Raj Kumar – författare

Steroid Hormone Receptors in Endocrine Physiology and Diseases covers the role of steroid hormones in human physiology and receptor activity in the pathophysiology of disease. The book discusses how these receptors can be used as therapeutic targets for the treatment of conditions from cancer to aging, offering immediate applications of biochemical principles into clinical applications such as diagnosis and treatment. This book is a valuable reference for graduate and postdoctoral scientists but is also ideal for medical students interested in the functional role of various steroid hormone receptors in a wide variety of endocrine related diseases.Steroid hormone receptors (SHRs) are known to play vital roles in normal physiology through the control of development, differentiation, metabolic homeostasis and reproduction. Due to their involvement in various pathological and disease conditions, SHRs are also important therapeutic targets in several disorders including inflammation, autoimmune diseases, hormone-dependent cancers, osteoporosis and cardiovascular diseases. Discusses the importance of steroid hormone receptors in the physiology and pathophysiology of various endocrine related diseases Provides state-of-the-art information based on key research findings in the field, along with hypotheses and perspectives for future directions for basic and translational research and clinical applications Offers a comprehensive description of the challenges associated with steroid hormone receptors-based therapies

Bama is a Tamil Dalit feminist writer and novelist. Her autobiographical novel Karukku, which chronicles the joys and sorrows experienced by Dalit Christians in Tamil Nadu, catapulted her to fame. As a prolific writer, she has experimented with all kinds of genres, such as novels, short stories, poems, autobiographical writing, children’s literature, and discursive essays. This book presents a dedicated study of Bama’s work as a writer and activist and situates her in the context of Dalit literature in general and Tamil Dalit literature in particular. It recognises Bama as writer of great relevance especially in bringing to the fore the problematics of Dalit issues and their possible modes of aesthetic articulation through a new Dalit language.Part of the Writer in Context series, this book will be useful for scholars and researchers of Indian literature, Dalit Literature, Dalit Studies, Tamil literature, English literature, comparative literature, postcolonial studies, cultural studies, Green studies. global south studies and translation studies.

The conception of modernity as a radical rupture from the past runs parallel to the conception of Europe as the primary locus of global history. The essays in this volume contest the temporal and spatial divisions—between past and present, modernity and tradition, and Europe’s progress and Asia’s stasis—which the conventional narrative of modernity creates. Drawing on early modern Chinese and Indian history and culture instead, the authors of the book explore the provenance of modernity beyond the west to see it in a transcultural and pluralistic light.The central argument of this volume is that modernity does not have a singular core or essence—a causal centre. Its key features need to be disaggregated and new configurations and combinations imagined. By studying the Bhakti movement, Confucian democracy, and the maritime and agrarian economies of China and India, this book enlarges the terms of debate and revisits devalued terms and concepts like tradition, religion, authority, and rural as resources for modernity. This book will be of great interest to researchers and academicians working in the areas of history, Sociology, Cultural Studies, literature, geopolitics, South Asian and East Asian Studies.

Fused Pyrimidine-Based Drug Discovery covers all categories of fused-pyrimidines along with pharmacological and in silico studies. It covers the chemistry and biological activities, as well as the design of novel fused-pyrimidine scaffolds. N-Heterocyclic scaffolds are found in most known drug candidates, and are of interest to medicinal and organic chemists to design, synthesize and evaluate their biological properties. A variety of fused-pyrimidine molecules have been synthesized and extracted from natural resources, and are found to exhibit various biological activities such as antifolates, anticancer agents, analgesics, antimetabolites, CNS active agents and many more. Some of these scaffolds like purines are also known to have involvement in biological processes and are part of the framework of genetic material. This book focuses on the classification, structural chemistry, and chemical and physical properties along with various approaches for their synthesis. This book is ideal for researchers in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry. Covers US FDA approved fused pyrimidine containing drugs and their analyses Comprises classification based upon fusion of carbocyclic/heterocyclic rings(s) with a pyrimidine ring, and features their synthetic schemes, approaches and strategies Includes new fused-pyrimidine scaffolds, allowing the researcher to predict the mechanisms involved in their synthesis Covers fused pyrimidine containing bioactive compounds from the natural sources Covers in silico studies of known fused pyrimidines and Structure-Activity Relationship (SAR), which will encourage the development of new or modified existing scaffolds with specific biological activities

Lipid Nanoparticles-Based mRNA Delivery System offers a comprehensive exploration of lipid nanoparticles (LNPs), the most promising delivery vehicles for mRNA. The book consolidates current knowledge, identifies research gaps, and provides insights into the latest developments in LNP technologies, making it an essential resource for researchers, pharmaceutical developers, and clinicians at the forefront of mRNA therapeutics. Exploring the intricacies of LNP formulation, the book covers a wide range of topics, including the fundamental principles of lipid nanoparticles, design strategies for effective mRNA encapsulation, and the unique challenges associated with various routes of administration-such as intravenous, oral, transdermal, and intranasal delivery.The book also examines the therapeutic applications of lipid-based systems, particularly in vaccines and cancer immunotherapy, while addressing critical challenges like immunogenicity and regulatory considerations. Final sections provide a forward-looking perspective on future trends and innovations in lipid-based mRNA delivery systems, ensuring that readers are well-equipped to navigate this rapidly evolving field.Provides comprehensive insights into lipid nanoparticle technologies for effective mRNA delivery across various administration routesAddresses real-world challenges and hurdles faced in lipid-based mRNA delivery, including stability, immunogenicity, toxicity, and tissue targetingIncludes in-depth exploration of formulation strategies to optimize mRNA encapsulation and stability in lipid-based systemsExplores forward-looking perspectives on emerging trends and innovations in lipid-based mRNA delivery systems for personalized medicine

Bama is a Tamil Dalit feminist writer and novelist. Her autobiographical novel Karukku, which chronicles the joys and sorrows experienced by Dalit Christians in Tamil Nadu, catapulted her to fame. As a prolific writer, she has experimented with all kinds of genres, such as novels, short stories, poems, autobiographical writing, children’s literature, and discursive essays. This book presents a dedicated study of Bama’s work as a writer and activist and situates her in the context of Dalit literature in general and Tamil Dalit literature in particular. It recognises Bama as writer of great relevance especially in bringing to the fore the problematics of Dalit issues and their possible modes of aesthetic articulation through a new Dalit language.Part of the Writer in Context series, this book will be useful for scholars and researchers of Indian literature, Dalit Literature, Dalit Studies, Tamil literature, English literature, comparative literature, postcolonial studies, cultural studies, Green studies. global south studies and translation studies.

Practical Techniques in Molecular Biotechnology intends to familiarise students with the basics of the well-known experiments of molecular biotechnology and related courses like chemical biotechnology and cell biology. The content of the book will be useful in strengthening the basic skills and help students to apply the concepts to real-world problems. This book emphasises important concepts like bioanalytical techniques, biochemical analysis of proteins, recombinant DNA, and protein technology etc. The text will help students to understand the theoretical aspects of the techniques and provide experience with hands-on techniques to demonstrate practical troubleshooting and data analysis. The text is supported with diagrams, data, summaries for the quick recap and appendices with useful protocols and calculation methods.

The conception of modernity as a radical rupture from the past runs parallel to the conception of Europe as the primary locus of global history. The essays in this volume contest the temporal and spatial divisions—between past and present, modernity and tradition, and Europe’s progress and Asia’s stasis—which the conventional narrative of modernity creates. Drawing on early modern Chinese and Indian history and culture instead, the authors of the book explore the provenance of modernity beyond the west to see it in a transcultural and pluralistic light.The central argument of this volume is that modernity does not have a singular core or essence—a causal centre. Its key features need to be disaggregated and new configurations and combinations imagined. By studying the Bhakti movement, Confucian democracy, and the maritime and agrarian economies of China and India, this book enlarges the terms of debate and revisits devalued terms and concepts like tradition, religion, authority, and rural as resources for modernity. This book will be of great interest to researchers and academicians working in the areas of history, Sociology, Cultural Studies, literature, geopolitics, South Asian and East Asian Studies.

Tourism Marketing: A Strategic Approach presents a variety of practical application tools, skills, practices, models, approaches, and strategies that are proving themselves effective in tourism marketing. The volume considers overall infrastructure, socioeconomic conditions, and modern tourism business infrastructure in discussing the efficiency of good strategies and practices and their impact on business and economic growth. Tourism is one of the fastest growing industries, and in the next few decades, it will play a role in many fields, such human resources, national economic growth, and more.

Tourism Marketing: A Strategic Approach presents a variety of practical application tools, skills, practices, models, approaches, and strategies that are proving themselves effective in tourism marketing. The volume considers overall infrastructure, socioeconomic conditions, and modern tourism business infrastructure in discussing the efficiency of good strategies and practices and their impact on business and economic growth. Tourism is one of the fastest growing industries, and in the next few decades, it will play a role in many fields, such human resources, national economic growth, and more.

Major-General Farhan Al-Balawi is a loyal soldier in the Saudi Arabian army who dotes on his beloved daughter, Maryam, his pride in her learning and independent spirit sharpened by the death of his elder son and his estrangement from the younger who has opted to pursue a hedonistic western lifestyle in the USA. Despite the love she shares with her family, her respect for her father, the pride she takes in her Arabian heritage and her loyalty to Islam, Maryam yearns for travel and the opportunity to continue her education in a European university. But then Farhan announces that Maryam is to marry - the fulfilment of a solemn promise made before Maryam was born and to a man who once saved Farhan's life - that Farhan's daughter would one day marry his old army comrade's son. Maryam endeavours to stifle her bitter disappointment, and to honour her father's wishes she complies with the betrothal. Then she meets Joe, an American dentist- and a Jew. As Joe and Maryam pursue an increasingly intimate clandestine relationship they dare to dream of freedom and of a life together.But Joe is gradually drawing the attention of the Muttawa, the feared religious police, and when Maryam realises that she is pregnant it is then that her trials really begin.

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity.The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.    ​

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity.The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.    ​

This succinct volume addresses the production of inactive, potentially toxic proteins in the absence of correct protein folding and the resultant neurodegenerative diseases. Other topics include intrinsic disorder in protein structure and function and the effects of molten globules on protein toxicity. This concise and yet thorough text also discusses using toxin structure as a model for studying structural and functional aspects of protein chemistry. Protein Toxins in Modeling Biochemistry, a SpringerBrief, is essential reading for advanced researchers, scientists and advanced graduate students interested in protein chemistry and related areas of biochemistry and molecular science.