The Molecular Nutrition of Fats

Häftad, Engelska, 2018

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Beskrivning

The Molecular Nutrition of Fats presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell, and their role in health and disease. Subject areas include molecular mechanisms, membranes, polymorphisms, SNPs, genomic wide analysis, genotypes, gene expression, genetic modifications and other aspects. The book is divided into three sections, providing information on the general and introductory aspects, the molecular biology of the cell, and the genetic machinery and its function. Topics discussed include lipid-related molecules, dietary lipids and lipid metabolism, high fat diets, choline, cholesterol, membranes, trans-and saturated fatty acids, and lipid rafts.

Other sections provide comprehensive discussions on G protein-coupled receptors, micro RNA, transcriptomics, transcriptional factors, cholesterol, triacylglycerols, beta-oxidation, cholesteryl ester transfer, beta-oxidation, lysosomes, lipid droplets, insulin mTOR signaling and ligands, and more.

Summarizes molecular nutrition in health as related to fats
Discusses the impact of fats on cancer, heart disease, dementia, and respiratory and intestinal disease
Includes preclinical, clinical and population studies
Covers the genome, the whole body and whole communities
Includes key facts, a mini dictionary of terms and summary points

Produktinformation

Utgivningsdatum:2018-11-01
Mått:216 x 276 x undefined mm
Vikt:1 270 g
Format:Häftad
Språk:Engelska
Antal sidor:470
Förlag:Elsevier Science
ISBN:9780128112977

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Mer om författaren

Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications.

Innehållsförteckning

Section 1: General and Introductory Aspects1. Intestinal health and bioactive lipids2. C-reactive protein and plasma fatty acids: public health concerns and implications3. The role of a fatty acid chain elongase, Elovl,1 in zebrafish and implications fcor human kidney4. Dietary lipids and lipid metabolism: An overview5. Fatty acids use in neurological disease6. The Neurocan-cartilage intermediate layer protein NCAN-CILP2 region and plasma lipid levels7. Role of cholesterol on controlling membrane phospholipid asymmetry8. Adipose tissue and peritoneal dialysis9. Lipid biomarkers and cancer10. Absorption of dietary fat and their metabolism in enterocytes11. The lipid-lowering action of iodothyronines12. Dietary Omega-3s and Muscle Composition in adults13. An overview of cholesterol absorption14. Triacylglycerols and use of docosahexaenoic acid at the sn-2 position15. Safety of Docosahexaenoic acid (DHA) ethyl ester and implications for human studies16. Fish oil supplementation and depression17. Drugs to counter SFA-mediated lipointoxication18. Lipoprotein (a) [Lp(a)]19. Endoplasmic reticulum (ER) stress, and white adipose tissue lipolysis20. Trans-fat intake and behaviour21. Glycemic index meal feeding and lipid profiling22. Beef Fat23. Lipid pathway in liver cells and its modulation by dietary extractsSection 2: Molecular Biology of the Cell24. Subcellular organelles: lipid droplets25. Optimized omega-3 EPA:DHA 6:1 and pulmonary arterial hypertension26. Omega-3 fatty acids and epilepsy27. Docosahexaenoic acid (DHA): A dietary supplement with promising anticancer potential28. Periaortic adipose tissue in obesogenic diets29. Genomics, statins and lipid metabolism30. Cholesterol metabolism in atherosclerosis development31. Lipid metabolism in dyslipidemia and familial hypercholesterolemia32. Lipid Profile of Progenitor Cells33. Trans-fatty acids and mortality34. Saturated and monounsaturated fatty acids associate with development and prematurity35. Hedgehog signaling and liver lipid metabolism36. Cyclosporin A-Induced Dyslipidemia and LDL Receptors37. Hypoxia and adipose tissue lipid breakdown38. Intramyocellular fat storageSection 3: Genetic Machinery and Its Function39. Fatty acid binding protein 2 genes and public health implications for diabetes40. Transcriptional factor modulation by lipid peroxidation-derived aldehydes41. Heterogeneity of white adipose tissue42. Nomenclature, classes and functions of lipids and lipid-related molecules, Dietary lipids43. Lipid metabolism: an overview - The mitochondria as a site of fatty acid beta-oxidation44. Fatty acids, gut bacteria and immune cell function