, and gives excellent factual information on a large number of topics."(Palaeogeography, Palaeoclimatology, Palaeoecology)"...represents a significant contribution to the literature of geoscience. It should be in the library of anyone seriously intereted in sedimentology."(Marine Geology)"This book is still unsurpassed in providing a good, basic synthesis of modern sedimentary environments, especially the physical attributes of the deposits being formed and the processes responsible..." (Sedimentary Geology)

Aquatic chemistry is becoming both a rewarding and substantial area of inquiry and is drawing many prominent scientists to its fold. Its literature has changed from a compilation of compositional tables to studies of the chemical reactions occurring within the aquatic environments. But more than this is the recognition that human society in part is determining the nature of aquatic systems. Since rivers deliver to the world ocean most of its dissolved and particulate components, the interactions of these two sets of waters determine the vitality of our coastal waters. This significant vol­ ume provides not only an introduction to the dynamics of aquatic chem­ istries but also identifies those materials that jeopardize the resources of both the marine and fluvial domains. Its very title provides its emphasis but clearly not its breadth in considering natural processes. The book will be of great value to those environmental scientists who are dedicated to keeping the resources of the hydrosphere renewable. As the size of the world population becomes larger in the near future and as the uses of materials and energy show parallel increases, the rivers and oceans must be considered as a resource to accept some of the wastes of society. The ability of these waters and the sediments below them to accommodate wastes must be assessed continually. The key questions relate to the capacities of aqueous systems to carry one or more pollutants.

In a time of multiprocessor machines, message switching networks and process control programming tasks, the foundations of programming distributed systems are among the central challenges for computing sci enti sts. The foundati ons of di stributed programming compri se all the fasci nating questions of computing science: the development of adequate com putational , conceptual and semantic model s for distributed systems, specification methods, verification techniques, transformation rules, the development of suitable representations by programming languages, evaluation and execution of programs describing distributed systems. Being the 7th in a series of ASI Summer Schools at Marktoberdorf, these lectures concentrated on distributed systems. Already during the previous Summer School s at Marktoberdorf aspects of di stributed systems were important periodical topics. The rising interest in distributed systems, their design and implementation led to a considerable amount of research in this area. This is impressively demonstrated by the broad spectrum of the topics of the papers in this vol ume, although they are far from being comprehensive for the work done in the area of distributed systems. Distributed systems are extraordinarily complex and allow many distinct viewpoints. Therefore the literature on distributed systems sometimes may look rather confusing to people not working in the field. Nevertheless there is no reason for resignation: the Summer School was able to show considerable convergence in ideas, approaches and concepts for distributed systems.

The foundations of the chemical dyestuffs industry were laid in 1856 when W. H. Perkin discovered the dye Mauveine. At approximately the same time modern chemistry was establishing itself as a major science. Thus, the chemistry of dyes became that branch of organic chemistry in which the early scientific theories were first used. This early eminence has now been largely lost. In fact, many of our academic and teaching institutions pay little attention to this vitally important branch of organic chemistry. We believe that this book will help to rectify this unfortunate situation. The majority of books that have been published on the subject of dyes have been technologically biased and, in our opinion, do not appeal to the mainstream organic chemist. We have, therefore, aimed at producing a book which emphasises the role of organic chemistry in dyestuffs and we have included appropriate modern theories, especially the modern molecular orbital approaches. We have assumed that the reader possesses a knowledge of the basic principles of organic chemistry;* the only other requirement is a general interest in organic chemistry.** The book should interest the newcomer to chemistry, the established academic, and the dyestuffs chemist himself.