Inbunden, Engelska, 2020

Second Generation Cell and Gene-Based Therapies

Biological Advances, Clinical Outcomes and Strategies for Capitalisation

Av Alain Vertes, Nathan J. Dowden, Devyn Smith, Nasib Qureshi

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Beskrivning

Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products.The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals.

Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization
"Perspectives" section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights
Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies

Produktinformation

Utgivningsdatum: 2020-02-10
Mått: 191 x 235 x 47 mm
Vikt: 1 860 g
Format: Inbunden
Språk: Engelska
Antal sidor: 846
Förlag: Elsevier Science
ISBN: 9780128120347

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Mer om författaren

University of Illinois at Urbana-Champaign, Institut Pasteur Paris, and University of Lille Flanders-Artois• Sloan Fellow from London Business School and a microbiologist by training (University of Illinois at Urbana-Champaign, Institut Pasteur Paris, and University of Lille Flandres-Artois). • Consulting, Partnering & Fund Raising, Founder, Managing Director, NxR Biotechnologies, Switzerland.• Dr. Vertès is a strategy and business development consultant for cell therapeutic biotech companies, and works to enable seed funding in the field. Focusing on technology deployment and innovation commercialization, he has contributed to both industrial and pharmaceutical biotechnology, in different functions including research, manufacturing, contract research, and strategic alliances in pharmaceuticals (Lilly, Pfizer, Roche). • Championed radical innovation for bringing to patients disease-modifying, paradigm-changing therapeutics such as siRNA, and led in a scientific and business manner Roche’s global cell therapeutics strategy and implementation team resulting in Roche’s entry in 2010 in the field of regenerative medicine.• Member, Industry Committee-Europe, Tissue Engineering and Regenerative Medicine International Society• Co-Editor, Stem Cells in Regenerative Medicine: Science, Regulation and Business Strategies (Wiley, 2015). • Head of Operations & Strategy, Medicinal Sciences Division of R&D, Pfizer Inc.• Responsible for all cell & gene therapy products, as well as previously developing Pfizer’s Regenerative Medicine program.• PhD in Genetics from Harvard Medical School.• Adjunct faculty member at Northeastern University. Research Chemical/Biochemical Engineer, United States Department of Agriculture (USDA), Agricultural Research Service (ARS), National Center for Agricultural Utilization Research (NCAUR), Peoria, IL, USA.PhD (Chemical/Biological Engineering), PhD (Fermentation Technology)Fellow in American Institute of Chemical Engineers (AIChE), Society for Industrial Microbiology & Biotechnology (SIMB), and American Institute of Chemists (AIC).Co-Editor, Stem cells in Regenerative Medicine (Wiley, 2015)

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