SpringerBriefs in Biochemistry and Molecular Biology – serie
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26 produkter
Gene Therapy for HIV
From Inception to a Possible Cure
Av Gerhard Bauer, Joseph S. Anderson
Häftad, 2014
568 kr
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This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV.Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, …
Secret Lives of Transcription Factors
In Heterochromatin Regulation
Av Willis X. Li, Louise Silver-Morse
Häftad, 2023
568 kr
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This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details …
Lentiviral Vectors and Gene Therapy
Av David Escors, Karine Breckpot m. fl.
Häftad, 2012
568 kr
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Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has …
Phosphorescent Oxygen-Sensitive Probes
Av Dmitri Papkovsky, Alexander V. Zhdanov m. fl.
Häftad, 2012
568 kr
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Biological O2 sensing probes and measurement techniques were first introduced in the late 80s. In the last 3-5 years they have undergone major development that have made them available and affordable for a broad range of applications in various disciplines of the life and biomedical sciences. These …
Fractal Symmetry of Protein Interior
Häftad, 2013
552 kr
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The essential question that fractal dimensions attempt to answer is about the scales in Nature. For a system as non-idealistic and complex as a protein, studying scale-invariance becomes particularly important.Fractal Symmetry of Protein Interior investigates the diverse facets of the various …
Fractal Symmetry of Protein Exterior
Häftad, 2013
552 kr
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The essential question that fractal dimensions attempt to answer is about the scales in Nature. For a system as non-idealistic and complex as a protein, studying scale-invariance becomes particularly important.Fractal Symmetry of Protein Exterior investigates the diverse facets of the various …
Untranslated Gene Regions and Other Non-coding Elements
Regulation of Eukaryotic Gene Expression
Av Lucy W. Barrett, Sue Fletcher m. fl.
Häftad, 2013
552 kr
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There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, …
Gamma-Glutamyl Transpeptidases
Structure and Function
Av Immacolata Castellano, Antonello Merlino
Häftad, 2013
568 kr
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Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short …
Protein Folding
Examining the Challenges from Synthesis to Folded Form
Av Alka Dwevedi
Häftad, 2014
552 kr
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The book will discuss classes of proteins and their folding, as well as the involvement of bioinformatics in solving the protein folding problem. In vivo and in vitro folding mechanisms are examined, as well as the failures of in vitro folding, a mechanism helpful in understanding disease caused by …
Biochemistry of Beer Fermentation
Av Eduardo Pires, Tomáš Brányik
Häftad, 2015
660 kr
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Beer is the most popular alcoholic beverage in the world. Yet, behind each glass of beer there is an enormous amount of work invested. If the first image that comes to your mind is the lifting of heavy bags of malt or carrying kegs, guess again! Most of the work involved in brewing is carried out …
DNA Information: Laws of Perception
Häftad, 2015
568 kr
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This book explores the double coding property of DNA, which is manifested in the digital and analog information types as two interdependent codes. This double coding principle can be applied to all living systems, from the level of the individual cell to entire social systems, seen as systems of …
NF-κB-Related Genetic Diseases
Av Gilles Courtois, Alessandra Pescatore m. fl.
Häftad, 2016
792 kr
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This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, …
Membrane Protein – Lipid Interactions: Physics and Chemistry in the Bilayer
Av Jordi H. Borrell, Òscar Domènech m. fl.
Häftad, 2016
552 kr
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This book has been conceives as a brief introduction to biomembranes physical chemistry for undergraduate students of sciences, and it is particularly dedicated to the lipid-protein membrane interactions. A general introduction is presented in Chapters 1 and 2. The following Chapters, 3 and 4, …
Protein Toxins in Modeling Biochemistry
Häftad, 2016
552 kr
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This succinct volume addresses the production of inactive, potentially toxic proteins in the absence of correct protein folding and the resultant neurodegenerative diseases. Other topics include intrinsic disorder in protein structure and function and the effects of molten globules on protein …
Bacteriophage Applications - Historical Perspective and Future Potential
Av Jessica Nicastro, Shirley Wong m. fl.
Häftad, 2016
624 kr
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This book explores key applications of phage biotechnology and reviews recent advances in phage display technologies. The applications covered were selected on the basis of their significance and representativeness in the field. The small size and enormous diversity of bacteriophages make them …
Structural Bioinformatics Tools for Drug Design
Extraction of Biologically Relevant Information from Structural Databases
Av Jaroslav Koča, Radka Svobodová Vařeková m. fl.
Häftad, 2017
624 kr
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The book describes the individual steps necessary for biomacromolecular fragments analysis, as well as a list of essential software tools. For each step, it also shows corresponding web-based tools in detail and provides practical examples of their use.All tools and databases mentioned in the …
Connexins: The Gap Junction Proteins
Häftad, 2014
552 kr
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Gap-junction proteins, connexins are important cellular entities that regulate various facets of cellular physiology. The connexins constitute large family of proteins. The present book provides basic overview about various aspects of connexin proteins. The book has tried to touch the fundamental …
Biomedical Applications of Natural Proteins
An Emerging Era in Biomedical Sciences
Av Dhiraj Kumar, Rajesh R. Kundapur
Häftad, 2015
568 kr
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This book is intended as a reference guide for graduate students, postgraduate students and researchers with a basic knowledge of protein chemistry who would like to know more about the biomedical applications of natural proteins to promote healthier lives. The book is divided into ten chapters, …
Chaperonopathies
Diseases with Defective Molecular Chaperones
Av Alberto J.L. Macario, Everly Conway de Macario m. fl.
Häftad, 2013
568 kr
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This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of …
Immunity, Tumors and Aging: The Role of HSP70
Häftad, 2013
568 kr
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The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular …
NMR for Chemists and Biologists
Av Rodrigo J Carbajo, Jose L Neira
Häftad, 2013
568 kr
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This book intends to be an easy and concise introduction to the field of nuclear magnetic resonance or NMR, which has revolutionized life sciences in the last twenty years. A significant part of the progress observed in scientific areas like Chemistry, Biology or Medicine can be ascribed to the …
DNA Replication - Damage from Environmental Carcinogens
Häftad, 2015
568 kr
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This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing …
Synthetic Biology
From iGEM to the Artificial Cell
Häftad, 2014
568 kr
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Synthetic Biology (SB) is a revolutionary discipline with a vast range of practical applications, but is SB research really based on engineering principles? Does it contributing to the artificial synthesis of life or does it utilise approaches sufficiently advanced to fall outside the scope of …
Mechanosensory Transduction in Drosophila Melanogaster
Av Xin Liang, Landi Sun m. fl.
Häftad, 2017
568 kr
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This book offers an essential introduction for all graduate students and researchers who are working on or interested in mechanotransduction using fruit flies as their model organisms. Designed for accessibility, it follows a simple five-chapter structure, beginning with a general introduction to …
Mechanotransduction of the Hair Cell
Av Wei Xiong, Zhigang Xu
Häftad, 2018
552 kr
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This book summarizes the emerging experimental evidence on hair-cell mechanotransduction, and covers hair’s cellular structure, biophysical properties, molecular components and functions. Auditory hair cells convert sound-induced vibration into electrical signals. This biological process, …
Modeling Calcium Signaling
A Fractional Perspective
Av Ritu Agarwal, Sunil Dutt Purohit m. fl.
Häftad, 2024
470 kr
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This book focuses on the fundamental processes involved in calcium signaling through fractional mathematical modeling. The intended reader of the book is mathematically proficient students of cell biology, applied mathematics and mathematical biology who are interested in learning about modeling in …
