Circadian Rhythms and Biological Clocks Part B

Dr. Sehgal is the John Herr Musser Professor of Neuroscience and Director of a Program in Chronobiology at the Perelman School of Medicine, University of Pennsylvania. She has also been an Investigator of the Howard Hughes Medical Institute since 1997. Dr. Sehgal received her Ph.D. from the Graduate School of Medical Sciences, Cornell University, working with Dr. Moses Chao, and conducted her postdoctoral work with Dr. Michael Young at Rockefeller University. A major focus in her laboratory is the cellular and molecular basis of circadian rhythms, using the fruit fly, Drosophila melanogaster as a model system. Her laboratory also developed a Drosophila model for the study of sleep, which has been adopted by laboratories worldwide, and is rapidly provding insight into the regulation and function of sleep. In 2009, Dr. Sehgal was elected to the Institute of Medicine and in 2011 to the American Academy of Arts and Sciences.

"…these volumes provide a remarkable summary of the methods, experimental systems, and findings of cutting-edge research into circadian rhythms….an essential resource for all types of scientists studying chronobiology, as well as an informative read for anyone who wishes to understand better the ticking of their biological clock." --The Quarterly Review of BiologyPraise for the Series: "Should be on the shelves of all libraries in the world as a whole collection." --Chemistry in Industry "The work most often consulted in the lab." --Enzymologia"The Methods in Enzymology series represents the gold-standard." --Neuroscience

• 1. Measuring Synchrony in the Mammalian Central Circadian CircuitErik D. Herzog, István Z. Kiss and Cristina Mazuski2. Patch Clamp Electrophysiology in Drosophila Circadian Pacemaker NeuronsMatthieu Flourakis and Ravi Allada3. Glial Cell Regulation of Rhythmic BehaviorF. Rob Jackson, Fanny S. Ng, Sukanya Sengupta, Samantha You and Yanmei Huang4. Neurophysiological Analysis of the Suprachiasmatic Nucleus; A Challenge at Multiple LevelsJohanna H. Meijer and Stephan Michel5. Photic Entrainment in Drosophila Assessed by Locomotor Activity RecordingsMatthias Schlichting and Charlotte Helfrich-Förster6. Photic Regulation of Clock SystemsSteven Hughes, Aarti Jagannath, Mark W. Hankins, Russell G. Foster and Stuart N. Peirson7. Response of Peripheral Rhythms to the Timing of Food IntakeMegumi Hatori and Satchidananda Panda8. Circadian Regulation of Cellular PhysiologyPeek, C.B., Ramsey, K.M. , Levine, D.C. , Marcheva, B., Perelis, M and  Bass, J.9. Analysis of the Redox Oscillations in The Circadian ClockworkNikolay B. Milev, Guillaume Rey, Utham K. Valekunja, Rachel S. Edgar, John S. O’Neill and Akhilesh B. Reddy10. Clocks and Cardiovascular FunctionSarah C. McLoughlin, Philip Haines and Garret A. FitzGerald11. Measuring Circadian Clock Function in Human CellsLudmila Gaspar and Steven A. Brown12. Human Activity and Rest in SituTill Roenneberg , Lena K Keller , Dorothee Fischer, Joana L Matera, Céline Vetter, and Eva C Winnebeck13. Phenotyping of Neurobehavioral Vulnerability to Circadian Phase During Sleep LossNamni Goel, Mathias Basner and David F. Dinges14. Genetics of Human Sleep Behavioral PhenotypesPei-Ken Hsu , Louis J. Ptáček and Ying-Hui Fu15. Sleep and Circadian Rhythm Disruption and Recognition Memory in SchizophreniaShu K. E. Tam, David Pritchett, Laurence A. Brown, Russell G. Foster, David M. Bannerman and Stuart N. Peirson