The Common Marmoset in Captivity and Biomedical Research

Robert P. Marini, DVM, DACLAM, Assistant Director, is a member of MIT’s Division of Comparative Medicine’s clinical staff and is Chief of the Division’s clinical surgical facilities. Dr. Marini is responsible for coordinating and supervising all major survival surgery in non-rodent mammalian species. Harvard Medical School, Boston MA USA Suzette D. Tardif, Ph.D., is the Associate Director of Research at the Southwest National Primate Research Center. She is an adjunct faculty of The Barshop Institute. The Tardif laboratory's activities center on the development of the marmoset monkey as a disease model. Dr. Tardiff is a past-President of the American Society of Primatologists. Keith Mansfield is Associate Director for Resource and Collaborative Affairs and Chair, Division of Primate Resources, New England National Primate Research Center, Harvard Medical School, Harvard University, Southborough, US. His research focuses on primarily on the recognition of spontaneously occurring infectious diseases of nonhuman primates and their development into novel animal models to investigate disease pathogenesis. Prof. James G. Fox obtained his Doctor of Veterinary Medicine at Colorado State University, Fort Collins, and, as an NIH postdoctoral fellow, received a Master of Science in Medical Microbiology at Stanford University. Dr. Fox is an adjunct professor at Tufts University School of Veterinary Medicine. He is a diplomate and a past president of the American College of Laboratory Animal Medicine, as well as a past president of the Massachusetts Society for Medical Research and the American Association of Veterinary Medical Colleges. Additionally, he has served as past chairman of the AAALAC Council and the NCCR/NIH Comparative Medicine Study Section. He is also an elected fellow of the Infectious Disease Society of America and the American Gastroenterological Association. He was recruited to MIT and created the Division of Comparative Medicine, which he directed from 1974 until 2021. As a faculty member in the MIT Department of Biological Engineering, Professor Fox received numerous scientific awards and was elected to the National Academy of Medicine in 2004. Dr. Fox has been the principal investigator of an NIH postdoctoral training grant for veterinarians for 30 years and has trained 90 veterinarians for careers in biomedical research. The NIH has continuously funded him to study infectious diseases of the gastrointestinal tract, where he has studied the gastrointestinal microbiome and how it interfaces with and influences the host’s immune response to gastrointestinal pathogens, particularly oncogenic Helicobacter species. He has authored over 600 papers, 84 chapters, holds 4 patents and has authored or edited 18 comparative medicine texts.

"This book is the result of an international effort, and it provides an in-depth review of the common marmoset including numerous excellent illustrations, particularly in the anatomy and neuroanatomy sections. ...This book will be an invaluable reference for colony managers, veterinarians, behaviorists, and investigators involved in the care, propagation, and research application of common marmosets. Moreover, the value of this book extends beyond the biomedical research community because its contents cover the broad topic of the natural history of common marmosets, which will be of interest to the zoological and conservation communities as well." --Journal of the American Veterinary Medical Association

• Section I: BIOLOGY AND MANAGEMENT1. Taxonomy and Natural History2. The Anatomy of the Common Marmoset3. Neuroanatomy of the Marmoset4. Marmoset Nutrition and Dietary Husbandry5. Husbandry and Housing of Common Marmosets6. Normal Clinical and Biological Parameters of the Common Marmoset (Callithrix jacchus)7. Behavior and Behavioral Management8. Reproduction, Growth, and Development9. Regulatory ConsiderationsSection II: DISEASES AND CLINICAL APPLICATIONS10. Physical Examination, Diagnosis, and Common Clinical Procedures11. Anesthesia and Common Surgical Procedures12. Diseases of the Urogenital System13. Diseases of the Gastrointestinal System14. Bone, Muscle, and Skeletal Disease15. Viral Diseases of Common Marmosets16. Bacterial Diseases17. Parasitic Diseases18. Neoplastic DiseasesSection III: RESEARCH AND APPLICATIONS19. The Genome of the Common Marmoset20. Creating Genetically Modified Marmosets21. Marmosets in Aging Research22. The Marmoset Monkey as a Model for Visual Neuroscience23. Marmosets in Neurologic Disease Research: Parkinson’s Disease24. Experimental Autoimmune Encephalomyelitis in the Marmoset as a Translational Model for Multiple Sclerosis25. Marmosets in Auditory Research26. The Marmoset as a Model in Behavioral Neuroscience and Psychiatric Research27. The Use of the Marmoset in Toxicity Testing and Nonclinical Safety Assessment Studies28. Experimental Infections of the Common Marmoset (Callithrix jacchus)29. Insights Gained from Marmoset Endocrine Research